Wuchereria bancrofti filariasis in French Polynesia: Age-specific patterns of microfilaremia, circulating antigen, and specific IgG and IgG4 responses according to transmission level

Chanteau, Suzanne; Glaziou, Philippe; Plichart, Catherine; Luquiaud, Patrick; Moulia-Pelat, J. P.; Nguyen, Lam; Cartel, J.-L.

doi:10.1016/0020-7519(94)00088-6

Cited by 29 publications

(22 citation statements)

References 9 publications

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“…20 As seen in other endemic communities, [27][28][29] overall and agespecific prevalences of CFA were considerably higher than those of mf, implying that many more individuals were actually infected than those in whom mf were detected. This was more pronounced in the low than in the high endemicity community, and it was more pronounced in children than in adults (especially in the low endemicity community).…”

Section: Discussionmentioning

confidence: 79%

Bancroftian filariasis infection, disease, and specific antibody response patterns in a high and a low endemicity community in East Africa.

Simonsen

Meyrowitsch²,

Jaoko³

et al. 2002

Am J Trop Med Hyg

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Abstract. Bancroftian filariasis infection, disease and specific antibody response patterns in a high and a low endemicity community in East Africa were analyzed and compared to assess the relationship between these parameters and community transmission intensity. Overall prevalences of microfilaremia and circulating filarial antigenemia were 24.9% and 52.2% in the high and 2.7% and 16.5% in the low endemicity community, respectively. A positive history of acute attacks of adenolymphangitis was given by 12.2% and 7.1% of the populations, 4.0% and 0.9% of the adult (Ն 20 years old) individuals presented with limb lymphedema, and 25.3% and 5.3% of the adult males had hydrocele, in the high and the low endemicity community, respectively. Both infection and disease appeared earlier and reached much higher levels in the high than in the low endemicity community. The observed overall and age-specific infection and disease patterns in the two communities were in agreement with the view that these are primarily shaped by transmission intensity. No statistically significant relationships between infection status of fathers and mothers and that of their children were observed in any of the communities for either microfilaremia or for circulating filarial antigenemia. The overall levels (prevalence and geometric mean intensity) of filarial-specific IgG1, IgG2, IgG4, and IgE were significantly higher in the high endemicity community than in the low endemicity community. Surprisingly, the opposite pattern was found for IgG3. Community transmission intensity thus appears to be an important determinant of observed inter-community variation in infection, disease, and host response patterns in Bancroftian filariasis.

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Section: Discussionmentioning

confidence: 79%

Bancroftian filariasis infection, disease, and specific antibody response patterns in a high and a low endemicity community in East Africa.

Simonsen

Meyrowitsch²,

Jaoko³

et al. 2002

Am J Trop Med Hyg

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“…The dynamics of the development of a W. bancrofti microfilaraemia in humans are not well understood but are probably related to the intensity and duration of exposure (Chanteau et al, 1995). The results of a longitudinal study in a cohort of children in Haiti indicated that, although filarial infections are acquired early in life, the initial intensity of infection is low and requires some time to build up to detectable levels .…”

Section: Discussionmentioning

confidence: 98%

“…In the present study, the female subjects of reproductive age had slightly lower prevalences and intensities of microfilaraemia and antigenaemia than their agematched male counterparts, although the differences were not statistically significant. In areas where W. bancrofti is transmitted by day-biting mosquitoes, such as Aedes species, it is the male workers engaged in outdoor activities who are probably most likely to be bitten by infected vectors (Chanteau et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Immuno–parasitological assessment of bancroftian filariasis in a highly endemic area along the River Sabaki, in Malindi district, Kenya

Njenga

Wamae

Mwandawiro

et al. 2007

Annals of Tropical Medicine & Parasitology

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Lymphatic filariasis is endemic in the coastal areas of Kenya, with four major foci identified in the early 1970s. The prevalence and intensity of Wuchereria bancrofti infection, together with antifilarial antibody responses, were assessed in a historically highly endemic focus along the River Sabaki, in Malindi district. The prevalences of microfilaraemia and antigenaemia (detected by Og4C3 ELISA) were >20% and >40%, respectively, and both increased steadily with age. The high prevalences of antifilarial IgG1 (86%) and IgG4 (91%) responses indicate that most people living in this setting are exposed to W. bancrofti infection. The children investigated had higher levels of antifilarial IgG1 than the adults. The results of this study, based on a battery of currently available parasitological and immunological methods, provide an epidemiological update on lymphatic filariasis on the northern Kenyan coast. They show that the River Sabaki area is still an important focus for bancroftian filariasis and highlight the importance of implementing an elimination programme, to interrupt the transmission of W. bancrofti in all areas of endemicity in Kenya. The detailed baseline data collected in the River Sabaki area make the communities studied ideal as sentinel sites for epidemiological monitoring and the evaluation of the impact of mass drug administrations to eliminate lymphatic filariasis.

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“…The differences observed between the genders in the present investigation have been demonstrated in other studies of bancroftian filariasis as well, primarily during the postpubertal reproductive years. 2,36,37 Studies have demonstrated not only a greater prevalence of Mf 2,3,38-43 and disease 42,44 in male subjects, but also higher antigen 39 and antibody 37,39 levels. Except for children, males in the current study also tended toward not only a higher prevalence of both Mf and CAg but also higher levels of Mf, CAg, and IgG4.…”

Section: Discussionmentioning

confidence: 99%

Worm burden and host responsiveness in Wuchereria bancrofti infection: use of antigen detection to refine earlier assessments from the South Pacific.

Steel¹,

Ottesen²,

Weller³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. A population from the Wuchereria bancrofti-endemic island of Mauke was reevaluated retrospectively by use of the Og4C3 circulating antigen (CAg) enzyme-linked immunosorbent assay to assess active infection in relation to host responses by age and gender. Use of microfilaremia (Mf) alone misclassified ϳ 50% of infected people, although CAg and Mf levels were positively correlated. Levels of CAg peaked between those aged 31-60 years; men aged Ͼ 60 years had a significantly higher CAg prevalence (Ͼ 90%) than women. Filaria-specific immunoglobulin (Ig) G4 reached maximum levels in both genders at age 51-60 years. By analysis of variance, both age and gender significantly influenced CAg and IgG4, with men having higher levels of both in the total population. Individuals positive for CAg had significantly lower lymphocyte proliferation responses to parasite antigen than did CAg-negative people, regardless of clinical status. This study reemphasizes the importance of CAg measurements for accurately assessing filarial prevalence and clinical status and demonstrates the relationship between active infection and immune responsiveness.

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Wuchereria bancrofti filariasis in French Polynesia: Age-specific patterns of microfilaremia, circulating antigen, and specific IgG and IgG4 responses according to transmission level

Cited by 29 publications

References 9 publications

Bancroftian filariasis infection, disease, and specific antibody response patterns in a high and a low endemicity community in East Africa.

Bancroftian filariasis infection, disease, and specific antibody response patterns in a high and a low endemicity community in East Africa.

Immuno–parasitological assessment of bancroftian filariasis in a highly endemic area along the River Sabaki, in Malindi district, Kenya

Worm burden and host responsiveness in Wuchereria bancrofti infection: use of antigen detection to refine earlier assessments from the South Pacific.

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