Xanthan Gum–Chitosan: Delayed, prolonged, and burst‐release tablets using same components in different ratio

Consumi, Marco; Leone, Gemma; Pepi, Simone; Tamasi, Gabriella; Lamponi, Stefania; Donati, Alessandro; Bonechi, Claudia; Rossi, Claudio; Magnani, Agnese

doi:10.1002/adv.21965

Cited by 10 publications

(12 citation statements)

References 29 publications

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“…Under these conditions, the entry of water will be delayed and the CL kinetics diminished. A similar delay in dissolution profiles was observed in PEC with CS as cationic polymer, with different proportions of xanthan gum or carboxymethyl starch as anionic polymers [ 8 , 33 , 35 ].…”

Section: Resultssupporting

confidence: 56%

“…The Korsmeyer-Peppas kinetic model ( Table 1 ) exhibits anomalous (non-Fickian) dissolution with n values close to 0.86, suggesting that the rate of water uptake into the matrix and CL release were controlled by diffusion through the hydrogel structure and swelling/erosion processes [ 16 ]. The absence of burst effects in the CS/CMC complexes justified the efficient interpenetration of CL within the network [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

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Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

et al. 2021

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This study investigated the combination of different proportions of cationic chitosan and anionic carboxymethyl cellulose (CMC) for the development of polyelectrolyte complexes to be used as a carrier in a sustained-release system. Analysis via scanning electron microscopy (SEM) Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) confirmed ionic interactions occur between the chitosan and carboxymethyl cellulose chains, which increases drug entrapment. The results of the dissolution study in acetate buffer (pH 4.2) showed significant increases in the kinetic profiles of clarithromycin for low proportions of chitosan/carboxymethyl cellulose tablets, while the tablets containing only chitosan had high relaxation of chitosan chains and disintegrated rapidly. The Korsmeyer–Peppas kinetic model for the different interpolymer complexes demonstrated that the clarithromycin transport mechanism was controlled by Fickian diffusion. These results suggest that the matrix tablets with different proportions of chitosan/carboxymethyl cellulose enhanced the ionic interaction and enabled the prolonged release of clarithromycin.

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Section: Resultssupporting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

et al. 2021

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“…As can be seen in Figure 4 , CNM granules achieved the maximum percentage released of MLX at 8 h (88.77 ± 3.46%), yielding more than the reference active ingredient, the pure MLX (78.10 ± 3.01% at the same time), followed by the CFS, with 66.34 ± 2.12% and CNM + CFS with 61.86 ± 2.60% at 8 h. Different studies have shown how the improvement in drug solubility in a pH zone (6.5–7) increases drug solubility at the colon site [ 25 , 46 ]. CNM formulation had the lowest “burst effect”, thus retaining better MLX for possible enteral use.…”

Section: Resultsmentioning

confidence: 99%

Multiparticulate Systems of Meloxicam for Colonic Administration in Cancer or Autoimmune Diseases

et al. 2022

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The aim of this research is the development of new colonic release systems of meloxicam (MLX) a non-steroidal anti-inflammatory drug (NSAIDs) with pH and time-dependent vehicles for cancer or autoimmune diseases. The colon has a higher pH than the rest of the gastrointestinal tract (GIT) and this can be used as a modified release strategy. Eudragit® polymers are the most widely used synthetic products in the design of colonic release formulations because they might offer mucoadhesiveness and pH-dependent release. Colonic delivery systems produced with pH-dependent and permeable polymers (FS-30D) or with pH-independent and low permeability polymers (NM-30D), must dissolve at a pH range of 6.0–7.0 to delay the release of the drug and prevent degradation in the GIT, before reaching the colon. The conditions prepared to simulate a gastrointestinal transit showed the CNM multiparticulate system, composed of Eudragit® NM and cellulose, as the best release option for MLX with a more sustained release with respect to the other formulations. CNM formulation followed Higuchi and First-order release kinetics, thus MLX release was controlled by a combination of diffusion and polymers swelling/eroding processes.

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“…MM, in which melting point is at 36–42 °C [ 29 ], is the major component of NLC and nanobeads. In addition, two endothermic peaks, related to the biopolymers’ dehydration for CHT at 144.4 °C [ 30 ] and for XAN at 115.0 °C [ 15 ], were noticed.…”

Section: Resultsmentioning

confidence: 99%

Hybrid Nanobeads for Oral Indomethacin Delivery

et al. 2022

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The oral administration of the anti-inflammatory indomethacin (INDO) causes severe gastrointestinal side effects, which are intensified in chronic inflammatory conditions when a continuous treatment is mandatory. The development of hybrid delivery systems associates the benefits of different (nano) carriers in a single system, designed to improve the efficacy and/or minimize the toxicity of drugs. This work describes the preparation of hybrid nanobeads composed of nanostructured lipid carriers (NLC) loading INDO (2%; w/v) and chitosan, coated by xanthan. NLC formulations were monitored in a long-term stability study (25 °C). After one year, they showed suitable physicochemical properties (size < 250 nm, polydispersity < 0.2, zeta potential of −30 mV and spherical morphology) and an INDO encapsulation efficiency of 99%. The hybrid (lipid-biopolymers) nanobeads exhibited excellent compatibility between the biomaterials, as revealed by structural and thermodynamic properties, monodisperse size distribution, desirable in vitro water uptake and prolonged in vitro INDO release (26 h). The in vivo safety of hybrid nanobeads was confirmed by the chicken embryo (CE) toxicity test, considering the embryos viability, weights of CE and annexes and changes in the biochemical markers. The results point out a safe gastro-resistant pharmaceutical form for further efficacy assays.

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Xanthan Gum–Chitosan: Delayed, prolonged, and burst‐release tablets using same components in different ratio

Cited by 10 publications

References 29 publications

Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets

Multiparticulate Systems of Meloxicam for Colonic Administration in Cancer or Autoimmune Diseases

Hybrid Nanobeads for Oral Indomethacin Delivery

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