2009
DOI: 10.1523/jneurosci.5756-08.2009
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X11-Like Protein Deficiency Is Associated with Impaired Conflict Resolution in Mice

Abstract: Understanding how emotion is generated, how conflicting emotions are regulated, and how emotional states relate to sophisticated behaviors is a crucial challenge in brain research. Model animals showing selective emotion-related phenotypes are highly useful for examining these issues. Here, we describe a novel mouse model that withdraws in approach-avoidance conflicts. X11-like (X11L)/Mint2 is a neuronal adapter protein with multiple protein-protein interaction domains that interacts with several proteins invo… Show more

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Cited by 25 publications
(24 citation statements)
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References 94 publications
(113 reference statements)
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“…β-Gal activity was detected as described previously (Sano et al, 2009). In brief, mice were deeply anesthetized with 2,2,2-tribromoethanol and transcardially perfused with physiologic saline and then 4% PFA in 0.1 M PB, pH 7.4, at 4°C for 20 min.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…β-Gal activity was detected as described previously (Sano et al, 2009). In brief, mice were deeply anesthetized with 2,2,2-tribromoethanol and transcardially perfused with physiologic saline and then 4% PFA in 0.1 M PB, pH 7.4, at 4°C for 20 min.…”
Section: Methodsmentioning
confidence: 99%
“…Monoamines and metabolites were extracted and measured using HPLC with electrochemical detection as described previously (Sano et al, 2009). Acetylcholine was measured using a combination of HPLC, enzymatic reactions, and electrochemical detection (Eicom, Kyoto, Japan), as described previously (Itoh et al, 1999).…”
Section: Methodsmentioning
confidence: 99%
“…145 Recently, Mint2 has been found to play a role in the behavioral neurobiology underlying murine conflict resolution. 146 Mint2 also interacts with a number of other proteins involved with governing cellular properties including Munc-18 and HCN2. 139,144 …”
Section: H Channel Interacting Proteins With As Yet Unknown Functionsmentioning
confidence: 99%
“…Further, X11-KO mice showed alterations in dopaminergic neurotransmission (Mori et al, 2002). X11L and X11L2 single KO mice revealed no obvious deficits, but X11L is functionally redundant for X11, as 80% of X11/X11L DKO mice die early after birth and the surviving mice exhibit increased growth and aggravated motor impairments (Ho et al, 2003, 2006; Sano et al, 2009). Furthermore, mouse X11/X11L mutants exhibited impairments in presynaptic neurotransmitter release, as indicated by lowered basal neurotransmission and reduced miniature excitatory post-synaptic current (mEPSC) frequency (Ho et al, 2006).…”
Section: X11/mint Mutant Micementioning
confidence: 99%