Xanthogranulomatous cholecystitis mimicking gallbladder cancer

Ewelukwa, Ofor; Ali, Omair; Akram, Salma

doi:10.1136/bcr-2013-200530

Cited by 7 publications

(9 citation statements)

References 27 publications

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“…Histopathological examination is the best way to make the diagnosis with high accuracy. As in our case, it shows lipid-laden macrophages in the background of chronic inflammatory cells and fibroblasts [3,4]. Cholecystectomy is the definitive management of choice.…”

Section: Discussionsupporting

confidence: 68%

Xanthogranulomatous Cholecystitis: A Rare Variant of Chronic Cholecystitis

Alammari¹,

Alhessan²,

Alturki³

et al. 2022

Cureus

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Gallbladder disease is a very common condition that encompasses a heterogeneous group of diseases with a wide range of severity and clinical manifestations. Gallbladder disorders include biliary colic, acute cholecystitis, chronic cholecystitis, choledocholithiasis, Mirizzi syndrome, and gallstone ileus. We report the case of a 70-year-old man who presented to the emergency department complaining of worsening abdominal pain, located in the right upper quadrant and radiating to the right shoulder. It was aggravated by food intake and relieved with the use of antacid medications. The medical history of the patient was significant for stable angina, hypertension, diabetes mellitus, hyperlipidemia, and sickle cell trait. Examination of the abdomen revealed generalized tenderness with guarding. Abdominal computed tomography scan demonstrated the presence of significant diffuse thickening of the gallbladder wall with poor contrast enhancement. Complete resection of the gallbladder was performed because of suspected gallbladder carcinoma. Histopathological examination revealed xanthogranulomatous cholecystitis, which is a rare form of chronic cholecystitis. The differentiation between gallbladder carcinoma and xanthogranulomatous cholecystitis may not be easy and histopathological examination is the most accurate way to make the diagnosis.

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Section: Discussionsupporting

confidence: 68%

Xanthogranulomatous Cholecystitis: A Rare Variant of Chronic Cholecystitis

Alammari¹,

Alhessan²,

Alturki³

et al. 2022

Cureus

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“…This inflammatory process of a xanthogranulomatous reaction is a rare pathological finding; however, it has been described in many organ systems including the gallbladder, kidneys, and ovaries. This reaction causes a diffusely destructive process that can be compared to chronic cholecystitis in the gallbladder but mimicking gallbladder carcinoma [8]. Xanthogranulomatous pyelonephritis, also diagnosed by histology, has also shown similar features to that of renal cell carcinoma [9].…”

Section: Discussionmentioning

confidence: 99%

Xanthogranulomatous Breast Mass: An Unusual Presentation

Zahid¹,

Kummarapurugu²,

Alrefai³

2021

Cureus

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Xanthogranulomatous inflammatory reactions are benign inflammatoryprocesses characterized by aggregating lipid-laden foamy macrophages.Although cases have been reported in different organ systems, these rare reactions predominantly occur in the kidney and gallbladder. We present a 92-year-old female who noticed a palpable, tender mass in the lower inner quadrant of her right breast with no skin changes. She was referred to surgery by her primary care physician on suspicion of malignancy and further evaluation. Ultrasound-guidedbiopsy, ordered by the primary care provider, revealed a suspicious high-grade malignant neoplasm of uncertain origin. Pathological findings include the presence of an unusual population of malignant epithelioid cells with astriking xanthogranulomatous reaction, along with numerous Touton-like histiocytes. These findings are comparable in morphology to a recently reportedxanthogranulomatous epithelial tumor. Given the lack of history of breast carcinomain this patient as well as the lack of immunohistochemical studies suggesting breast carcinoma, treatment involved continuing standard of care for an unusual high-grade sarcoma via lumpectomy. A positron emission tomography (PET) scan was ordered to ensure there was no spread or alternate origins of the cancer tissue. This case report brings to light the findings of a probable xanthogranulomatous tumor in breast tissue, an exceptionally rare phenomenon in breastcancer, especially in the elderly population. Due to the rarity of xanthogranulomatous tumors in the breast, prognosis and standardized treatment haveyet to be established.

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“…Few articles have been published describing the similarities and differences between XGC from gallbladder cancer[ 5 6 ] and few reports about false-positive results on FDG-PET/CT scan. [ 7 ] Several studies have shown the strong association between gallstones and XGC,[ 8 ] as seen in our case.…”

Section: Discussionmentioning

confidence: 99%