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Diagnosis of Essential Hypertension in Humans by the Determination of Plasma Renal Cortexin using Enzyme-Linked Immunosorbent Assay

Ghosh, Rajeshwary; Bhattacharyya, Mau; Khan, Gausal A.; Chakraborty, Somashree; Bhattacharya, Raja; Maji, Uttam Kumar; Jana, Pradipta; Sinha, Asru K.

doi:10.7754/clin.lab.2012.120633

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…1 According to the large epidemiological investigation, patients with essential hypertension (EH) accounted for 90% of patients with hypertension. 2 Although the etiology of EH has not been determined, genetic factors have a certain impact on it. 3,4 In recent years, several studies have indicated that inflammation plays an important role in the development of EH.…”

Section: Introductionmentioning

confidence: 99%

Association between TNF-a promoter -308G/A polymorphism and essential hypertension in the Asian population: A meta-analysis

Yao

Chang

Jin

2017

J Renin Angiotensin Aldosterone Syst

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Objective:The results of studies on the association between tumor necrosis factor-a -308G/A (TNF-a -308G/A) polymorphism, and susceptibility to essential hypertension are controversial. To derive a more precise estimation, we conducted a meta-analysis of all similar articles.Methods:The summary effect odds ratios and 95% confidence intervals were obtained. Funnel plots and Egger’s test were used to estimate publication bias, and heterogeneity was assessed by the chi-square-based Q-test and I2 test.Results:Nine studies (with 1437 cases and 1487 controls) were included. In the overall analysis, the combined results showed that there were significant differences in genotype distribution between essential hypertension cases and controls, AA+GA versus GG (OR = 1.53, 95% CI: 1.25–1.88, p < 0.00001). In the stratified analysis by country, we found that essential hypertension cases had a significantly higher frequency of AA+GA versus GG (OR = 1.47, 95% CI: 1.18–1.81, p = 0.0004) than control in the Asian population.Conclusions:This meta-analysis supports previous findings that TNF-a -308G/A polymorphism may increase the risk of essential hypertension, at least in the Asian population.

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Section: Introductionmentioning

confidence: 99%

Association between TNF-a promoter -308G/A polymorphism and essential hypertension in the Asian population: A meta-analysis

Yao

Chang

Jin

2017

J Renin Angiotensin Aldosterone Syst

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“…Secondary hypertension is a type of hypertension caused by an identifiable underlying secondary cause, such as renovascular disease, renal failure, pheochromocytoma, aldosteronism and others, while essential hypertension is defined as hypertension in which secondary causes are not present (Carretero and Oparil, 2000). More than 90% of all hypertensive persons are reported to have essential hypertension (Ghosh et al , 2013). Essential hypertension is associated with large and small vascular remodeling that impacts cardiovascular prognosis (Briet and Schiffrin, 2013).…”

Section: Introductionmentioning

confidence: 99%

Association of T174M polymorphism of angiotensinogen gene with essential hypertension: a meta-analysis

et al. 2014

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The association between T174M polymorphism of angiotensinogen gene and essential hypertension risk remains controversial. We herein performed a meta-analysis to achieve a reliable estimation of their relationship. All the studies published up to May 2013 on the association between T174M polymorphism and essential hypertension risk were identified by searching the electronic repositories PubMed, MEDLINE and EMBASE, Springer, Elsevier Science Direct, Cochrane Library and Google Scholar. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. Ultimately, nine eligible studies, including 2188 essential hypertension cases and 2459 controls, were enrolled in this meta-analysis. No significant associations were found under the overall ORs for M-allele comparison (M vs. T, pooled OR 0.92, 95% CI 0.62–1.37), MM vs. TT (pooled OR 0.86, 95% CI 0.29–2.51), TM vs. TT n (pooled OR 0.91, 95% CI 0.63–1.32), recessive model (MM vs. TT+TM, pooled OR 0.89, 95% CI 0.35–2.30), dominant model (MM+TM vs. TT, pooled OR 0.91, 95% CI 0.60–1.38) between T174M polymorphism and risk for essential hypertension. This meta-analysis suggested that the T174M polymorphism of the angiotensinogen gene might not be associated with the susceptibility of essential hypertension in Asian or European populations.

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“…Non-human forms of cortexin 3 have species-characteristic tissue distributions but seem to be always enriched in brain. Cortexins 1-3 should not be confused with another “cortexin” (“(r)-cortexin”), a 43 kDa nitric oxide synthase activating protein from kidney, studied mostly in the context of blood pressure regulation and related disorders [ 26 , 27 ]. “Cortexin” may promote growth of neurites [ 28 ] and it has been claimed that it can restore cognition after ischemic stroke [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Association between 5q23.2-located polymorphism of CTXN3 gene (Cortexin 3) and schizophrenia in European-Caucasian males; implications for the aetiology of schizophrenia

Šerý

Lochman

Povová

et al. 2015

Behavioral and Brain Functions

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BackgroundThe objective of the study was to examine several polymorphisms in DISC1 and CTNX3 genes as possible risk factors in schizophrenia. DISC1 (disrupted-in-schizophrenia 1) has been studied extensively in relation to mental disease while CTXN3, has only recently emerged as a potential “candidate” gene in schizophrenia. CTXN3 resides in a genomic region (5q21-34) known to be associated with schizophrenia and encodes a protein cortexin 3 which is highly enriched in brain.MethodsWe used ethnically homogeneous samples of 175 male patients and 184 male control subjects. All patients were interviewed by two similarly qualified psychiatrists. Controls were interviewed by one of the authors (O.S.). Genotyping was performed, following amplification by polymerase chain reaction (PCR), using fragment analysis in a standard commercial setting (Applied Biosystems, USA).ResultsWe have found a statistically significant association between rs6595788 polymorphism of CTXN3 gene and the risk of schizophrenia; the presence of AG genotype increased the risk 1.5-fold. Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.ConclusionEvidence available in the literature suggests that altered expression of cortexin 3, either alone, or in parallel with changes in DISC1, could subtly perturb GABAergic neurotransmission and/or metabolism of amyloid precursor protein (APP) in developing brain, thus potentially exposing the affected individual to an increased risk of schizophrenia later in life.

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Diagnosis of Essential Hypertension in Humans by the Determination of Plasma Renal Cortexin using Enzyme-Linked Immunosorbent Assay

Cited by 6 publications

References 7 publications

Association between TNF-a promoter -308G/A polymorphism and essential hypertension in the Asian population: A meta-analysis

Association between TNF-a promoter -308G/A polymorphism and essential hypertension in the Asian population: A meta-analysis

Association of T174M polymorphism of angiotensinogen gene with essential hypertension: a meta-analysis

Association between 5q23.2-located polymorphism of CTXN3 gene (Cortexin 3) and schizophrenia in European-Caucasian males; implications for the aetiology of schizophrenia

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