X-ray and electron microscopy studies on the biodistribution and biomodification of iron oxide nanoparticles in Daphnia magna

Kwon, Daewoong; Nho, Hyun Woo; Yoon, Tae Hyun

doi:10.1016/j.colsurfb.2014.07.016

Cited by 27 publications

(14 citation statements)

References 33 publications

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“…However, there was no evidence (from the sections viewed) to suggest that either particle type was translocated into the cellular matrix. Similar distributions of NPs in Daphnia are reported in the literature for exposure to Fe 3 O 4 , α‐Fe 2 O 3 [ 48 ] and CuO [ 49 ] where they are not internalized.…”

Section: Resultssupporting

confidence: 80%

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Multigenerational Exposures of Daphnia Magna to Pristine and Aged Silver Nanoparticles: Epigenetic Changes and Phenotypical Ageing Related Effects

Ellis

Kissane

Hoffman

et al. 2020

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Engineered nanoparticles (NPs) undergo physical, chemical, and biological transformation after environmental release, resulting in different properties of the "aged" versus "pristine" forms. While many studies have investigated the ecotoxicological effects of silver (Ag) NPs, the majority focus on "pristine" Ag NPs in simple exposure media, rather than investigating realistic environmental exposure scenarios with transformed NPs. Here, the effects of "pristine" and "aged" Ag NPs are systematically evaluated with different surface coatings on Daphnia magna over four generations, comparing continuous exposure versus parental only exposure to assess recovery potential for three generations. Biological endpoints including survival, growth and reproduction and genetic effects associated with Ag NP exposure are investigated. Parental exposure to "pristine" Ag NPs has an inhibitory effect on reproduction, inducing expression of antioxidant stress related genes and reducing survival. Pristine Ag NPs also induce morphological changes including tail losses and lipid accumulation associated with aging phenotypes in the heart, abdomen, and abdominal claw. These effects are epigenetic remaining two generations post-maternal exposure (F2 and F3). Exposure to identical Ag NPs (same concentrations) aged for 6 months in environmentally realistic water containing natural organic matter shows considerably reduced toxicological effects in continuously exposed generations and to the recovery generations.

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Section: Resultssupporting

confidence: 80%

“…ROS has a direct and localized effect arising from the internalization of the Ag NPs and associated dissolved Ag, resulting in dysfunctional order and development of the cells/tissues leading to morphological changes [ 47 ] which may also have disturbed metabolism and chemical transformations. [ 48 ]…”

Section: Resultsmentioning

confidence: 99%

Multigenerational Exposures of Daphnia Magna to Pristine and Aged Silver Nanoparticles: Epigenetic Changes and Phenotypical Ageing Related Effects

Ellis

Kissane

Hoffman

et al. 2020

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“…However, some studies on uptake in relation to colloidal stability in the test medium show that agglomerates are taken up in larger amounts than their smaller counterparts (Asghari et al, 2012;Kwon et al, 2014) which may be explained by active filtration of these agglomerates as suggested in other studies (Rosenkranz et al, 2009;Zhao and Wang, 2010). In the present study, citAgNPs pass the active filtration limit for D. magna (of about 300-500 nm; (Brendelberger, Heinz, 1991;Geller and Müller, 1981;Kwon et al, 2014) after about 24 h of characterization while detAgNP remain below the limit, so that active filtration would be an exclusive mechanism for citAgNP.…”

Section: Discussionmentioning

confidence: 99%

“…The short-term experiments as well as the results for body burden in the chronic test show higher uptake of citAgNP than of detAgNP, which is in line with the higher toxicity observed for this kind of AgNP and may be caused by negative effects of AgNP after ingestion. Several studies addressed the uptake and the resulting effect of various NP on the midgut epithelium of Daphnia (Asghari et al, 2012;Feswick et al, 2013;Heinlaan et al, 2011;Khan et al, 2014;Kwon et al, 2014;Lovern et al, 2008;Rosenkranz et al, 2009; L. M. with different results related to the colloidal stability of NP: in some studies, mainly single NPs were found in the gut (Heinlaan et al, 2011;Khan et al, 2014;Lovern et al, 2008), while another study showed that more agglomerated NP caused higher damage in to the midgut epithelium (Kwon et al, 2014). However, the midgut epithelium is protected by the peritrophic membrane (PTM) and citAgNP were mainly larger than the PTM permeability of 130 nm (Avtsyn and Petrova, 1986;Hansen and Peters, 1997) while detAgNP remained below.…”

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confidence: 99%

Behavior and chronic toxicity of two differently stabilized silver nanoparticles to Daphnia magna

et al. 2016

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“…Recently, scanning transmission X-ray microscopy (STXM) has shown its capabilities and these may complement the current limitations of WM TEM by providing a better contrast mechanism and penetration depth with enough spatial resolution (Benzerara et al, 2004;Nelson et al, 2010;Kwon et al, 2014;Yang et al, 2014;Nho et al, 2016;Nho & Yoon, 2017). In particular, the contrast mechanism of STXM, which is based on the difference in X-ray absorption at the pre-and postedges, allows us to distinguish Ca-rich DGs, which may provide much clearer and more DG-specific contrast than the electron-density-based contrast of TEM.…”

Section: Introductionmentioning

confidence: 99%

Identification of Ca-rich dense granules in human platelets using scanning transmission X-ray microscopy

Trinh

Kwon

Gerelkhuu

et al. 2020

J Synchrotron Radiat

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Whole-mount (WM) platelet preparation followed by transmission electron microscopy (TEM) observation is the standard method currently used to assess dense granule (DG) deficiency (DGD). However, due to the electron-density-based contrast mechanism in TEM, other granules such as α-granules might cause false DG detection. Here, scanning transmission X-ray microscopy (STXM) was used to identify DGs and minimize false DG detection of human platelets. STXM image stacks of human platelets were collected at the calcium (Ca) L 2,3 absorption edge and then converted to optical density maps. Ca distribution maps, obtained by subtracting the optical density maps at the pre-edge region from those at the post-edge region, were used to identify DGs based on the Ca richness. DGs were successfully detected using this STXM method without false detection, based on Ca maps for four human platelets. Spectral analysis of granules in human platelets confirmed that DGs contain a richer Ca content than other granules. The Ca distribution maps facilitated more effective DG identification than TEM which might falsely detect DGs. Correct identification of DGs would be important to assess the status of platelets and DG-related diseases. Therefore, this STXM method is proposed as a promising approach for better DG identification and diagnosis, as a complementary tool to the current WM TEM approach.

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X-ray and electron microscopy studies on the biodistribution and biomodification of iron oxide nanoparticles in Daphnia magna

Cited by 27 publications

References 33 publications

Multigenerational Exposures of Daphnia Magna to Pristine and Aged Silver Nanoparticles: Epigenetic Changes and Phenotypical Ageing Related Effects

Multigenerational Exposures of Daphnia Magna to Pristine and Aged Silver Nanoparticles: Epigenetic Changes and Phenotypical Ageing Related Effects

Behavior and chronic toxicity of two differently stabilized silver nanoparticles to Daphnia magna

Identification of Ca-rich dense granules in human platelets using scanning transmission X-ray microscopy

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