Wydzielanie serotoniny i melatoniny u kobiet po menopauzie z zaburzeniami odżywiania

Chojnacki, Cezary; Walecka-Kapica, Ewa; Błońska, Aleksandra; Winczyk, Katarzyna; Stępień, Agnieszka; Chojnacki, Jan

doi:10.5603/ep.2016.0012

Cited by 14 publications

(14 citation statements)

References 31 publications

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“…However, only a few studies have analyzed the relationship between serotonin and melatonin levels and the correlation with the blood serum. Modai et al [61] analyzed 10 healthy men, and Chojnacki et al [62] presented serotonin and melatonin secretion in postmenopausal women with eating disorders. To the best of our knowledge, only Rao et al [63] and Bozhko et al [64] provided an analysis of depressed patients after they had received light therapy.…”

Section: Circadian Rhythm and Melatonin In Depressionmentioning

confidence: 99%

Pathophysiology of Depression: Molecular Regulation of Melatonin Homeostasis – Current Status

Dmitrzak‐Węglarz

Reszka

2017

Neuropsychobiology

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Circadian rhythm alterations resulting in disturbed sleep and disturbed melatonin secretion are flagship features of depression. Melatonin, known as a hormone of darkness, is secreted by the pineal gland located near to the center of the brain between the two hemispheres. Melatonin has an antidepressant effect by maintaining the body’s circadian rhythm, by regulating the pattern of expression of the clock genes in the suprachiasmatic nucleus (SCN) and modifying the key genes of serotoninergic neurotransmission that are linked with a depressive mood. Melatonin is produced via the metabolism of serotonin in two steps which are catalyzed by serotonin N-acetyltransferase (SNAT) and acetylserotonin-O-methyltransferase (ASMT). Serotonin, SNAT, and ASMT are key melatonin level regulation factors. Melatonin acts mainly on the MT₁ and MT₂ receptors, which are present in the SCN, to regulate physiological and neuroendocrine functions including circadian entrainment, referred to as a chronobiotic effect. Although melatonin has been known about and refereed to for almost 50 years, the relationship between melatonin and depression is still not clear. In this review, we summarize current knowledge about the genetic and epigenetic regulation of enzymes involved in melatonin synthesis and metabolism as potential features of depression pathophysiology and treatment. Confirmation that melatonin metabolism in peripheral blood partially reflects a disorder in the brain could be a breakthrough in the standardization of measurements of melatonin level for the development of treatment standards, finding new therapeutic targets, and elaborating simple noninvasive clinical tests.

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Section: Circadian Rhythm and Melatonin In Depressionmentioning

confidence: 99%

Pathophysiology of Depression: Molecular Regulation of Melatonin Homeostasis – Current Status

Dmitrzak‐Węglarz

Reszka

2017

Neuropsychobiology

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“…The reasons for these remains unclear but likely multifactorial. There are several prior findings probably relevant and worth discussing [34,35,36]. Melatonin, a hormone secreted by the pineal gland, has been found to be relevant to female hormone and obesity [34,35].…”

Section: Discussionmentioning

confidence: 99%

“…There are several prior findings probably relevant and worth discussing [34,35,36]. Melatonin, a hormone secreted by the pineal gland, has been found to be relevant to female hormone and obesity [34,35]. Prior study reported that alterations in the metabolism or a disturbed circadian pattern of melatonin may play a role in the development of delirium [36].…”

Section: Discussionmentioning

confidence: 99%

Incidence and Risk Factors of Postoperative Delirium Following Primary Elective Total Hip Arthroplasty: A Retrospective Nationwide Inpatient Sample Database Study

