X-ray Structural Studies and Physicochemical Properties of Cimetidine Polymorphism

Structure of ranitidine hydrochloride

“…As part of structural studies of H2-receptor antagonists (Shibata, Kagawa, Morisaka, Ishida & Inoue, 1983;Shibata, Kokubo, Morimoto, Morisaka, Ishida & Inoue, 1983;Ishida, In, Shibata, Doi, Inoue & Yanagisawa, 1987;In, Ishida, Doi, Inoue & Shibata, 1988), the present paper deals with the crystal structure of ranitidine hydrochloride (I). Background intensities were measured for 5 s at each end of a scan.…”

Depth Profiling of Compression-Induced Disorders and Polymorphic Transition on Tablet Surfaces with Grazing Incidence X-ray Diffraction

“…The transition could be polymorphic (12,13), anhydration (14), or amorphization (15). Because the change in the crystal structure of the sample occurs in all these processes, they can be investigated with X-ray diffraction.…”

Structure of N-cyano-N'-methyl-N''-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine (cimetidine) monohydrochloride monohydrate, C10H17N6S+.Cl−.H2O

“…It is utilized in the treatment of peptic ulcer by injection, and has been widely investigated for its stability (Walker et aL, 1981;Yuhas, Loften, Baldinus & Mayron, 1981;Rosenberg, Dougherty, Mayron & Baldinus, 1980). Comparing the four kinds of cimetidine crystalline structures (forms A, B, C and D) with their inhibitory effects for peptic ulceration in rats, we previously proposed that the relative orientation of the cyanoguanidine group with respect to the imidazole ring is an important factor for the effective binding to the histamine H2-receptor (Shibata, Kokubo, Morimoto, Morisaka, Ishida & Inoue, 1983). On the other hand, the conformation of cimetidine may change depending upon the environment, acidic or basic, because it has an imidazole ring capable of being isomerized and shows a weak inhibitory effect of peptic 0108-2701/83/091255-03501.50…”