WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy

Fu, Kang; Jing, Chenyang; Shi, Jinsong; Mao, Shuya; Lu, Rui; Yang, Miao; Chen, Yang; Qian, Bin; Wang, Yu; Li, Limin

doi:10.1016/j.bbrc.2024.150524

Biochemical and Biophysical Research Communications

2024

DOI: 10.1016/j.bbrc.2024.150524

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WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy

Kang Fu,

Chenyang Jing,

Jinsong Shi

et al.

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Cited by 2 publications

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Post‐Translational Modifications of RNA‐Modifying Proteins in Cellular Dynamics and Disease Progression

Lin,

et al. 2024

Advanced Science

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RNA‐modifying proteins, classified as “writers,” “erasers,” and “readers,” dynamically modulate RNA by adding, removing, or interpreting chemical groups, thereby influencing RNA stability, functionality, and interactions. To date, over 170 distinct RNA chemical modifications and more than 100 RNA‐modifying enzymes have been identified, with ongoing research expanding these numbers. Although significant progress has been made in understanding RNA modification, the regulatory mechanisms that govern RNA‐modifying proteins themselves remain insufficiently explored. Post‐translational modifications (PTMs) such as phosphorylation, ubiquitination, and acetylation are crucial in modulating the function and behavior of these proteins. However, the full extent of PTM influence on RNA‐modifying proteins and their role in disease development remains to be fully elucidated. This review addresses these gaps by offering a comprehensive analysis of the roles PTMs play in regulating RNA‐modifying proteins. Mechanistic insights are provided into how these modifications alter biological processes, contribute to cellular function, and drive disease progression. In addition, the current research landscape is examined, highlighting the therapeutic potential of targeting PTMs on RNA‐modifying proteins for precision medicine. By advancing understanding of these regulatory networks, this review seeks to facilitate the development of more effective therapeutic strategies and inspire future research in the critical area of PTMs in RNA‐modifying proteins.

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Post‐Translational Modifications of RNA‐Modifying Proteins in Cellular Dynamics and Disease Progression

Lin,

et al. 2024

Advanced Science

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miR-151a-5p predicts severity of diabetic retinopathy and protects from retinal cell injury by inactivating MAPK signaling via DKK3

Yu,

Zhang,

Zhou

et al. 2024

Experimental Eye Research

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WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy

Cited by 2 publications

References 44 publications

Post‐Translational Modifications of RNA‐Modifying Proteins in Cellular Dynamics and Disease Progression

Post‐Translational Modifications of RNA‐Modifying Proteins in Cellular Dynamics and Disease Progression

miR-151a-5p predicts severity of diabetic retinopathy and protects from retinal cell injury by inactivating MAPK signaling via DKK3

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