Yang¹,

Wang²,

Huang³

et al. 2020

Preprint

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Abstract Background: Postoperative delirium is a common complication following major surgeries, leading to a variety of adverse effects. However, there is a paucity of literatures studying the incidence and risk factors of delirium after primary elective total hip arthroplasty (THA) using a large-scale national database. Methods: A retrospective database analysis was performed based on Nationwide Inpatient Sample (NIS) from 2009-2014. Patients who underwent primary elective THA were included. Patient demographics, comorbidities, length of hospital stay (LOS), total charges, in-hospital mortality, and major and minor perioperative complications were evaluated. Results: A total of 388,424 primary elective THAs were obtained from the NIS database, and the general incidence of delirium after THA was 0.90%. Patients with delirium after THA presented more comorbidities, increased LOS, extra hospital charges, and higher in-hospital mortality rate (P<0.001). Delirium following THA was associated with major complications during hospitalization including acute renal failure and pneumonia. Risk factors of postoperative delirium included advanced age, alcohol or drug abuse, depression, neurological disorders, psychoses, fluid and electrolyte disorders, diabetes, weight loss, deficiency anemia, coagulopathy, hypertension, congestive heart failure, valvular disease, pulmonary circulation disorders, peripheral vascular disorders, and renal failure. Both female and obesity were detected to be protective factors. Conclusions: The results of our study identified a relatively low incidence of delirium after primary elective THA. Postoperative delirium of THA was associated with increased comorbidities, LOS, total charges, in-hospital mortality, and major perioperative complications including acute renal failure and pneumonia. It is of benefit to study risk factors of postoperative delirium to moderate its consequences.

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“…Un creciente cuerpo de evidencia apoya el rol de las hormonas reproductivas, específicamente el estrógeno, para el riesgo de TCA y síntomas relacionados. Al igual que la pubertad, la peri-menopausia se caracteriza por cambios estrogénicos que conllevan una vulnerabilidad para el desarrollo o reaparición del TCA 3,32 .…”

Section: Etiopatogenia/comorbilidadunclassified

“…caquexia, neumonía o insuficiencia cardíaca). Aproximadamente, 42% se benefició del tratamiento, siendo el enfoque más exitoso la terapia combinada (psicoterapia cognitivo-conductual y medicamentos) 50 y eventualmente de remplazo hormonal en mujeres posmenopáusicas 32 . Forman y Davis 51 observaron que al ingreso hospitalario por un TCA, las pacientes de mediana edad experimentaron un mayor cambio positivo con respecto a la depresión y a la insatisfacción con la imagen corporal y describieron la terapia familiar y grupal focalizada en la pérdida y el dolor como significativamente más útiles que en las pacientes adultas jóvenes.…”

Section: Tratamientounclassified

Trastornos alimentarios en mujeres adultas (maduras)

Behar¹

2018

Rev. chil. neuro-psiquiatr.

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Background: There is evidence of an increasing number of middle-aged women suffering from eating disorders (ED). Objective: To describe women in adulthood with eating disorders, in relation to their epidemiological, aetiopathogenic, clinical, evolutionary and therapeutic characteristics. Method: A comprehensive literature search was carried out using the electronic databases MEDLINE/PubMed, SciELO and the Cochrane Library, as well as specialized consultation texts, from 1984 to present (2017). Results: Clinical characteristics and most of the risk factors (biological, psychological, sociocultural) are similar to those found in younger women, and may be more likely the continuation of a previous ED or a late onset of the pathology. The most distinctive and relevant variables for middle-aged women are menopause and anxiety related to aging, who seem to be less likely to develop anorexia nervosa and bulimia nervosa, but rather binge eating disorder and other unspecified and specified threshold EDs. Depression and systemic physical comorbidities are very common. The therapeutic management is multidisciplinary and the lack of adherence implies a chronic outcome. Conclusions: Physicians should bear in mind the increased risk of EDs in peri-menopausal women, when changes in physical appearance can be drastic, unexpected and undesirable, and should strive to explore this possibility in their daily clinical practise.

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Wydzielanie serotoniny i melatoniny u kobiet po menopauzie z zaburzeniami odżywiania

Cited by 14 publications

References 31 publications

Pathophysiology of Depression: Molecular Regulation of Melatonin Homeostasis – Current Status

Pathophysiology of Depression: Molecular Regulation of Melatonin Homeostasis – Current Status

Incidence and Risk Factors of Postoperative Delirium Following Primary Elective Total Hip Arthroplasty: A Retrospective Nationwide Inpatient Sample Database Study

Trastornos alimentarios en mujeres adultas (maduras)

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