X-ray Reflectivity Study of the Interaction of an Imidazolium-Based Ionic Liquid with a Soft Supported Lipid Membrane

Bhattacharya, Gourav; Giri, Rajendra P.; Saxena, Hima; Agrawal, Ved Varun; Gupta, Ashish; Mukhopadhyay, Mrinmay K.; Ghosh, Sajal K.

doi:10.1021/acs.langmuir.6b03192

Cited by 67 publications

(91 citation statements)

References 87 publications

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“…POPC domains in gray, water layers in red, [C 4 Shrinkage of the phospholipid bilayer thickness upon interaction with RTILs with water has been also confirmed by X-ray experiments (Bhattacharya et al 2017, Kontro et al 2016). In one case (Bhattacharya et al 2017), single supported bilayers of DPPC (a zwitterionic lipid) interacting with aqueous solutions of [bmim] [BF 4 ] have been measured by means of X-ray reflectivity at several RTIL concentrations. As an additional result, the bilayer thickness seems to decrease faster with increasing RTIL concentration, although better error bars are needed to reach a final conclusion (see Table 1 of Bhattacharya et al 2017).…”

Section: Introductionmentioning

confidence: 72%

“…5 Schematic view of one of the sample configurations used in our MD simulations (Benedetto et al 2015). POPC domains in gray, water layers in red, [C 4 Shrinkage of the phospholipid bilayer thickness upon interaction with RTILs with water has been also confirmed by X-ray experiments (Bhattacharya et al 2017, Kontro et al 2016). In one case (Bhattacharya et al 2017), single supported bilayers of DPPC (a zwitterionic lipid) interacting with aqueous solutions of [bmim] [BF 4 ] have been measured by means of X-ray reflectivity at several RTIL concentrations.…”

Section: Introductionmentioning

confidence: 82%

“…This article is part of a Special Issue on 'IUPAB Edinburgh Congress' edited by Damien Hall (v) Penetrate, create pores, and destroy biomembranes (Benedetto et al 2014b, Bhattacharya et al 2017, Evans 2008, Yoo et al 2014, b, Wang et al 2015a, b, 2016Drücker et al 2017; and (vi) Dissolve cellulose and other complex polysaccharides (Youngs et al 2011, Zhang et al 2017, Cheng et al 2011, Liu et al 2010.…”

Section: Introductionmentioning

confidence: 99%

“…In one case (Bhattacharya et al 2017), single supported bilayers of DPPC (a zwitterionic lipid) interacting with aqueous solutions of [bmim] [BF 4 ] have been measured by means of X-ray reflectivity at several RTIL concentrations. As an additional result, the bilayer thickness seems to decrease faster with increasing RTIL concentration, although better error bars are needed to reach a final conclusion (see Table 1 of Bhattacharya et al 2017). The effect of concentration has also been studied by monitoring the survival percentage of E. coli versus the concentration of [bmim] [BF 4 ], which shows an inverse correlation relationship (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Room-temperature ionic liquids meet bio-membranes: the state-of-the-art

Benedetto

2017

Biophys Rev

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Room-temperature ionic liquids (RTIL) are a new class of organic salts whose melting temperature falls below the conventional limit of 100°C. Their low vapor pressure, moreover, has made these ionic compounds the solvents of choice of the so-called green chemistry. For these and other peculiar characteristics, they are increasingly used in industrial applications. However, studies of their interaction with living organisms have highlighted mild to severe health hazards. Since their cytotoxicity shows a positive correlation with their lipophilicity, several chemical-physical studies of their interactions with biomembranes have been carried out in the last few years, aiming to identify the molecular mechanisms behind their toxicity. Cation chain length and anion nature of RTILs have seemed to affect lipophilicity and, in turn, their toxicity. However, the emerging picture raises new questions, points to the need to assess toxicity on a case-by-case basis, but also suggests a potential positive role of RTILs in pharmacology, bio-medicine and bio-nanotechnology. Here, we review this new subject of research, and comment on the future and the potential importance of this emerging field of study.

