X-ray Diffraction Studies of Co(II), Sm(III) and Nd(III) Complexes with Gliclazide (N-(hexahydrocyclopenta[c] pyrrol-2(1H)-carbamoyl)-4-methylbenzenesulfonamide, An Oral Antidiabetic Drug

Abstract

Gliclazide(N-hexahydrocyclopentapyrrol-2-carbamoyl)-4-methylbenzenesulphonamide was used to synthesize Co(II),Sm(III) , Nd(III) complexes. Metal complxes were characterized by elemental analysis, IR, NMR,TGA. The crystal structure of complexes were further determined by X-ray diffraction method. The XRD data was used to calculate various parameters like crystal system, volume,density,porosity,particle size etc.which shows that the complexes of Co(II),Sm(III) and Nd(III) are octahedral structure.

Synthesis, Spectral characterization and X-ray Diffraction Studies of Cerium Complex of Glipizide, an Oral Antidiabetic Drug

“…X-ray diffraction studies also confirm the complex formation due to new bonds [26][27][28][29][30][31][32][33] . The number of peaks in glipizide are 15 while (GLP) 2 Ce are 4 ( fig 4.…”

Synthesis, Spectral and Biocidal Studies of Co(II), Ni(II) and Cu(II) Complexes of Hydrazone

“…The above observations strongly support the coordination of the ligand as uninegative bidentate ON donor sequence. The remaining coordination sites is satisfied by N-atom of neutral molecule such as ammonia, pyridine, α, β and γ-Picolines which also supported by low value of molar conductance of the complexes that lie in the range 4.1-6.9 Oh m -1 cm 2 mol -1 which indicate non-electrolytic 25 nature of the complexes.…”

“…The Co(II) complexes exhibit three electronic spectra bands, 9300, 14500 and 21500, assignable to transitions , 4 T 1g (F) → 4 T 2g (F), 4 T 1g (F) → 4 A 2g (F) and 4 T 1g (F) → 4 T 1g (P) respectively indicate an octahedral 25,26 geometry. The proposed geometry is further supported 27,28 by high µ eff value in the range 4.84-4.97B.M.…”

FTIR, UV-Vis, magnetic, mass spectral and XRD studies of Ni(II) complex with pioglitazone: An oral antidiabetic drug

“…New bands are found in the spectra of complexes in the region 507 cm -1 which is assigned to M-O stretching vibrations. The proposed structure for the isolated complex is also supported by IR absorptions [12][13][14][15][16][17][18] .…”

“…From the crystallographic data [21][22][23][24][25][26] unit cell parameters are obtained for Ni complex which attributed to orthorhombic crystal system. The particle size of pioglitazone-nickle complex is 19.871 microns respectively, which is calculated from X-ray line broadening using the Scherrer formula;…”