Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing

Abstract

Hydrogels are considered to be the most ideal materials for the production of wound dressings since they display a three-dimensional structure that mimics the native extracellular matrix of skin as well as a high-water content, which confers a moist environment at the wound site. Until now, different polymers have been used, alone or blended, for the production of hydrogels aimed for this biomedical application. From the best of our knowledge, the application of a xanthan gum–konjac glucomannan blend has not been used for the production of wound dressings. Herein, a thermo-reversible hydrogel composed of xanthan gum–konjac glucomannan (at different concentrations (1% and 2% w/v) and ratios (50/50 and 60/40)) was produced and characterized. The obtained data emphasize the excellent physicochemical and biological properties of the produced hydrogels, which are suitable for their future application as wound dressings.

Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers

“…In the present research, biocomposite biopolymeric microfibers were fabricated using alginate, gelatin, xanthan gum, and nanoclay. The microfibers were prepared employing the ionotropic gelation method, and xanthan gum [ 11 , 12 ] and nanoclay [ 13 , 14 ] were additionally used to enhance the mechanical strength of the fibers. Furthermore, physicochemical, physico-mechanical, and morphological analyses were also executed.…”

Hydrogel Dressings for the Treatment of Burn Wounds: An Up-To-Date Overview

“…The development of a suitable material for covering the wound and further prevent infection is a long-established requirement [82]. Researchers have been using different natural polymers, such as alginate [81,[83][84][85], chitosan [81,[86][87][88], collagen [89,90], dextran [91,92], hyaluronan [2,93], xanthan [94,95], konjac [95], and gelatin [96] for the production of hydrogels. Their wide application in wound dressing fabrication is based on their similitude to the extracellular matrix (ECM), which further improves acceptance by biological systems through the inhibition of the immunological reactions frequently observed for synthetic polymers [81,97].…”

“…The bioactive compound improved the antibacterial activity of the gels by maintaining the physiological environment for wound healing and preventing bacteria growth on the surface of the wound. Alves et al [95] obtained a thermo-reversible hydrogel comprising of xanthan gum and konjac glucomannan (Figure 5) at different concentrations and ratios. The obtained hydrogels showed a transparent and moisturized appearance (Figure 6), which permitted the continuous observation of the wound healing process without dressing removal.…”

“…The obtained hydrogels showed a transparent and moisturized appearance (Figure 6), which permitted the continuous observation of the wound healing process without dressing removal. The obtained hydrogels are hydrophilic, thus providing a moist environment, while also absorbing the excess exudate and suitable biological properties for promoting cell adhesion, migration, and proliferation [95].…”

Physicochemical and biological characterization of a xanthan gum-polyvinylpyrrolidone hydrogel obtained by gamma irradiation

“…Among the materials with potential for hydrogels© synthesis, polymers of natural origin such as xanthan gum (XG) and synthetic origin such as polyvinylpyrrolidone (PVP) are included. XG is a natural polymer obtained by the fermentation of carbohydrates by bacteria of the genus Xanthomonas (17), it is biocompatible, hydrophilic and promotes cell adhesion, proliferation, and cell migration (18), furthermore is also suitable for modified drug release (19). In contrast, PVP is a synthetic polymer that has also shown potential application in the synthesis of hydrogels due to its biocompatibility, low toxicity, and the ability to generate porous structures (20,21).…”