X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Ma, Li; Zou, Xiaoju; Bui, Brian; Chen, Wei; Song, Kwang Hyun; Solberg, Timothy D.

doi:10.1063/1.4890105

Cited by 112 publications

(78 citation statements)

References 28 publications

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“…109 In this work, tetrabromorhodamine-123 (TBrRh123) was conjugated to copper and cobalt co-doped ZnS (ZnS:Cu,Co). Results showed the combination had an efficient energy transfer and also displayed a long lasting afterglow, which could be a persistent light source for PDT even when the X-rays were turned off.…”

Section: X-ray Induced Photodynamic Therapymentioning

confidence: 99%

Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy

Kamkaew¹,

Chen²,

et al. 2016

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Achieving effective treatment of deep-seated tumors is a major challenge for traditional photodynamic therapy (PDT) due to difficulties in delivering light into the sub-surface. Thanks to its great tissue penetration, X-rays hold the potential to become an ideal excitation source for activating photosensitizers (PS) that accumulate in deep tumor tissue. Recently, a wide variety of nanoparticles have been developed for this purpose. The nanoparticles are not only designed as carriers for loading various kinds of PSs, but also can facilitate the activation process by transferring energy harvested from X-ray irradiation to the loaded PS. In this review, we focus on recent developments of nanoscintillators with high energy transfer efficiency, their rational designs, as well as potential applications in next generation PDT. Treatment of deep-seated tumors by using radioisotopes as an internal light source will also be discussed.

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Section: X-ray Induced Photodynamic Therapymentioning

confidence: 99%

Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy

Kamkaew¹,

Chen²,

et al. 2016

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“…It also should be pointed out that nanomedicine has become a hot area that under extensive investigations. [213][214][215][216][217][218][219][220][221][222][223][224][225][226][227][228][229] In addition to use nanoparticles for radiation enhancement discussed above, the combination of radiotherapy and photodynamic therapy via nanoparticles have been proposed and investigated. 220-229 Nanomedicine will have a bright future and will help to accelerate the progress toward ending cancers.…”

Section: Cscs Biomarkersmentioning

confidence: 99%

Active Targeting of Nano-Photosensitizer Delivery Systems for Photodynamic Therapy of Cancer Stem Cells

Lin¹,

Li²,

Wen³

et al. 2015

j biomed nanotechnol

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Cancer stem cells are believed to be the basis for tumor initiation, development, metastasis and recurrence; are resistant to most traditional therapies (e.g., chemotherapy and radiotherapy); and have the ability to self-renew, proliferate and differentiate. Photodynamic therapy may be a promising novel treatment for drug-resistant cancer stem cells because of the selectivity of the photosensitizer. One of the most important issues to overcome in photodynamic therapy is the photosensitizer-targeted delivery to tumor cells, especially cancer stem cells. Nano-photosensitizers comprising molecular photosensitizers and water-dispersible nanocarriers with or without moieties possessing the ability for specific binding to cancer cells or cancer stem cells are a promising strategy for active targeted photosensitizer delivery and photodynamic therapy-targeted therapy of tumors. In this review, we highlight current and future prospects for potential strategies based on nanoscience and nanotechnology for nano-photosensitizer-targeted delivery in the photodynamic therapy treatment of cancer cells, especially cancer stem cells.

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“…Zhang et al showed that a cyan persistent luminescence can be discerned in La 3 GaGe 5 O 16 [24]. Upon doping with Cr 3+ , the characteristic deep red emission is observed along with an enhancement of the intensity of the persistent luminescence.…”

mentioning

confidence: 99%

“…The delay can amount to minutes, hours or even days, which is exploited in emergency and safety signage, bioimaging, watch dials, toys, surveillance applications, counterfeiting and as light source for photodynamic activation to treat cancers and other diseases [1][2][3]. The defects, or traps, present in a persistent phosphor can store excitation energy under the form of trapped charge carriers.…”

Section: Introductionmentioning

confidence: 99%

Feature issue introduction: persistent and photostimulable phosphors – an established research field with clear challenges ahead

Smet¹,

Viana²,

Tanabe³

et al. 2016

Opt. Mater. Express

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Persistent phosphors have the ability to emit light long after the excitation has ended, typically by using thermal energy to liberate previously trapped charges. Alternatively, also photons can be used for the detrapping, leading to optically stimulated luminescence (OSL). This particular field of phosphor research has seen a strong expansion over the past two decades, with a steady growth of the materials library, an improved structural and luminescence characterization and the development of novel applications. Despite this success, clear challenges lie ahead in terms of a deeper understanding of the trapping mechanism and an associated optimization of the energy storage capacity being crucial for many applications. This focus issue "Persistent and Photostimulable Phosphors" within Optical Materials Express features papers presented at the third International Workshop on Persistent and Photostimulable Phosphors (IWPPP 2015) held at the University of Texas at Arlington. 19326-19332 (2015

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X-ray excited ZnS:Cu,Co afterglow nanoparticles for photodynamic activation

Cited by 112 publications

References 28 publications

Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy

Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy

Active Targeting of Nano-Photosensitizer Delivery Systems for Photodynamic Therapy of Cancer Stem Cells

Feature issue introduction: persistent and photostimulable phosphors – an established research field with clear challenges ahead

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