X-ray crystal structure of a Cu(II) complex with the antiparasitic drug tinidazole, interaction with calf thymus DNA and evidence for antibacterial activity

Santra, Ramesh Chandra; Sengupta, Kushal; Dey, Rajdip; Shireen, Tahsina; Das, Piyal; Guin, Partha Sarathi; Mukhopadhyay, Kasturi; Das, Saurabh

doi:10.1080/00958972.2013.879647

Cited by 37 publications

(41 citation statements)

References 63 publications

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“…The τ factor defined for five-membered coordination spheres [34,35] is given as τ = (β -α) / 60, where β and α correspond to two largest angles around the metal. If τ = 0 the coordination is an ideal square pyramid and if τ = 1 the coordination is an ideal trigonal bipyramid.…”

Section: Computational Detailsmentioning

confidence: 99%

Synthesis, DNA binding and docking studies of copper(II) complexes containing modified phenanthroline ligands

Lakshmipraba

Arunachalam

Solomon³

et al. 2015

Journal of Coordination Chemistry

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Copper(II) complexes, [Cu(Hsal)(L)(ClO 4 )] (where Hsal = salicylaldehyde, 1: L = dpqC = dipyrido[3,2-a:2',3'-c](6,7,8,9-tetrahydro)phenazine) and 2: L = dppz = dipyrido[3,2-a:2',3'-c]phenazine]), were synthesized and characterized by elemental analysis and spectroscopic methods. Single crystal XRD on 1 confirms the presence of square pyramidal geometry around Cu(II). DNA interaction studies were performed for both the complexes using UV-visible, fluorescence and circular dichroism spectroscopic techniques and viscosity. These complexes bind with DNA through partial intercalation. Molecular docking studies confirm our experimental findings of mode of binding of our complexes with DNA.

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Section: Computational Detailsmentioning

confidence: 99%

Synthesis, DNA binding and docking studies of copper(II) complexes containing modified phenanthroline ligands

Lakshmipraba

Arunachalam

Solomon³

et al. 2015

Journal of Coordination Chemistry

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“…Since the torsional rotamer of HPIA has λ max at 280 nm that interferes with the absorption of free DNA, its interaction with c t DNA was not attempted by UV‐Vis spectroscopy . Hence, interaction of the trans isomer was only studied by this technique.…”

Section: Interaction Of Hpia With Calf Thymus Dnamentioning

confidence: 99%

Synthesis, characterization, photo physical properties of two isomeric forms of an azo dye supported by DFT calculations and their interaction with DNA

et al. 2016

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A new azo compound 2‐(2‐hydroxyphenylazo)‐indole‐3/‐acetic acid was synthesized. It is a yellow solid when freshly prepared but upon exposure to light turns red gradually. The change in color may be controlled by lowering the temperature or by keeping the compound in the dark. IR and mass spectroscopy of the two forms are similar while UV‐vis, NMR and HPLC are different suggesting isomerization. Fluorescence emission of the yellow compound at 370 nm following excitation at 280 nm is different from the red showing emission at 460 nm upon excitation at 350 nm. Spectroscopy and fluorescence lifetime data suggest change from the yellow form to red is reversible. DFT calculations show the yellow and red forms to be the torsional rotamer and the trans isomer respectively.The cis isomer was determined theoreticallybut could not be isolated.The trans is stable than the cis by 18.825 kcal mol−1.Interaction of the isomers with DNA was studied with the help of UV‐vis and fluorescence spectroscopy. Binding parameters suggest change in spatial orientation makes the trans compound a slightly better binder of DNA than the torsional rotamer.

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“…Most copper(II) carboxylates are dimeric and have paddle-wheel structures [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. From EXAFS data, it was inferred that the dimers were linked into a 1-D oligomeric chain in the solid state [17], and remained intact in solutions [18,19].…”

Section: Introductionmentioning

confidence: 99%

Structures and mesomorphism of complexes of tetrakis(4-chlorobenzoate-μ-O,O′)bis(ethanol)dicopper(II) with different N-donor ligands

Abdullah

Sharmin

Ozair

et al. 2015

Journal of Coordination Chemistry

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This article reports the synthesis and paddle-wheel structure of [Cu 2 (4-ClC 6 H 4 COO) 4 (EtOH) 2 ], and its reaction with pyridine (pyr), 2,2′-bipyridine (bpy), and 1,4,8,11-tetraazacyclotetradecane (cyclam) to form mononuclear covalent complexes, [Cu(4(4), respectively. The molecular structures of 2 and 3 were determined by single-crystal X-ray crystallography. Complexes 1 and 4 then reacted with 4-hexadecyloxypyridine (L) to form mesomorphic complexes, [Cu(4-ClC 6 H 4 COO) 2 (L) 2 (H 2 O)] (5) and [Cu (cyclam)(L) 2 ](4-ClC 6 H 4 COO) 2 (6), respectively. These complexes are potential molecular magnetic materials with tunable properties.

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X-ray crystal structure of a Cu(II) complex with the antiparasitic drug tinidazole, interaction with calf thymus DNA and evidence for antibacterial activity

Cited by 37 publications

References 63 publications

Synthesis, DNA binding and docking studies of copper(II) complexes containing modified phenanthroline ligands

Synthesis, DNA binding and docking studies of copper(II) complexes containing modified phenanthroline ligands

Synthesis, characterization, photo physical properties of two isomeric forms of an azo dye supported by DFT calculations and their interaction with DNA

Structures and mesomorphism of complexes of tetrakis(4-chlorobenzoate-μ-O,O′)bis(ethanol)dicopper(II) with different N-donor ligands

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