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Hsieh, Yao Yuan; Chang, Chao‐Hsiang; Tsai, Horng‐Der

doi:10.1023/a:1016688806431

Cited by 48 publications

(2 citation statements)

References 18 publications

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“…There is a scientific debate regarding the association of IL-1β and its role in endometriosis. Non-relation has been underlined between endometriosis and the IL-1β −511 promoter, IL-1β exon 5 and IL-1 receptor antagonist genetic variations, since proportions of various polymorphisms did not seem to differ significantly between a group of patients (n=120) and healthy controls (n=103) in a previous study (101). Notably, the association between IL-1β (+3953) polymorphism endometriosis in a Turkish population was assessed as negative, since statistically insignificant proved to be the increased frequency of the respective genotypes (102).…”

Section: Genetic Association Studiesmentioning

confidence: 90%

Defining the genetic profile of endometriosis (Review)

et al. 2019

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Endometriosis is a pathological condition which has been extensively studied, since its pathophysiology stems from a broad spectrum of environmental influences and genetic factors. Familial studies aim at defining inheritance trends, while linkage analysis studies focus on the identification of genetic sites related to endometriosis susceptibility. Genetic association studies take into account candidate genes and single nucleotide polymorphisms, and hence target at unraveling the association between disease severity and genetic variation. The common goal of various types of studies is, through genetic mapping methods, the timely identification of therapeutic strategies for disease symptoms, including pelvic pain and infertility, as well as efficient counselling. While genome-wide association studies (GWAS) play a primary role in depicting genetic contributions to disease development, they entail a certain bias as regards the case-control nature of their design and the reproducibility of the results. Nevertheless, genetic-oriented studies and the implementation of the results through clinical tests, hold a considerable advantage in proper disease management. In this review article, we present information about gene-gene and gene-environment interactions involved in endometriosis and discuss the effectiveness of GWAS in identitying novel potential therapeutic targets in an attempt to develop novel therapeutic strategies for a better management and treatment of patients with endometriosis.

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Section: Genetic Association Studiesmentioning

confidence: 90%

Defining the genetic profile of endometriosis (Review)

et al. 2019

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“…Double cut‐off values of AFC for predicting ovarian reserve were defined as five and ten (bilateral ovaries) based on previous reports. 16 , 17 , 18 Double cut‐off values of AMH levels for predicting ovarian reserve were 1.87 and 5.22 ng/ml according to the thresholds used for diagnosis of infertility at our center. 19 Detailed categorizations were as follows: women with AFC ≤ 5 or AMH ≤ 1.87 ng/ml have poor ovarian reserve; women with 5<AFC<10 or 1.87<AMH<5.22 ng/ml have relatively good ovarian reserve; women with AFC ≥ 10 or AMH ≥ 5.22 ng/ml have good ovarian reserve.…”

Section: Methodsmentioning

confidence: 99%