Wytyczne EAACI/GA2LEN/EDF/WAO dotyczące definicji, klasyfikacji, diagnostyki i leczenia pokrzywki

Zuberbier, T.; Aberer, W.; Asero, R.; Latiff, A.; Baker, D.; Ballmer-Weber, B.; Bernstein, J.; Bindslev‐Jensen, Carsten; Brzoza, Z.; Bedrikow, R.; Canonica, G.; Church, M.; Craig, T.; Danilycheva, I.; Dressler, C.; Ensina, L.; Giménez-Arnau, A.; Godse, K.; Gonçalo, M.; Grattan, C.; Hebert, J.; Hide, M.; Kaplan, A.; Kapp, A.; Katelaris, C.; Kocatürk, Emek; Kulthanan, K.; Larenas-Linnemann, D.; Leslie, T.; Magerl, M.; Mathelier-Fusade, P.; Meshkova, R.; Metz, Martin; Nast, A.; Nettis, E.; Oude-Elberink, H.; Rosumeck, S.; Saini, S.; Sánchez-Borges, M.; Schmid‐Grendelmeier, Peter; Staubach, P.; Sussman, G.; Toubi, E.; Vena, G.; Vestergaard, Christian; Wedi, B.; Werner, R.; Zhao, Zhiwei; Maurer, Martin

doi:10.5114/pja.2020.93827

Cited by 3 publications

(1 citation statement)

References 143 publications

(164 reference statements)

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“…The Urticaria Activity Score (UAS) was used for the assessment of disease activity in patients with CSU. This questionnaire analyses the number of wheals and the intensity of pruritus in a recommended 7-day monitoring period (UAS7), with once-daily documentation (resulting in a summary score from 0 to 42 points) [ 36 ]. Additionally, intensity of itch was evaluated with the Visual Analogue Scale (VAS) as an average pruritus from the previous week.…”

Section: Methodsmentioning

confidence: 99%

Serum Levels of Vascular Endothelial Growth Factor, Platelet Activating Factor and Eosinophil-Derived Neurotoxin in Chronic Spontaneous Urticaria—A Pilot Study in Adult Patients

Gomułka

Medrala

2022

IJMS

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Chronic spontaneous urticaria (CSU) is a skin disease characterized by the presence of wheals, angioedema, or both for at least 6 weeks. Although, CSU is often regarded as autoimmune in nature, its etiology is not fully explained and interactions between various small molecules are still taken under account. The aim of this research was to investigate the mean serum concentration of vascular endothelial growth factor (VEGF), platelet activating factor (PAF), and eosinophil-derived neurotoxin (EDN) in relation to the disease activity and pruritus intensity in adult patients with CSU. Fifteen patients with CSU and 15 healthy subjects participated in this pilot study. Blood samples were taken to examine the mean serum levels of VEGF, PAF, and EDN by the enzyme-linked immunosorbent assay test (ELISA). The Urticaria Activity Score (UAS7) and The Visual Analogue Scale (VAS) were used to assess the disease activity and the pruritus intensity, respectively. Obtained results revealed that VEGF, PAF, and EDN concentrations were higher in patients with CSU compared with those of the control group, but only for VEGF it was statistically significant (p = 0.008). However, levels of all investigated cytokines were not significantly correlated neither with the disease activity nor with the pruritus intensity. Our results showed higher serum levels of VEGF, PAF, and EDN among CSU patients which may highlight a functional role of these cytokines in the disease’s pathogenesis. In contrast, VEGF, PAF, or EDN might not be useful to reflect the severity of symptoms.

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Section: Methodsmentioning

confidence: 99%

Serum Levels of Vascular Endothelial Growth Factor, Platelet Activating Factor and Eosinophil-Derived Neurotoxin in Chronic Spontaneous Urticaria—A Pilot Study in Adult Patients

Gomułka

Medrala

2022

IJMS

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Serum Concentration of IL-5 Receptor (IL-5R) and Associations with Disease Severity in Patients with Chronic Spontaneous Urticaria (CSU) and Atopic Dermatitis (AD)

Gomułka,

Tota,

Laska

et al. 2024

IJMS

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The immunological pathogenesis of atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) has not been fully elucidated yet. The aim of our research was to assess the serum concentration of interleukin-5 receptor (IL-5R) in relation to the disease activity and pruritus intensity in adult patients with AD and CSU. This pilot study included 45 participants (15 patients with AD, 15 patients with CSU, and 15 healthy controls). Blood samples were taken to examine the serum levels of IL-5R using the enzyme-linked immunosorbent assay (ELISA) test. The Scoring Atopic Dermatitis (SCORAD) index, the Urticaria Activity Score (UAS7), and the Visual Analogue Scale (VAS) were used to assess the disease activity and the pruritus intensity, respectively. Obtained results revealed that the IL-5R concentration was significantly higher in patients with CSU than in patients with AD and in the controls (p = 0.038). There was a positive correlation between the IL-5R level and the SCORAD index in patients with AD (r = −0.9, p = 0.047), which was not found for the CSU activity by UAS7 and with the pruritus severity by VAS in both examined groups of patients. Our findings underscore higher serum levels of IL-5R among CSU and AD patients, which may highlight its functional role in the pathogenesis of these diseases. In contrast, IL-5R might not be fully useful in reflecting the severity of symptoms. Although our results are promising, this study should be conducted on a larger cohort of patients.

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Острая Крапивница: Наиболее Значимые Аллергены У Детей И Современные Методы Лечения

Гацаева¹,

Махтиева²,

Гацаева³

2020

Вестник Медицинского Института

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В статье представлены наиболее значимые этиологические факторы развития острой крапивницы у детей, госпитализированных на стационарное лечение в ДКБ №2 г. Грозного. В зависимости от возраста пациента и формы заболевания в генезе превалируют различные этиологические факторы (аллергены). У детей грудного возраста преимущественно наблюдалась пищевая аллергия, у детей более старшего возраста – лекарственная, реже - инсектная и пищевая. Препаратом выбора является неседативный антигистаминный препарат второго поколения в рекомендуемых стандартных дозах. Тем не менее значительная часть пациентов требует добавления к терапии системных глюкокортикостероидов.

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Wytyczne EAACI/GA2LEN/EDF/WAO dotyczące definicji, klasyfikacji, diagnostyki i leczenia pokrzywki

Cited by 3 publications

References 143 publications

Serum Levels of Vascular Endothelial Growth Factor, Platelet Activating Factor and Eosinophil-Derived Neurotoxin in Chronic Spontaneous Urticaria—A Pilot Study in Adult Patients

Serum Levels of Vascular Endothelial Growth Factor, Platelet Activating Factor and Eosinophil-Derived Neurotoxin in Chronic Spontaneous Urticaria—A Pilot Study in Adult Patients

Serum Concentration of IL-5 Receptor (IL-5R) and Associations with Disease Severity in Patients with Chronic Spontaneous Urticaria (CSU) and Atopic Dermatitis (AD)

Острая Крапивница: Наиболее Значимые Аллергены У Детей И Современные Методы Лечения

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