Xanthogranulomatous cholecystitis presenting with duodenal ulcer and cholecystoenteric fistula

Fu, Chih-Yuan; Hsieh, Tsai‐Yuan; Chan, De‐Chuan; Lee, H. S.; Huang, Tsai-Wang

doi:10.1055/s-0032-1309359

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…The percentage of biliary fistula/gallbladder perforation was significantly higher ( p = 0.045) in XGC patients than in GBC patients, which is consistent with other reports. 3 , 8 , 9 , 10 Also, GBC patients presented a significantly higher percentage of chronic infection exposure ( p < 0.001). Few statistical differences were encountered in jaundice, perforation and abscess formation, hyperlipidemia, and diabetes between these XGC patients and GBC patients.…”

Section: Resultsmentioning

confidence: 93%

“…XGC patients usually share similar symptoms with cholecystitis patients, and their imaging characteristics also present a certain degree of similarity with gallbladder carcinoma (GBC) patients’. 1 , 2 , 3 It is often difficult to differentiate GBC from XGC, and the severe proliferative fibrosis surrounding the gallbladder might cause more confusion. The definitive diagnosis depends on pathologic examination after the performance of cholecystectomy and fine‐needle aspiration.…”

Section: Introductionmentioning

confidence: 99%

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Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients

et al. 2021

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Background: Xanthogranulomatous cholecystitis (XGC) is an extremely rare entity. Due to XGC's clinical and radiological resemblance to gallbladder carcinoma (GBC), intraoperative frozen section during cholecystectomy is often performed to exclude the diagnosis of GBC. Our study is aiming to find a noninvasive indicator of XGC. To our knowledge, this is the largest XGC cohort ever studied.Methods: This study retrospectively collected clinical characteristics, serological tests, and imaging features of 150 GBC patients and 90 XGC patients. The diagnosis of these 150 GBC patients and 90 XGC patients was based on intraoperative frozen section histopathology. T-test was utilized to compare differences between XGC and GBC. Receiver operating characteristic (ROC) curve was conducted and the area under the curve (AUC) was managed to evaluate the validity. Results:The carcinoembryonic antigen (CEA) level in blood tests was significantly elevated in GBC patients than in XGC patients (p = 0.007). The presence of submucosal hypo-attenuated nodules (80% in XGC, 16% in GBC, p < 0.001), low density border (60% in XGC, 21% in GBC, p = 0.001), and nodular thickening in the bottom of the gallbladder with calcification (70% in XGC, 37% in GBC, p = 0.004) is significantly associated with XGC patients, whereas massive hilar infiltration (0% in XGC, 21% in GBC, p < 0.001), multiple lymph nodes in the hilar area (10% in XGC, 72% in GBC, p = 0.001), and gallbladder mucosal line continuity (50% in XGC, 95% in GBC, p = 0.002) are highly associated with GBC patients. The ROC curve was performed and the gallbladder mucosal line continuity (AUC = 0.708) and the AUC of low density border around the occupation (AUC = 0.654) showed a good prediction of XGC.Conclusions: Gallbladder mucosal line continuity and low density border around the occupation presented good indication value for the diagnosis of XGC.Our study proposed a noninvasive differential diagnosis method for XGC and GBC.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients

et al. 2021

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“…Dietary cholesterol might play a role in cancer development via changes in lipid metabolism, which are related to cellular inflammation [10]. An increase in total cholesterol and low-density lipoprotein (LDL) as well as a decrease in high-density lipoprotein (HDL) could induce the production of inflammatory biomarkers, such as interleukin-6 and tumor necrosis factor-a [11].…”

Section: Dietary Fats and Cholesterolmentioning

confidence: 99%

Diet and carcinogenesis of gastric cancer

Maddineni

Xie

Brahmbhatt

et al. 2022

Current Opinion in Gastroenterology

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Purpose of reviewSeveral recent studies have corroborated a strong association between diet and gastric cancer risk; investigators have also identified dietary factors that protect against gastric cancer. This review summarizes the literature on this topic and guides future research directions.Recent findingsHigh-salt intake disrupts the gastric mucosal defense barrier, promoting Helicobacter pylori colonization and penetration of other carcinogenic compounds. Processed foods, processed meats, red meat, alcohol, foods with high dietary fat, and dietary cholesterol increase the risk of gastric carcinogenesis. On the other hand, increased consumption of fruits, vegetables, whole grains, nuts, and a low-salt diet may offer a protective effect.SummaryDespite decreases in gastric cancer incidence because of increased identification and treatment of H. pylori, gastric cancer remains one of the most common cancers worldwide with a high mortality rate. This disturbing statistic highlights the importance of reducing and eliminating other risk factors for gastric cancer. There is a strong body of evidence that alcohol, processed foods, high salt intake, high fat intake, and foods with animal products (meats, eggs, and dairy) increase the risk of gastric cancer. A diet that is high in whole grains, fruits, vegetables, nuts and is low in salt may reduce the risk of gastric cancer.

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Spectrum of Xanthogranulomatous Processes in the Abdomen and Pelvis: A Pictorial Review of Infectious, Inflammatory, and Proliferative Responses

Bourm

Menias

Ali

et al. 2017

American Journal of Roentgenology

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Xanthogranulomatous cholecystitis presenting with duodenal ulcer and cholecystoenteric fistula

Cited by 4 publications

References 4 publications

Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients

Noninvasive preoperative differential diagnosis of gallbladder carcinoma and xanthogranulomatous cholecystitis: A retrospective cohort study of 240 patients

Diet and carcinogenesis of gastric cancer

Spectrum of Xanthogranulomatous Processes in the Abdomen and Pelvis: A Pictorial Review of Infectious, Inflammatory, and Proliferative Responses

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