X-STRs: Potentials and Applications

Kakkar, Sonia; Kumawat, R. K.; Shrivastava, Pankaj

doi:10.1007/978-981-15-6655-4_15

Cited by 2 publications

(4 citation statements)

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“…neuronal development) [28]. Between the two chromosomes, the utilization of Xchromosome has gained considerable attention in forensic investigation [18], attributable to its special genetic mode of inheritance [19] as a tool of choice in kinship analysis [29]. Female has two X chromosomes which are similar in size and genetic content [27] and each of them is transmitted one from the father and mother, respectively [29,30].…”

Section: Main Body X Chromosome Properties and Mode Of Inheritancementioning

confidence: 99%

“…Between the two chromosomes, the utilization of Xchromosome has gained considerable attention in forensic investigation [18], attributable to its special genetic mode of inheritance [19] as a tool of choice in kinship analysis [29]. Female has two X chromosomes which are similar in size and genetic content [27] and each of them is transmitted one from the father and mother, respectively [29,30]. Gomes and Arroyo-Pardo [31] accentuated that the pair of X chromosomes in a female behaves like the autosomes, whereby they directly recombine with each other during meiosis, and therefore, the mother randomly transmits a recombined X chromosome copy to her daughters and sons.…”

Section: Main Body X Chromosome Properties and Mode Of Inheritancementioning

confidence: 99%

“…With regards to the mode of inheritance, genes that are located at the PAR regions will be in inherited in an autosomal pattern instead of based on sex-linked mode of inheritance and recombined during meiosis [32]. Considering that the X chromosome is transmitted (unchanged) by the father to all his daughters [14], sisters and half-sisters fathered by the same man would have the exact paternal X chromosome (except for mutation) [25,29]. This fact is particularly useful in paternal half-sisters and paternal grandmother or granddaughter relationship investigations [25] as well as explaining clinical genetic diseases [13].…”

Section: Main Body X Chromosome Properties and Mode Of Inheritancementioning

confidence: 99%

“…Progressively, many forensic laboratories are exploring X-STRs analysis on the next-generation sequencing (NGS) or also known as the massive parallel sequencing (MPS), one of the latest technology platforms in DNA profiling [29]. NGS technology has the ability not only to analyze minute quantities of samples (particularly useful for compromised forensic samples) but also to support simultaneous analysis of the different types of markers (e.g.…”

Section: Development Of X-strs Analysismentioning

confidence: 99%

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Applications of X-Chromosome Short Tandem Repeats for Human Identification: A Review

Mahat

Alwi²,

Salleh³

et al. 2023

J.Trop.Life.Science

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The forensic DNA profiling technique has tremendously contributed to forensic human identification, an important aspect in forensic investigations. In instances whereby comparison samples are unavailable, utilization of short tandem repeats of X chromosome (X-STRs) may prove useful to resolve complex kinship investigations involving missing persons and mass disasters. Despite such evidential values, the use of X-STRs during investigations remains scarce in many Southeast Asian countries including Malaysia, requiring concerted efforts for establishing forensic statistical support for its diverse populations (especially the admixture populations), standardizing core loci and procedure, improving the knowledge among practitioners as well as developing suitable standard operating procedure for incorporating X-STRs analysis in the overall DNA profiling framework. Hence, this review paper aims to highlight the developments, applications and population data of X-STRs, as well as its challenges and future insights for forensic casework.

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