Xanthine oxidase and nitric oxide inhibitory activities of compounds isolated from Gomphrena celosioides

Abstract

In this study, the investigation of xanthine oxidase and nitric oxide formation inhibitory activities of three compounds isolated from aerial part of Gomphrena celosioides, a folk medicinal plant for treatment of gout disease, is reported. The isolated compounds were determined based on NMR and ESI‐MS spectra, they are umbellatosides B, 20‐hydroxyecdysone, and 20‐hydroxyecdysone‐20,22‐monoacetonide. Biological activity results indicated that three compounds showed great activities, in which, umbellatosides B has good activity with IC50 value of 33.78 ± 0.49 and 19.55 ± 0.61 µm for xanthine oxidase and nitric oxide inhibitory activities, respectively. This is the report on the xanthine oxidase and nitric oxide inhibitory activities of three compounds that were first time isolated from the G. celosioides.