Xanthene derived potent nonpeptidic inhibitors of recombinant human calpain I

Solvent Free, One Pot Synthesis of Symmetric Xanthene Dyes and Their Electrochemical Study

“…In a 250 ml round bottom flask a well mixed mixture of 0.308 gm (0.001mol) of 4,4′-oxydiphthalic anhydride (1) and substituted phenols (2a-e Scheme 1) 0.004 mol were taken and fused in oil bath at 180 o C. The fused melt was added 0.2 g of NH 4 Cl , and stirred the reaction mixture mechanically at 180-190 o C until the solid mass obtained. The solid mass was dissolved in 10 ml of 5 % sodium hydroxide solution.…”

“…Xanthene dyes are extremely important class of dyes because of their wide range of biological and pharmaceutical properties, such as agricultural bactericide activity 1 , anti-inflammatory and anti viral 2 , antioxidant 3 , anticancer 4 , cytotoxic 5 and antiproliferative properties 6 . These are being utilized as antagonists for paralyzing action of zoxazolamine 7 and in photodynamic therapy 8,9 .…”

Efficient one-pot synthesis of 14-aryl-14H-dibenzo[a,j]xanthene derivatives promoted by niobium pentachloride

“…The synthesis of xanthenes and their derivatives has received significant attention due to their various pharmacological activities, such as antibacterial and antifungal (Limsuwan et al, 2009;Omolo et al, 2011), analgesic and anti-inflammatory (Hafez et al, 2008;Banerjee et al, 2011), anti-viral (Jamison et al, 1990Naidu et al, 2012), antioxidant (Nishiyama et al, 1998), anti-cancer (Chatterjee et al, 1996;Song et al, 2013), cytotoxic (Bhattacharya et al, 2009) and antiproliferative properties (Kumar et al, 2010). These compounds have also been employed as sensitisers in photodynamic therapy (Neckers, 1989;Gutiérrez & García, 1998;Chang et al, 2008), in the food industry as additives (Tanaka, 2001;Chequer et al, 2012;Odo et al, 2012;Qi et al, 2012), in laser technologies (Ahmad et al, 2002;De et al, 2005) and as fluorescent materials for the visualisation of biomolecules (Knight & Stephens, 1989;Liu et al, 2001;Hilderbrand & Weissleder, 2007).…”

CuO-CeO2 Nanocomposite: An Efficient Recyclable Catalyst for the Synthesis of Aryl-14H-dibenzo[a-j]xanthenes

“…The catalytic activity of CuO-CeO 2 nanocomposite is well known for the oxidation of CO in H 2 -rich streams [9]. Xanthene derivatives are important class of compounds that received significant attention from many pharmaceutical and organic chemists because of the broad spectrum of their biological and pharmaceutical properties such as antibacterial [10], anti-inflammatory [11], and antivirial properties [12]. Furthermore, these compounds are used as dyes and fluorescent material for visualization of biomolecules and in laser technologies due to their useful spectroscopic properties [13,14].…”