Xanthates: Metabolism by Flavoprotein-Containing Monooxygenases and Antimycobacterial Activity

Yanev, S.; Stoyanova, Tsveta; Valcheva, Violeta; Montellano, Paul R. Ortiz de

doi:10.1124/dmd.118.081984

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…This review is dedicated to Prof. Paul Ortiz de Montellano, whose research has had a tremendous impact in numerous fields, one of which is the study of prodrug bioactivation by monooxygenases [1][2][3]. Prodrugs are chemically modified versions of an active molecule that must undergo transformation to release the functional product, typically implicating one or more enzyme catalysts.…”

Section: Preface and Coenzyme A Biosynthesismentioning

confidence: 99%

The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation

Duncan

Auclair

2019

Archives of Biochemistry and Biophysics

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Prodrugs account for more than 5% of pharmaceuticals approved worldwide. Over the past decades several prodrug design strategies have been firmly established; however, only a few functional groups remain amenable to this approach. The aim of this overview is to highlight the use of coenzyme A (CoA) biosynthetic enzymes as a recently explored bioactivation scheme and provide information about its scope of utility. This emerging tool is likely to have a strong impact on future medicinal and biological studies as it offers promiscuity, orthogonal selectivity, and the capability of assembling exceptionally large molecules.

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Section: Preface and Coenzyme A Biosynthesismentioning

confidence: 99%

The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation

Duncan

Auclair

2019

Archives of Biochemistry and Biophysics

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Physico-chemical studies of some 3d-metal chelates of potassium propan-1,3-diol di xanthate

Kumar¹,

Kumar²

2019

AJSS

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The present study include the synthesis of potassium propan-1,3-diol di xanthate (PPDDX) along with the preparation of Mn (II), Fe (II and III), Co (II), Ni (II) and Cu (II) chelates of PPDDX. The 1:1 stoichiometry of these chelates is decided with the help of electrometric and chemical analysis. All the complexes are found paramagnetic in nature. The stereo-chemistry and the nature of hybridisation of these chelates are also decided in the present study. All these complexes are found to have high spin octahedral geometry except Cu-complex which is square planar in nature. Excluding Cu-complex all others are found to be sp 3 d 2 in nature but Cu-complex has dsp 2 hybridisation. Metal-sulphur bonding in these complexes is established with the help of infrared spectroscopy.

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Xanthates: Metabolism by Flavoprotein-Containing Monooxygenases and Antimycobacterial Activity

Cited by 2 publications

References 24 publications

The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation

The coenzyme A biosynthetic pathway: A new tool for prodrug bioactivation

Physico-chemical studies of some 3d-metal chelates of potassium propan-1,3-diol di xanthate

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