X-ray screening seems to reduce gastric cancer mortality by half in a community-controlled trial in Costa Rica

Rosero-Bixby, Luis; Sierra, Rosa A.

doi:10.1038/sj.bjc.6603729

Cited by 28 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The perspectives for the control of gastric cancer are uncertain because therapeutic advances are insufficient, the pre-clinical results of efforts to develop vaccines against H. pylori have been disappointing 31 ; and the early detection of gastric cancer in Latin America has shown unreliable results 32 , 33 and low cost-effectiveness 34 . During the first stages of tumor growth, cancer is clinically silent.…”

Section: Discussionmentioning

confidence: 99%

“…Las perspectivas para el control del cáncer gástrico son inciertas porque son insuficientes los avances terapéuticos, los resultados pre-clínicos de los esfuerzos para el desarrollo de vacunas contra H. pylori , han sido decepcionantes 31 ; y la detección temprana del cáncer gástrico en Latinoamérica ha mostrado resultados discordantes 32 , 33 y baja costo-efectividad 34 . Teniendo en cuenta que durante las primeras etapas del tumor es clínicamente silente, una alternativa para su control es la prevención primaria mediante la erradicación de la infección por H. pylori que puede reducir el riesgo de desarrollar cáncer gástrico en personas sin lesiones precursoras 30 , 34 , 35 .…”

Section: Discussionunclassified

See 1 more Smart Citation

Información fiable para el control del cáncer en Cali, Colombia

Bravo¹,

García²,

Collazos

et al. 2018

Colomb Med

View full text Add to dashboard Cite

Background: The Cali Population Cancer Registry (RPCC) has been in continuous operation since 1962 with the objective of producing valid statistics on the incidence of cancer, its patterns, trends and survival rates.Methods: During the period 2008-2012, 23,046 new cases were registered and during 2011-2015 there were 12,761 cancer deaths. The trend of the rates was described with the APC average annual change rate and with the Joinpoint analysis. We analyzed the individual data of 38,671 adults (15-99 years) diagnosed with cancer between 1995-2009, and we calculated the standardized net survival by age for the 14 most common cancer body sites, using the Pohar-Perme method.Results: Prostate and breast cancer were the first cause of cancer morbidity. The incidence rates in these were susceptible to early detection, tumors stabilized after decades of growth, while an increase in the incidence of colon cancer and papillary thyroid carcinoma was observed. The incidence rates of cervical and stomach cancer and conditions related to infectious agents decreased, although the number of absolute cases increased, due to the growth and aging of the population. Gastric cancer was responsible for the highest number of cancer related deaths. The types of cancer related to tobacco consumption (lung, oral cavity, esophagus, pancreas, urinary bladder) showed low numbers and a tendency to decrease. During the period 2000-2004, the 5-year net survival improved for cancers of the breast, cervix, prostate, melanoma and thyroid, although in the period 2005-2009 a stagnation was observed. In stomach, liver and lung cancer, the 5-year net survival was less than 15%. The 5-year overall survival in children was 51.0% (95% CI: 47.5, 54.3) and in adolescents 44.6% (95% CI: 36.0, 52.8).Comment: RPCC has been an advisor to the Colombian government in the evaluation of CPRs in the country and its data has contributed significantly to different aspects of cancer control in Colombia.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionunclassified

Información fiable para el control del cáncer en Cali, Colombia

Bravo¹,

García²,

Collazos

et al. 2018

Colomb Med

View full text Add to dashboard Cite

show abstract

“…Studies on gastric cancer screening considered reduction in gastric cancer mortality or intermediate outcomes (eg, gastric cancer detection rate) as outcomes. Observational studies suggested a statistically significant reduction of gastric cancer mortality for direct gastroscopy (odds ratio (OR) = 0.72, 95% CI 0.54 – 0.97) and X–ray (48–59%, P < 0.05) [ 30 , 34 ]. Screening with photofluorography was not found to reduce mortality from gastric cancer [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Strategies for prevention of gastrointestinal cancers in developing countries: a systematic review

Shams

Haug

2017

Journal of Global Health

View full text Add to dashboard Cite

BackgroundGastrointestinal cancers account for one third of total cancer incidence and mortality in developing countries. To date, there is no systematic synthesis of evidence regarding strategies to prevent gastrointestinal cancers in developing countries. We aimed to provide a systematic overview of studies evaluating strategies for prevention or early detection of the three most common gastrointestinal cancers (gastric, liver and colorectal cancer) in developing countries.MethodsWe searched MEDLINE, Web of Science and WHO Global Index Medicus databases for relevant articles published until October 2016 using combinations of the search terms “gastrointestinal”, “digestive system”, “gastric”, “liver”, “colorectal”, “cancer”, “prevention”, “early detection” and “developing country” (including names).ResultsOverall, 73 articles met the inclusion criteria, providing information on short– and long–term outcomes (up to 30 years) from various intervention studies (∼45% randomized). Trials on hepatitis B vaccination consistently showed vaccine efficacy over time and indicated long–term preventive effects on liver cancer incidence that start to become measurable at the population level. Studies on anti–H. pylori treatment suggested a reduction in gastric cancer incidence reaching statistical significance after long–term follow–up, while evidence regarding a preventive effect in persons with precancerous lesions is still inconclusive. The studies regarding colorectal cancer focused on early detection, ∼90% of which were restricted to intermediate endpoints.ConclusionIn conclusion, there were a number of studies on gastric and liver cancer prevention in developing countries showing promising results after long–term follow–up. Important next steps include pooled meta–analyses as far as possible given the heterogeneity between studies as well as implementation research.

show abstract

“…Cohort studies have also shown mortality reduction by gastric radiographic screening . In Costa Rica also, gastric radiographic screening has been reported to be effective and is recognised as an effective method for reducing the mortality from gastric cancer. However, radiographic screening in that country has been reported to be associated with such problems as low participation rates, and a relatively low availability and aging of physicians with sufficient skills for interpreting gastric radiographs.…”

Section: Discussionmentioning

confidence: 99%