X-ray luminescence of core-shell structured SiO2/Lu2O3:Eu3+ and SiO2/Lu2Si2O7:Eu3+ particles

Yermolayeva, Yu. V.; Korshikova, T.I.; Tolmachev, A. V.; Yavetskiy, R.P.

doi:10.1016/j.radmeas.2011.02.020

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…In contrast to conventional CAs, which are small iodinated molecules, engineered nanosized CAs containing high‐Z elements have prolonged blood circulation and enhanced tumor accumulation leading to better cancer detection . Scintillating nanoparticles (SCNPs) can convert X‐ray radiation into UV–vis light, which enables X‐ray‐excited optical luminescence (XEOL) imaging. XEOL offers higher resolution and sensitivity than UV–vis or near‐infrared (NIR) light‐excited luminescence imaging methods, thus promising enormous application potential.…”

Section: Introductionmentioning

confidence: 99%

Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

et al. 2019

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treat cancer patients; however, it can cause severe systemic toxicity and immunesystem depression due to its nonspecific nature. [2][3][4] As a noninvasive therapeutic modality, radiotherapy (RT) with assistance from image guidance/positioning can be used to deliver X/γ-ray radiation to tumors. [5][6][7][8] This enables radiation oncologists to target malignant tissues for precise cancer therapy [9][10][11] while minimizing radiation dose delivered to surrounding normal tissues. However, RT efficacy can be attenuated by factors like salient hypoxia found in solid tumors. [12][13][14][15] Moreover, some cancer subtypes and cancer stem cells exhibit high resistance to X-ray radiation. [16] Consequently, the development of radiosensitizers that can sensitize hypoxic or radio-resistant tumors to X-ray radiation [17][18][19][20] has become an area of intense research.The emerging radiosensitizers can be classified into three groups: gasotransmitters (e.g., O 2 , NO, H 2 S, etc.), [21][22][23][24][25] anticancer drugs (e.g., paclitaxel (PTX), docetaxel (Dtxl), topotecan (TPT), etc.), [26][27][28] and high-Z elements (e.g., Au, Ba, Bi, Pt, W, etc.). [29][30][31][32][33][34][35] The gasotransmitters can mimic the radiosensitizing effect of oxygen and downregulate hypoxia-inducible factor-1 alpha (HIF-1α) expression, [23] while anticancer drugs can induce cancer cells to enter the G2/M phase which is the most radiation-sensitive cell-cycle phase. [36] High-Z elements are known for scattering one X-ray beam into several beams to concentrate more radiation on tumors for aggravated radiation damage. [37,38] This radiation dose-amplification effect is based on the Compton scattering mechanism. [39] All of these radiosensitizers are usually loaded or engineered into nanocarriers for tumor-specific delivery or by passive tumor accumulation via the enhanced permeability and retention (EPR) effect. [40] Heretofore, a great number of nanomaterials have been synthesized to pave the way for high-performance radiosensitization for RT enhancement. [41][42][43][44] Despite the appreciable progress achieved in X-ray radiation sensitization/enhancement, RT as a monotherapy generally fails to eliminate the whole tumor as cancer cells can undergo DNA-repair and regrowth. [45,46] As such, current research is gradually shifting from RT monotherapy to X-rayexcited multimodal therapy. This means that two or more therapeutic modalities are simultaneously activated by X-ray to yield synchronous/synergistic anticancer effects. [47][48][49] For example, it has been shown that high-energy X-ray irradiation can triggerThe advancements in nanotechnology have created multifunctional nanomaterials aimed at enhancing diagnostic accuracy and treatment efficacy for cancer. However, the ability to target deep-seated tumors remains one of the most critical challenges for certain nanomedicine applications. To this end, X-ray-excited theranostic techniques provide a means of overcoming the limits of light penetration and tissue attenuation. Herein, a comprehe...

