X-ray-activated, UVA persistent luminescent materials based on Bi-doped SrLaAlO4 for deep-Seated photodynamic activation

Abstract

The development of functionalized persistent-luminescent (PersL) materials is currently receiving intense interest for diverse applications. However, PersL materials emitting ultraviolet light in the 315–400 nm (UVA) range are lacking. Herein, a series of x-ray-activated PersL materials based on ABCO4-type structures with random cation arrangements are developed. Comprehensive experiments confirm that materials featuring random cation arrangements are sufficiently general to act as host materials for PersL. Experimental results indicate that as-synthesized SrLaXO4:Bi3+ (X = Al, Ga, In) powders have tunable PersL bands covering the UV-to-visible range after x-ray irradiation. Taking advantage of the depth-independent nature of x-ray illumination in tissues, UVA Persl composites using the matched photosensitizer g-C3N4 (SrLaAlO4:Bi@g-C3N4) are well suited for x-ray-activated photodynamic therapy, as proven by tests for singlet-oxygen (1O2) generation. Therefore, we suggest that the proposed concept be applied to discover additional functionalized PersL materials for clinical cancer therapy in the future.

Defect-induced deep red luminescence of CaGdAlO4-type layered perovskites: multi-cationic sites partial/full substitution and application in pc-LED and plant lighting

“…Wyckoff positions and atomic coordinates of CaGdAlO 4The cations, however, are not in complete order in the local structure;15 thus, disorder-induced traps can be easily formed in ABCO 4 compounds as was also stated in the study of longafterglow SrLaAlO 4 :Bi 3+ phosphors 20. In addition, during hightemperature reactions, due to the transfer of oxygen atoms, V O and O i occur simultaneously as depicted in the following reaction:21 CaGdAlO 4 !…”

Design of need-based phosphors and scintillators by compositional modulation in the ZnGa2−xAlxO4:Cr3+ spinel: pure compound versus solid solutions

“…1–5 The one wherein X-ray excitation is involved has an added advantage in bioimaging by virtue of its long penetration depth compared to UV and visible regions. 6–8 If one can design a phosphor, which demonstrates X-ray excited luminescence (XEL) together with the ability to decipher persistent XEL (p-XEL), it will be a game changer in the area of photodynamic therapy (PDT). 6–8…”

“…6–8 If one can design a phosphor, which demonstrates X-ray excited luminescence (XEL) together with the ability to decipher persistent XEL (p-XEL), it will be a game changer in the area of photodynamic therapy (PDT). 6–8…”

“…[1][2][3][4][5] The one wherein X-ray excitation is involved has an added advantage in bioimaging by virtue of its long penetration depth compared to UV and visible regions. [6][7][8] If one can design a phosphor, which demonstrates X-ray excited luminescence (XEL) together with the ability to decipher persistent XEL (p-XEL), it will be a game changer in the area of photodynamic therapy (PDT). [6][7][8] In the past years, chromium-activated ZnGa 2 O 4 is being considered as one of the most fascinating optical materials due to its outstanding and bright near-infrared photoluminescence, efficient persistent luminescence, long afterglow, high light harvesting efficiency, wavelength tunability, and superior photostability.…”

“…[6][7][8] If one can design a phosphor, which demonstrates X-ray excited luminescence (XEL) together with the ability to decipher persistent XEL (p-XEL), it will be a game changer in the area of photodynamic therapy (PDT). [6][7][8] In the past years, chromium-activated ZnGa 2 O 4 is being considered as one of the most fascinating optical materials due to its outstanding and bright near-infrared photoluminescence, efficient persistent luminescence, long afterglow, high light harvesting efficiency, wavelength tunability, and superior photostability. 2,3,[9][10][11][12][13] Consequently, ZnGa 2 O 4 :Cr 3+ (ZGOC) has found wide range applications in areas such as bioimaging, optical sensors, optical information storage, drug delivery, and plant growth.…”