X Rays and Radium in the Treatment of Diseases of the Skin

MacKee, George M.

doi:10.1259/are.1922.0124

Cited by 8 publications

(9 citation statements)

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“…Radiation therapy with 250-kVp x-ray beams (orthovoltage radiation therapy) provides a great deal of insight into the effects of radiation on skin (26)(27)(28)(29). The physical dose distribution near the skin surface produced by 250-kVp x-ray beams is not too dissimilar from modern fl uoroscopic beams.…”

Section: Clinical Use Of Radiationmentioning

confidence: 99%

Fluoroscopically Guided Interventional Procedures: A Review of Radiation Effects on Patients’ Skin and Hair

Balter¹,

Hopewell²,

Miller³

et al. 2010

Radiology

508

398

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Most advice currently available with regard to fluoroscopic skin reactions is based on a table published in 1994. Many caveats in that report were not included in later reproductions, and subsequent research has yielded additional insights. This review is a consensus report of current scientific data. Expected skin reactions for an average patient are presented in tabular form as a function of peak skin dose and time after irradiation. The text and table indicate the variability of reactions in different patients. Images of injuries to skin and underlying tissues in patients and animals are provided and are categorized according to the National Cancer Institute skin toxicity scale, offering a basis for describing cutaneous radiation reactions in interventional fluoroscopy and quantifying their clinical severity. For a single procedure performed in most individuals, noticeable skin changes are observed approximately 1 month after a peak skin dose exceeding several grays. The degree of injury to skin and subcutaneous tissue increases with dose. Specialized wound care may be needed when irradiation exceeds 10 Gy. Residual effects from radiation therapy and from previous procedures influence the response of skin and subcutaneous tissues to subsequent procedures. Skin irradiated to a dose higher than 3-5 Gy often looks normal but reacts abnormally when irradiation is repeated. If the same area of skin is likely to be exposed to levels higher than a few grays, the effects of previous irradiation should be included when estimating the expected tissue reaction from the additional procedure.

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Section: Clinical Use Of Radiationmentioning

confidence: 99%

Fluoroscopically Guided Interventional Procedures: A Review of Radiation Effects on Patients’ Skin and Hair

Balter¹,

Hopewell²,

Miller³

et al. 2010

Radiology

508

398

View full text Add to dashboard Cite

show abstract

“…Since no single definitive active ingredient has been found, it is commonly suggested that there may be some synergitic action between the polysaccharide base and other components [1] . According to Mackee [2] , vitamin D was the healing agent, but Row and Parks [3] reported the absence of vitamin D. Morton [4] suggested a theory stating the seeming efficacy of aloe pulp may be attributed to its high water content, i.e., 96%+, providing a means of making water available for injured tissue without sealing it off from the air. This recovery would explain the instant soothing effect of Aloe vera gel has on burns, but would not account for the long term effect of healing.…”

Section: Biological Activity Of Aloe Veramentioning

confidence: 99%

Processing of Aloe Vera Leaf Gel: A Review

Ramachandra¹,

Rao²

2008

American J. of Agricultural and Biological Sciences

165

109

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Proper scientific investigations on Aloe vera have gained more attention over the last decade due to its reputable, medicinal, pharmaceutical and food properties. Some publications have appeared in reputable scientific journals that have made appreciable contributions to the discovery of the functions and utilizations of Aloe vera lacking processing of leaf gel. Present processing techniques aims at producing best quality aloe products but end aloe products contain very little or virtually no active ingredients. Hence, appropriate processing techniques should be employed during processing in order to extend the use of aloe vera gel. Further research needs to be done to unravel the myth surrounding the biological activity and the exploitation of aloe constituents.

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“…Irradiation is, however, not essential to the development of lupus carcinoma since the complication has occurred in cases where X-ray therapy has not been used (Lieberthal, 1911 ;Savatard, 1924), and according to MacKee and Cipollaro (1946) irradiation is only dangerous when pushed to the point of producing X-ray dermatitis. Reference must also be made to the possible carcinogenic effects of carbon-dioxide snow.…”

Section: Discussionmentioning

confidence: 99%

Epithelioma complicating lupus vulgaris necessitating forequarter amputation

Woodruff

Nairn

1954

Journal of British Surgery

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THE development of an epithelioma is a well-recog-ni2e-j complication of lupus vulgaris. T h e treatment of is surgical excision of the epithelioma, the administration of calciferol and antibiotics for the lupus-The operation is usually quite straightforward, but the following case presented unusual difficulties because the primary lesion was extensive treatment. At the age of 21 she sustained a mild blow on the right breast and soon afterwards a patch of lupus developed at the site of injury. This lesion, after ulcer, which was treated by her own doctor with local applicauons of old tuberculin. For the next Seventeen years the patient attended hospital and received various forms of treatment, including applications of pyrogallol, intradermal injections of iodized moogrol, injections of followed if necessary by skin-grafting, together with remaining dry for a year Or a weeping A B C FIG. 594.-A, Axillary lymph-node showing an area of keratinizing epithelioma above and tuberculous lymphadenitis below. 6, High-power view of epitheliomatous area showing cell nests ; four mitotic figures can be seen in the field. H. and E. ( x 24.) ( x 150.) C, High-power view of tuberculous area showing typical tuberculous follicles in lymphoid tissue. x 1 5 0 .and awkwardly situated, and metastases were present in the regional lymph-nodes. The case also had interesting pathological features in that a rapidly growing, metastasizing tumour was combined with a n active tuberculous process, both in the skin and i n the lymph-nodes. CASE REPORTThe patient, a single woman of 49, developed lupus vulgaris on the nose and left cheek when 3 years old. This was treated with tar ointment and a proprietary preparation, Zambuk. Six years later the condition was still active and X-ray therapy was started. There was temporary improvement, but at the age of 11 the lesions on the face began to spread and further lesions appeared on both legs and on the right wrist. Irradiation and local applications were continued for a further three years, after which the patient stopped attending for hydnocarpate, and applications of carbon-dioxide snow. Full details are not available, but according to the patient the applications of snow were given daily for a short time and then at weekly intervals for several years. The condition showed little sign of improvement ; the patient, discouraged, again ceased attending hospital and came under the care of an outside doctor who scarified the lesions and prescribed various ointments. Two years ago, at the age of 47, the dressings on the patient's face accidentally caught fire; the resulting burn led to considerable scarring of the cheeks and an ectropion of the right eyelid. The lupus was not very active at this time, but a year ago the lesions all over the body flared up ; that on the chest, in particular, became very active and the right nipple was gradually eroded.The patient was first seen in the surgical out-patient department in July, 1952. She was then complaining mainly of the chest lesion and of a painful swell...

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X Rays and Radium in the Treatment of Diseases of the Skin

Cited by 8 publications

References 0 publications

Fluoroscopically Guided Interventional Procedures: A Review of Radiation Effects on Patients’ Skin and Hair

Fluoroscopically Guided Interventional Procedures: A Review of Radiation Effects on Patients’ Skin and Hair

Processing of Aloe Vera Leaf Gel: A Review

Epithelioma complicating lupus vulgaris necessitating forequarter amputation

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