X-ray Studies of the Closing of the Ductus Arteriosus

Barclay, A. E.; Barcroft, Sir Joseph; Barron, Donald H.; Franklin, K. J.

doi:10.1259/0007-1285-11-129-570

Cited by 22 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, there appears to be little, if any, reliable information as to the approximate time of such closure. Certain obstetricians have told us that they believe the foramen ovale in the human being ceases to be a functional channel at about 6 weeks from birth.When accurate knowledge is deficient to such an extent, any additional evidence, however incomplete, is worthy of note, and we therefore present here certain information that we obtained during our studies of the ductus arteriosus in lambs that were delivered bv Caesarean section [Barclay, Barcroft, Barron & Franklin, 1938].Although the ductus arteriosus became functionally closed within 1 min. from delivery, it was clear that the foramen ovale remained patent for a much longer period.…”

mentioning

confidence: 71%

See 1 more Smart Citation

The time of functional closure of the foramen ovale in the lamb

Barclay¹,

Franklin²

1938

The Journal of Physiology

Self Cite

View full text Add to dashboard Cite

THAT the foramen ovale is open at birth and that it closes shortly after birth are well-known facts. On the other hand, there appears to be little, if any, reliable information as to the approximate time of such closure. Certain obstetricians have told us that they believe the foramen ovale in the human being ceases to be a functional channel at about 6 weeks from birth.When accurate knowledge is deficient to such an extent, any additional evidence, however incomplete, is worthy of note, and we therefore present here certain information that we obtained during our studies of the ductus arteriosus in lambs that were delivered bv Caesarean section [Barclay, Barcroft, Barron & Franklin, 1938].Although the ductus arteriosus became functionally closed within 1 min. from delivery, it was clear that the foramen ovale remained patent for a much longer period. The patency was obvious in our experiments, for, when the radio-opaque medium, thorotrast, was injected into either the superior or the inferior caval system, it passed synchronously to the right and left sides of the heart. We noted such passage in every case, and in one instance it was obvious so late as 6 min. 40 sec. from delivery.Unfortunately, it was only possible to determine the direction of flow, and thereby the patency of the foramen ovale, during the initial injection of thorotrast (unless this was a very small one), for the heart chambers were quickly rendered too opaque for further determination of the direction of flow. In addition, our main object was to ascertain the time of closure of the ductus, and for this the interval between delivery of the lamb and injection of the thorotrast had to be reduced to a minimum.

show abstract

mentioning

confidence: 71%

“…When accurate knowledge is deficient to such an extent, any additional evidence, however incomplete, is worthy of note, and we therefore present here certain information that we obtained during our studies of the ductus arteriosus in lambs that were delivered bv Caesarean section [Barclay, Barcroft, Barron & Franklin, 1938].…”

mentioning

confidence: 90%

The time of functional closure of the foramen ovale in the lamb

Barclay¹,

Franklin²

1938

The Journal of Physiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…This ob servation contradicts the instantaneous closure of the ductus in the lam b postulated by B a r c l a y et <rf. [3 ] from X-ray examinations at caesarean section. However, using an improved X-ray technique.…”

Section: Discussionmentioning

confidence: 99%