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Section: Introductionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Room-temperature ionic liquids meet bio-membranes: the state-of-the-art

Benedetto

2017

Biophys Rev

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“…Sajal Ghosh (Shiv Nadar University, India) presents his recent X-ray reflectivity study on the interaction between an imidazolium-based IL with a soft supported lipid bilayer that is a well-accepted model for biomembranes (Bhattacharya et al 2017). In this study, Ghosh and co-workers were able to probe how the structure and the overall stability of the supported lipid bilayer are affected by the interaction with the IL.…”

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confidence: 99%

Overview of the “Ionic Liquids meet Biomolecules” session at the 19th international IUPAB and 11th EBSA congress

Benedetto

Galla

2017

Biophys Rev

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Room temperature ionic liquids (ILs) (Welton 1999) are a vast class of ionic systems consisting of an organic cation and either an organic or inorganic anion, whose melting temperature falls below the conventional limit of 100°C, making these compounds liquid at or near room temperature. The thermal and chemical stability of these systems make them the basis of what is called Bgreen chemistry^ (Earle and Seddon 2000). Several biochemical studies, however, have highlighted their potential toxicity to organisms, a toxicity which, in turn, is also a measure of their affinity for bio-molecules. This property has stimulated several chemical-physical studies on the interaction between ILs and basic biological systems. In recent decades, it has been observed that selected ILs are able: (1) to kill bacteria and cancer cells while leaving eukaryotic healthy cells almost unaffected; (2) to extract, purify and even preserve DNA at ambient temperature; (3) to stabilize proteins and enzymes; (4) to either favour or prevent protein amyloidogenesis; (5) to penetrate and eventually disrupt biomembranes via extended poration; and (6) to dissolve polysaccharides and cellulose. A recent overview of the subject is reported in two reviews authored by Benedetto and Ballone (2016a, b).The aim of the BIonic Liquid meet Biomolecules^session of the IUPAB-EBSA congress was to present an up-to-date overview of this new and intriguing subject of research which has potential applications in several fields, ranging from biomedicine, pharmacology, and material science to bionanotechnologies.Pannuru Venkatesu (University of Delhi, India) focuses on the interaction between ionic liquids and proteins (Meena et al. 2016;Jha and Venkatesu 2016), arguing that studies of interaction between proteins and different ILs in aqueous solution are comparatively more important than those in pure ILs. The results of these investigations suggest that the ILwater-protein interaction is a complex balance of different contributions by the different components, which is not possible to predict a priori. There is sufficient evidence in the literature to lead to the conclusion that the interaction between proteins and ILs depends on the protein as well as on the cations and anions present in the ILs.Antonio Benedetto (University College Dublin, Ireland, and Paul Scherrer Institut, Switzerland) presents results from joint experimental and computational studies on the interaction between ILs and (model) biomembranes (Benedetto 2017;Benedetto et al. 2015, Benedetto et al. 2014. Combining neutron scattering and computer simulations these studies show how it is possible to describe the mechanisms of interaction at the molecular level: IL cations penetrate the biomembrane, finding a preferential location between the tails and the heads of the phospholipids. The penetration is driven by the Coulombic attraction between the IL cations and one of the most electronegative oxygen atoms in the phospholipid heads, and is stabilized by dispersion forces between the lipids and th...

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Morphological and Interaction Characteristics of Surface‐Active Ionic Liquids and Palmitic Acid in Mixed Monolayers

et al. 2020

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A series of water soluble, surface‐active ionic liquids (SAILs), namely, 1‐alkyl‐3‐methyl imidazolium chlorides ([Cn‐mim]Cl) and their mixtures with palmitic acid (PA) are investigated in Langmuir monolayers and Langmuir–Blodgett films. It is inferred from the surface pressure‐area isotherms that C16‐mim‐IL mixes non‐ideally with PA and stabilizes the binary mixed films. In addition, the residence of mim‐IL at the water surface is enhanced as a function of the increasing alkyl side chain length. Generally, the compressional moduli values decrease upon increasing the content of the mim‐ILs over a wide range of compositions. Furthermore, film relaxation measurements indicate that the IL component is selectively excluded from the mixed films upon achieving a certain target pressure. Brewster angle microscope images demonstrate minimal changes on the PA domains in the presence of either C4‐ and C8‐mim‐ILs, whereas presence of the hexadecyl counterpart results in the formation of condensed sheets. Atomic force microscopy imaging of deposited films show the formation of propeller‐like aggregates when C8‐ or C16‐mim‐IL is present in the mixed films.

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X-ray Reflectivity Study of the Interaction of an Imidazolium-Based Ionic Liquid with a Soft Supported Lipid Membrane

Cited by 67 publications

References 87 publications

Room-temperature ionic liquids meet bio-membranes: the state-of-the-art

Room-temperature ionic liquids meet bio-membranes: the state-of-the-art

Overview of the “Ionic Liquids meet Biomolecules” session at the 19th international IUPAB and 11th EBSA congress

Morphological and Interaction Characteristics of Surface‐Active Ionic Liquids and Palmitic Acid in Mixed Monolayers

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