X-ray absorption study of ceria nanorods promoting the disproportionation of hydrogen peroxide

Wu, Tai; Zhou, Yunyun; Sabirianov, Renat; Mei, Wai Ning; Soo, Yun Liang; Cheung, Chin Li

doi:10.1039/c5cc10643e

Cited by 43 publications

(25 citation statements)

References 30 publications

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“…It should be noted that NF-κB was not activated in this latter phase, in contrast to that seen during day 1, illustrating specific mechanisms rather than an overall activation of redox-sensitive transcription factors. For the survival of a cancer cell, balancing between signaling and damaging effects of H 2 O 2 appears to be a crucial factor [38] . We have thus here helped to decipher the outcome of such redox signaling in terms of the localization and dynamics of Nrf2, HIF and NF-κB activation during the development of multicellular spheroids.…”

Section: Resultsmentioning

confidence: 99%

Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells

et al. 2017

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Cancer cells have an altered redox status, with changes in intracellular signaling pathways. The knowledge of how such processes are regulated in 3D spheroids, being well-established tumor models, is limited. To approach this question we stably transfected HCT116 cells with a pTRAF reporter that enabled time- and cell-resolved activity monitoring of three redox-regulated transcription factors Nrf2, HIF and NF-κB in spheroids enriched for cancer stem cells. At the first day of spheroid formation, these transcription factors were activated and thereafter became repressed. After about a week, both HIF and Nrf2 were reactivated within the spheroid cores. Further amplifying HIF activation in spheroids by treatment with DMOG resulted in a dominant quiescent stem-cell-like phenotype, with high resistance to stress-inducing treatments. Auranofin, triggering oxidative stress and Nrf2 activation, had opposite effects with increased differentiation and proliferation. These novel high-resolution insights into spatiotemporal activation patterns demonstrate a striking coordination of redox regulated transcription factors within spheroids not occurring in conventional cell culture models.

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Section: Resultsmentioning

confidence: 99%

Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells

et al. 2017

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“…Analysis of the XANES structure was performed using a peak fitting methodology. While peak fitting examples for the Ce L 3 edge XANES is commonly employed for standard transmission XANES analysis, [61][62][63][64] such an approach has not routinely been employed for analysis of HERFD-XANES. The association of the peaks to Ce(III) and Ce(IV) species was made in comparison to a NIST ceria reference material and previously reported associations and electronic transitions in the literature, 54,[64][65][66] and illustrated in Fig.…”

Section: Analysis Of the Ce L 3 -Edge Xas Experimentsmentioning

confidence: 99%

Temperature reversible synergistic formation of cerium oxyhydride and Au hydride: a combined XAS and XPDF study

Clark

Acerbi

Chater

et al. 2020

Phys. Chem. Chem. Phys.

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“…The rare earth elements occur in many minerals inside the earth's crust with quite higher abundance. Being actively investigated, cerium oxide is most imperative and well-known among light rare earth oxides, especially its use in catalysis [14]. Jons Jakob Berzelius and Wilhelm Hisinger were first who discovered elemental cerium in 1803.…”

Section: Introductionmentioning

confidence: 99%

Ceria as an Efficient Nanocatalyst for Organic Transformations

Naaz¹,

Farooq²,

Ahmad³

2019

Nanocatalysts

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Valuable chemicals, fuels and pharmaceuticals obtained by the transformation of raw materials have fascinated a lot of researchers in past few decades. However, to reduce problems related to these transformations different green, sustainable and economic techniques have been developed to carry out such organic transformations. Development of nanostructured catalysts has been preferred to accomplish heterogeneous catalytic organic transformations because of greater number of surface-active sites for catalytic processes, high catalyst recovery rate, environment friendly nature and their ease of synthesis. Besides the advances in nanocatalysis, certain challenges including not well-defined morphologies due to loss of control over it and loss of catalytic activity during operation need to be addressed. Ceria is actively investigated in field of catalysis. As a ubiquitous component in catalytic system, its inception is like an irreplaceable component in organic transformations. In this chapter, we appropriately reported various fabricating approaches to synthesize Cerium and CeO 2-rooted nanoparticles and cerium nanoparticles supported on various support materials, accompanied with multimetallic schemes that show notable contribution to the field of catalysis. This comprehensive chapter will provide an improved understanding of nanostructured CeO 2 and will provide deeper insight in the catalysis of Ce-based nanostructured materials and further widen their ambit of applications.

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X-ray absorption study of ceria nanorods promoting the disproportionation of hydrogen peroxide

Cited by 43 publications

References 30 publications

Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells

Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells

Temperature reversible synergistic formation of cerium oxyhydride and Au hydride: a combined XAS and XPDF study

Ceria as an Efficient Nanocatalyst for Organic Transformations

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