The stronger than expected 21-cm absorption was observed by EDGES recently, and another anomaly of 8 Be transitions would be signatures of new interactions. These two issues may be related to each other, e.g., pseudoscalar A mediated fermionic millicharged dark matter (DM) and the 21-cm absorption could be induced by photon mediated scattering between MeV millicharged DM and hydrogen. This will be explored in this paper. For fermionic millicharged DMχχ with masses in a range of 2m A < 2m χ < 3m A , the p-wave annihilationχχ → A A would be dominant during DM freeze-out. The s-wave annihilation χχ → A, γ → e + e − is tolerant by constraints from CMB and the 21-cm absorption. The millicharged DM can evade constraints from direct detection experiments. The process of K + → π + π 0 with the invisible decay π 0 →χχ could be employed to search for the millicharged DM, and future high intensity K + sources, such as NA62, will do the job.