X-ray-Activated Simultaneous Near-Infrared and Short-Wave Infrared Persistent Luminescence Imaging for Long-Term Tracking of Drug Delivery

Abstract

Both short-wave infrared (SWIR: 900–1700 nm) and near-infrared (NIR: 650–900 nm) luminescence possess lower optical scattering and higher signal-to-noise in deep tissues than conventional luminescence, gaining increasing attention in biomedicine. Herein, we designed mesoporous silica-coated Yb-doped magnesium germanate nanoparticles (mMGOs) with excellent two-in-one NIR and SWIR persistent luminescence after X-ray irradiation by simply regulating the valence of rare-earth ions, which also possess high cargo loading and a controlled release profile in the tumor region. The investigations in vitro and in vivo showed that mMGOs were repeatedly activated to realize rechargeable persistent luminescence imaging for tracking cargo delivery in mice. Moreover, the stimulative drug-release profile inhibited tumor growth effectively. Both of the X-ray excited two-in-one NIR and SWIR persistent luminescence imaging not only allowed for rechargeable imaging of deep tumors but also achieved long-term tracking with a remarkable tumor inhibition effect.

Emerging Nanoagents for Medical X-ray Imaging

“…Medical X-ray imaging-guided radiotherapy has wide applications in clinical diagnosis, which provides accurate location information on complicated organs. X-ray-sensitive nanoagents are able to possess smart multifunctional capability through a combination of X-ray computed tomography with radiotherapy, photothermal therapy, and photoacoustic treatment. − For example, Li et al designed a novel class of merocyanine 540-loaded Gd 2 (WO 4 ) 3 :Tb nanoscintillators for X-ray-induced photothermal therapy to efficiently inhibit tumor growth under a low X-ray dose (Figure a) . In the gadolinium tungstate host of the as-synthesized nanoagents, the Gd elements in nanoagents were responsible for MRI with their high r 1 value after intratumoral (i.t.)…”

Sunlight activated ultra-stable long persistent luminescence glass ceramic for outdoor information display

“…Scintillators attract great attentions in the fields of security inspections, medical diagnosis and space exploration [40,41]. Especially, X-ray charged PeL is suitable for extension imaging and deep tissue bioimaging [42][43][44]. As shown in Fig.…”

Long‐Lived Second Near‐Infrared Luminescent Probes: An Emerging Role in Time‐Resolved Luminescence Bioimaging and Biosensing

“…Moreover, Ding et al constructed mesoporous silica-coated Yb-doped magnesium germanate nanoparticles (mMGOs) with excellent two-in-one NIR and NIR-II persistent luminescence after X-ray irradiation by simply adjusting the valence of RE ions. [42] Figure 5. A) Schematic illustration and Jablonski diagram of the emissive of dot probes, including QDs and B) AIE dots.…”