X-ray induced singlet oxygen generation by nanoparticle-photosensitizer conjugates for photodynamic therapy: determination of singlet oxygen quantum yield

Clement, Sandhya; Deng, Wei; Camilleri, Elizabeth; Wilson, Brian C.; Goldys, Ewa M.

doi:10.1038/srep19954

Cited by 131 publications

(101 citation statements)

References 47 publications

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“…135 The results showed that the quantum yield of X-ray induced 1 O 2 generation was 0.79 ± 0.05 for the most efficient conjugate with 31 VP molecules per nanoparticle. This conjugate converts 1 O 2 molecules at the level of 1.2 × 10 8 to 2.0 × 10 9 per cell upon exposure to high energy (6 MeV) radiation with a radiotherapeutic dose of 60 Gy.…”

Section: Depth Penetrationmentioning

confidence: 97%

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment.

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Section: Depth Penetrationmentioning

confidence: 97%

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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“…These values are comparable to the threshold for tumor spheroids by 1 O 2 species (~2 × 10 8 molecules per cell) as literature reported. [21] …”

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confidence: 99%

Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy

et al. 2017

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Reactive oxygen species (ROS) induced apoptosis is a widely practiced strategy for cancer therapy. Although photodynamic therapy (PDT) takes advantages of spatial-temporal control of ROS generation, the meticulous participation of light, photosensitizer, and oxygen greatly hinders the broad application of PDT as a first-line cancer treatment option. Here, we developed an activatable system enabling tumor-specific singlet oxygen (1O2) generation for cancer therapy, based on a Fenton-like reaction between linoleic acid hydroperoxide (LAHP) tethered on iron oxide nanoparticles (IO NPs) and the released iron(II) ions from IO NPs under acidic-pH condition. We show that the IO-LAHP NPs are able to induce efficient apoptotic cancer cell death both in vitro and in vivo through tumor-specific 1O2 generation and subsequent ROS mediated mechanism. This study demonstrates the effectiveness of modulating biochemical reactions as a ROS source to exert cancer death, which may pave the way to develop novel strategies for cancer therapy.

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“…X-ray-excited PDT, based on scintillating nanoparticles, was first introduced by Chen and Zhang [12] in 2006 and recently several studies have demonstrated this effect into proof of concept [8, 13–15]. For future clinical applications, the photosensitizers can be loaded onto nanoparticles, which can lead to a more direct and specific localization of the photosensitizer to the brain tumor sites and increase the efficiency and selectivity in treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Although scintillating nanoparticles have been studied in PDT [13, 15, 18], to the best of the authors’ knowledge, the non-invasive PDT concept of using scintillating nanoparticles in brain cancer cells has not been described.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive Photodynamic Therapy in Brain Cancer by Use of Tb3+-Doped LaF3 Nanoparticles in Combination with Photosensitizer Through X-ray Irradiation: A Proof-of-Concept Study

Chen

Jenh

et al. 2017

Nanoscale Res Lett

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The use of photodynamic therapy (PDT) in the treatment of brain cancer has produced exciting results in clinical trials over the past decade. PDT is based on the concept that a photosensitizer exposed to a specific light wavelength produces the predominant cytotoxic agent, to destroy tumor cells. However, delivering an efficient light source to the brain tumor site is still a challenge. The light source should be delivered by placing external optical fibers into the brain at the time of surgical debulking of the tumor. Consequently, there exists the need for a minimally invasive treatment for brain cancer PDT. In this study, we investigated an attractive non-invasive option on glioma cell line by using Tb3+-doped LaF3 scintillating nanoparticles (LaF3:Tb) in combination with photosensitizer, meso-tetra(4-carboxyphenyl)porphyrin (MTCP), followed by activation with soft X-ray (80 kVp). Scintillating LaF3:Tb nanoparticles, with sizes of approximately 25 nm, were fabricated. The particles have a good dispersibility in aqueous solution and possess high biocompatibility. However, significant cytotoxicity was observed in the glioma cells while the LaF3:Tb nanoparticles with MTCP were exposed under X-ray irradiation. The study has demonstrated a proof of concept as a non-invasive way to treat brain cancer in the future.

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X-ray induced singlet oxygen generation by nanoparticle-photosensitizer conjugates for photodynamic therapy: determination of singlet oxygen quantum yield

Cited by 131 publications

References 47 publications

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy

Non-invasive Photodynamic Therapy in Brain Cancer by Use of Tb3+-Doped LaF3 Nanoparticles in Combination with Photosensitizer Through X-ray Irradiation: A Proof-of-Concept Study

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