Xanthan gum-based hydrogel containing nanocapsules for cutaneous diphenyl diselenide delivery in melanoma therapy

Ferreira, Luana Mota; Azambuja, Juliana H.; Silveira, Elita Ferreira da; Cervi, Verônica Ferrari; Marchiori, Marila Crivellaro Lay; Maria‐Engler, Silvya Stuchi; Wink, Márcia Rosângela; Azevedo, Jéssica Gonçalves; Nogueira, Cristina Wayne; Braganhol, Elizandra; Sari, Marcel Henrique Marcondes

doi:10.1007/s10637-019-00823-2

Cited by 40 publications

(22 citation statements)

References 46 publications

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“…Additionally, our data demonstrated that PhSe 2 -loading into nanocapsules increased its scavenger action in comparison to bulk compound, highlighting the improvements achieved by nanoencapsulation. Notably, the obtained IC 50 values for both compound forms were within a concentration range in which no considerable cytotoxic effects were detected in different mammalian cell lines [ 23 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Locust Bean Gum Nano-Based Hydrogel for Vaginal Delivery of Diphenyl Diselenide in the Treatment of Trichomoniasis: Formulation Characterization and In Vitro Biological Evaluation

et al. 2022

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Trichomoniasis is the most common nonviral sexually transmitted infection in the world, but its available therapies present low efficacy and high toxicity. Diphenyl diselenide (PhSe2) is a pharmacologically active organic selenium compound; however, its clinical use is hindered by its lipophilicity and toxicity. Nanocarriers are an interesting approach to overcome the limitations associated with this compound. This study designed and evaluated a vaginal hydrogel containing PhSe2-loaded Eudragit® RS100 and coconut oil nanocapsules for the treatment of trichomoniasis. Nanocapsules presented particle sizes in the nanometric range, positive zeta potential, a compound content close to the theoretical value, and high encapsulation efficiency. The nanoencapsulation maintained the anti-Trichomonas vaginalis action of the compound while improving the scavenger action in a DPPH assay. The hydrogels were prepared by thickening nanocapsule suspensions with locust bean gum (3%). The semisolids maintained the nanometric size of the particles and the PhSe2 content at around the initial concentration (1.0 mg/g). They also displayed non-Newtonian pseudo-plastic behavior and a highly mucoadhesive property. The chorioallantoic membrane method indicated the absence of hemorrhage, coagulation, or lysis. The compound, from both non-encapsulated and nano-based hydrogel delivery systems, remained on the surface of the bovine vaginal mucosa. Therefore, the formulations displayed the intended properties and could be a promising alternative for the treatment of trichomoniasis.

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Section: Discussionmentioning

confidence: 99%

Locust Bean Gum Nano-Based Hydrogel for Vaginal Delivery of Diphenyl Diselenide in the Treatment of Trichomoniasis: Formulation Characterization and In Vitro Biological Evaluation

et al. 2022

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“…The stratum corneum was removed using the tape stripping technique (18 rounds of tape; Scotch 3M ® ). In sequence, the epidermis layer was separated from the dermis by heating the skin fragment in a water bath at 60 °C for 45 s [ 20 , 21 , 22 ]. The sesamol was extracted from the skin layers with a 40% methanolic solution (4 mL for the stratum corneum, 1 mL for the epidermis and 2 mL for the dermis) followed by vortex mixing for 2 min and sonication (Ultrasonic bath Q3.0/40A model, Ultronique, Brazil) for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

et al. 2023

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Irritant contact dermatitis is usually treated with corticosteroids, which cause expressive adverse effects. Sesamol is a phenolic compound with anti-inflammatory and antioxidant properties. This study was designed to evaluate a hydrogel containing sesamol-loaded ethylcellulose nanocapsules for the treatment of irritant contact dermatitis. The nanocapsules presented a size in the nanometric range, a negative zeta potential, a sesamol content close to the theoretical value (1 mg/mL), and a 65% encapsulation efficiency. Nanoencapsulation protected sesamol against UVC-induced degradation and increased the scavenging activity assessed by ABTS and DPPH radicals. The hydrogels were prepared by thickening the nanocapsule suspensions with guar gum (2.5%). The hydrogels maintained the nanometric size of the nanocapsules and a sesamol content of approximately 1 mg/g. The HET-CAM assay classified the hydrogels as nonirritating. The in vitro release of the hydrogel containing sesamol in the nanoencapsulated form demonstrated an initial burst effect followed by a prolonged sesamol release and a lower skin permeation in comparison with the hydrogel containing free sesamol. In addition, it exhibited the best anti-inflammatory effect in the irritant contact dermatitis model induced by croton oil, reducing ear edema and inflammatory cells infiltration, similar to dexamethasone (positive control). Therefore, the hydrogel containing sesamol in the nanoencapsulated form seemed to have a therapeutic potential in treating irritant contact dermatitis.

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“…XG-containing hydrogel nanocapsules (NC (PhSe)2) were developed to deliver cutaneous diphenyl diselenide in resistant melanoma SK-Mel-103 cells. The NC (PhSe)2 showed superior antimelanoma activity as compared to (PhSe)2 alone [135]. Prepared XG-based hydrogels and microspheres released omega-3 polyunsaturated fatty acids in colorectal cells.…”

Section: Paclitaxel (Ptx)-loaded Chitosan Nanoparticles (Nps) Modifie...mentioning

confidence: 99%

Microbial polysaccharides: An emerging family of natural biomaterials for cancer therapy and diagnostics

Prateeksha

Sharma

Liu

et al. 2022

Seminars in Cancer Biology

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Xanthan gum-based hydrogel containing nanocapsules for cutaneous diphenyl diselenide delivery in melanoma therapy

Cited by 40 publications

References 46 publications

Locust Bean Gum Nano-Based Hydrogel for Vaginal Delivery of Diphenyl Diselenide in the Treatment of Trichomoniasis: Formulation Characterization and In Vitro Biological Evaluation

Locust Bean Gum Nano-Based Hydrogel for Vaginal Delivery of Diphenyl Diselenide in the Treatment of Trichomoniasis: Formulation Characterization and In Vitro Biological Evaluation

Development of Guar Gum Hydrogel Containing Sesamol-Loaded Nanocapsules Designed for Irritant Contact Dermatitis Treatment Induced by Croton Oil Application

Microbial polysaccharides: An emerging family of natural biomaterials for cancer therapy and diagnostics

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