X‐Ray‐Responsive Zeolitic Imidazolate Framework‐Capped Nanotherapeutics for Cervical Cancer‐Targeting Radiosensitization (Adv. Funct. Mater. 13/2023)

Abstract

Cervical Cancer‐Targeting Radiosensitization In article number 2213364, Xueqiong Zhu, Tianfeng Chen, and co‐workers report zeolitic imidazolate framework‐capped Mn3O4 nanoparticles modified with folic acid with X‐ray response properties. This nanoparticle possesses a high oxygen vacancies rate and Mn3+ ratio, promoting H2O2 and glutathione degradation, producing more singlet oxygen under X‐ray, increasing reactive oxygen species level, and alleviating hypoxia within the tumor microenvironment. It shows promising potential for anti‐cervical cancer therapeutics.

Constructing Amorphous‐Crystalline Interfacial Bifunctional Site Island‐Sea Synergy by Morphology Engineering Boosts Alkaline Seawater Hydrogen Evolution

“…The intrinsic catalytic activity of the catalyst for the HER is typically assessed in terms of the hydrogen adsorption‐free energy (∆G H* ). [ 27 ] An ideal catalyst should exhibit an optimal ∆G H* value close to 0 eV, indicating a suitable strength of H adsorption/desorption during the catalytic process. [ 28 ] In this study, PdCo‐Co 3 S 4 and Co 3 S 4 (220) were employed as models (Figure S14 , Supporting Information) to investigate potential adsorption sites for the H* intermediate with various active atoms.…”

Nanostructure engineering of ruthenium-modified electrocatalysts for efficient electrocatalytic water splitting

“…The strong interaction of heterogeneous components with different physical and chemical properties enables charge redistribution at the interface and thus improves the catalytic activity and stability of interfacial nanomaterials. 225–229 Moreover, the electron transfer and the transportation of adsorbents/intermediates on active surfaces can be facilitated by the construction of a heterogeneous interface, which contributes to enhancing the accessibility of reactants. Recently, interfacial structural engineering of electrode materials has become a hotspot for electrocatalysis.…”

Stimuli‐Responsive Nanoradiosensitizers for Enhanced Cancer Radiotherapy

“…Zhu and colleagues developed a radiosensitizer (FA‐Mn 3 O 4 @ZIF‐8) for efficient cervical cancer‐targeting radio‐sensitization by combining zeolitic imidazolate framework (ZIF‐8), Mn 3 O 4 , and folic acid (FA) as targeting molecules. [ 214 ] The FA‐ Mn 3 O 4 @ZIF‐8 radiosensitizer demonstrated several responsive properties, making it highly effective in sensitizing RT for cervical cancer cells (Figure 12G). The presence of the ZIF‐8 caps on Mn 3 O 4 increased the catalytic ability of H 2 O 2 and GSH, resulting in the generation of more singlet oxygen under X‐ray irradiation.…”