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Section: Introductionmentioning

confidence: 99%

Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

et al. 2019

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“…When used as a core material, SiO 2 has very strong affinity due to the Si–OH groups and external hydrogen bonds on its surface, so SiO 2 bonds easily with different materials through chemical bonds or electrostatic interactions. Coated nanomaterials have been a hot topic of research in recent years, and nanomaterials comprising a SiO 2 core coated with inorganic rare earth materials have been studied . However, layers of organic rare earth complexes have been reported only recently.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and luminescence of europium perchlorate with MABA‐Si complex and coating structure SiO₂@Eu(MABA‐Si) luminescence nanoparticles

Bai

et al. 2016

Luminescence

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This article reports a novel category of coating structure SiO @Eu(MABA-Si) luminescence nanoparticles (NPs) consisting of a unique organic shell, composed of perchlorate europium(III) complex, and an inorganic core, composed of silica. The binary complex Eu(MABA-Si) ·(ClO ) ·5H O was synthesized using HOOCC H N(CONH(CH ) Si(OCH CH ) ) (MABA-Si) and was used as a ligand. Furthermore, the as-prepared silica NPs were successfully coated with the -Si(OCH CH ) group of MABA-Si to form Si-O-Si chemical bonds by means of the hydrolyzation of MABA-Si. The binary complexes were characterized by elemental analysis, molar conductivity and coordination titration analysis. The results indicated that the composition of the binary complex was Eu(MABA-Si) ·(ClO ) ·5H O. Coating structure SiO @Eu(MABA-Si) NPs were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM) and infrared (IR) spectra. Based on the SEM and TEM measurements, the diameter of core-SiO particles was ~400 and 600 nm, and the thickness of the cladding layer Eu(MABA-Si) was ~20 nm. In the binary complex Eu(MABA-Si) ·(ClO ) ·5H O, the fluorescence spectra illustrated that the energy of the ligand MABA-Si transferred to the energy level for the excitation state of europium(III) ion. Coating structure SiO @Eu(MABA-Si) NPs exhibited intense red luminescence compared with the binary complex. The fluorescence lifetime and fluorescence quantum efficiency of the binary complex and of the coating structure NPs were also calculated. The way in which the size of core-SiO spheres influences the luminescence was also studied. Moreover, the luminescent mechanisms of the complex were studied and explained.

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“…They can emit photons in the UV, visible, and NIR regions and have been considered to be a suitable choice for scintillating materials because they emit visible photons when irradiated with γ- or X-rays . Great efforts have been devoted to developing nanophosphors for X-ray luminescence optical tomography (XLOT) applications. − Recently, NaGdF 4 -doped Eu 3+ nanoparticles were synthesized and studied systematically for applications in X-ray-excited luminescence . The Gd 3+ –Eu 3+ host–dopant combination is considered to be the best combination for a down-conversion system because the emission energy transitions within Gd 3+ can resonantly couple to the excited state of Eu 3+ ions.…”

Section: Brief Introduction Of X-ray Technologymentioning

confidence: 99%

Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy

Kamkaew¹,

Chen²,

et al. 2016

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Achieving effective treatment of deep-seated tumors is a major challenge for traditional photodynamic therapy (PDT) due to difficulties in delivering light into the sub-surface. Thanks to its great tissue penetration, X-rays hold the potential to become an ideal excitation source for activating photosensitizers (PS) that accumulate in deep tumor tissue. Recently, a wide variety of nanoparticles have been developed for this purpose. The nanoparticles are not only designed as carriers for loading various kinds of PSs, but also can facilitate the activation process by transferring energy harvested from X-ray irradiation to the loaded PS. In this review, we focus on recent developments of nanoscintillators with high energy transfer efficiency, their rational designs, as well as potential applications in next generation PDT. Treatment of deep-seated tumors by using radioisotopes as an internal light source will also be discussed.

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X-ray luminescence of core-shell structured SiO2/Lu2O3:Eu3+ and SiO2/Lu2Si2O7:Eu3+ particles

Cited by 14 publications

References 16 publications

Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

Synthesis, characterization and luminescence of europium perchlorate with MABA‐Si complex and coating structure SiO₂@Eu(MABA‐Si) luminescence nanoparticles

Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy

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X-ray luminescence of core-shell structured SiO2/Lu2O3:Eu3+ and SiO2/Lu2Si2O7:Eu3+ particles

Cited by 14 publications

References 16 publications

Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

Breaking the Depth Dependence by Nanotechnology‐Enhanced X‐Ray‐Excited Deep Cancer Theranostics

Synthesis, characterization and luminescence of europium perchlorate with MABA‐Si complex and coating structure SiO2@Eu(MABA‐Si) luminescence nanoparticles

Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy

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Synthesis, characterization and luminescence of europium perchlorate with MABA‐Si complex and coating structure SiO₂@Eu(MABA‐Si) luminescence nanoparticles