Xanthogranulomatous endometritis: case report

Barua, Ranadhir; Kirkland, James A.; Petrucco, O. M.

doi:10.3109/00313027809063496

Cited by 29 publications

(35 citation statements)

References 3 publications

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“…Although xanthogranulomatous inflammation is a distinguishing histopathological entity affecting various organs (chiefly the kidney and gall bladder), xanthogranulomatous endometritis is very uncommon [3–6]. The first case of XGE was described by Barua et al [6] in 1978.…”

Section: Discussionmentioning

confidence: 99%

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Histiocytic endometritis

Vhawal

2013

Am J Case Rep

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Patient: Female, 72Final Diagnosis: Histiocytic endometritisSymptoms: Vaginal discharge • fever • weaknessMedication: —Clinical Procedure: Endometrial and cervical biopsySpecialty: Pathology • GynaecologyObjective:Rare diseaseBackground:Histiocytic or xanthogranulomatous endometritis, characterized by disappearance of endometrial mucosa and its replacement by sheets of lipid containing histiocytic cells, is very rare. Extensive internet and PubMed searches revealed only 19 cases reported to date. The pathogenesis of histiocytic endometritis seems to be inflammation due to post-menopausal cervical stenosis or as the result of cervical carcinoma. Histiocytic endometritis can infiltrate the myometrium and can mimic a malignancy.Case Report:We report the case of a 78-year-old post-menopausal female with symptoms of vaginal discharge, fever, and weakness. Radiological investigation showed a mass lesion in the cervix, extending into the myometrium, suggestive of cervical carcinoma. The lesion was biopsied and histopathological examination led to the diagnosis of histiocytic endometritis with no evidence of malignancy.Conclusions:Histiocytic endometritis, an inflammatory pathology, can mimic malignancy clinically as well as radiologically. Histopathological examination with extensive sampling of tissue is essential because presence of endometritis does not rule out malignancy.

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Section: Discussionmentioning

confidence: 99%

“…The first case of XGE was described by Barua et al [6] in 1978. Subsequent authors have added a few cases (Table 1): Buckley and Fox [7] in 1980 (2 cases), Ashkenazy et al [5] in 1983 (4 cases), and Pounder and Iyer [3] in 1985 (1 case).…”

Section: Discussionmentioning

confidence: 99%

Histiocytic endometritis

Vhawal

2013

Am J Case Rep

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“…Among others, infectious agents Escherichia coli , Proteus vulgaris , Enterococcus spp. and Proteus magnus have been described [8]. However, these micropathogens do not typically play an etiological role in PID.…”

Section: Discussionmentioning

confidence: 99%

Extensive chronic xanthogranulomatous intra-abdominal inflammation due to Mycoplasma hominis mimicking a malignancy: a case report

et al. 2009

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IntroductionWhile infectious peritonitis is a common occurrence in patients with liver cirrhosis, Mycoplasma is rarely identified as a causative agent.Case presentationWe report the case of a 43-year-old Caucasian woman presenting with an extensive abdominal conglomerate tumor mimicking malignancy. A histologic specimen showed a xanthogranulomatous inflammation. Subsequently, Mycoplasma hominis was identified as the specific causative infectious agent using a broad-range (eubacterial) polymerase chain reaction. To the best of our knowledge, this is the first reported case of an intra-abdominal Mycoplasma infection presenting as a conglomerate tumor.ConclusionAn unusual presentation of an inflammatory process in the abdomen or an insufficient response to conventional therapy should prompt clinicians to consider atypical infectious agents in the differential diagnosis. This case illustrates the potential of newer diagnostic methods, since certain fastidious microorganisms may not be diagnosed and treated appropriately using conventional means.

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“…Kunakemakorn was the first to report inflammatory pseudotumor in the pelvis in 1976 1. To date, only 13 cases of xanthogranulomatous inflammation in the ovary and fallopian tubes 1-10, and 15 cases in the endometrium have been reported in the English literature 11-15. In this paper we report three cases of xanthogranulomatous inflammation in the female genital tract with review of the literature on this subject.…”

Section: Introductionmentioning

confidence: 86%

Xanthogranulomatous Inflammation of the Female Genital Tract: Report of Three Cases

Zhang¹,

Dong²,

Zhang³

et al. 2012

J. Cancer

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Purpose and Methods: This is a series of three cases diagnosed with xanthogranulomatous inflammation of the female genital with emphasis on the etiology, clinical-pathologic features and biological behavior. Clinical, pathologic, radiologic and follow up data are reported.Results: The three cases of Xanthogranulomatous inflammation of the female genital tract are the followings: 1) one case affecting the endometrium, 2) one case affecting the fallopian tube, and 3) one case confined to the ovary. The patient's age was 37, 22 and 62 year-old, respectively. Histologic examination revealed extensive infiltration of foamy histiocytes admixed with variable amount of inflammatory cells. The later include plasma cells, lymphocytes, and occasional multinucleated giant cells. Immunohistochemistry showed positive staining for CD68, a histiocytic marker, in foamy histiocytes, CD3, a T cell marker, and CD20, a B cell marker, in the background lymphocytes. The plasma cells were polyclonal with expression of both κ and λ light chains.Conclusion: Xanthogranulomatous inflammation of the female genital tract is an unusual lesion, and clinically forms mass- like lesion in the pelvic cavity that invades the surrounding tissues, which may mimic the tumor clinically and by imaging.

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Xanthogranulomatous endometritis: case report

Cited by 29 publications

References 3 publications

Histiocytic endometritis

Histiocytic endometritis

Extensive chronic xanthogranulomatous intra-abdominal inflammation due to Mycoplasma hominis mimicking a malignancy: a case report

Xanthogranulomatous Inflammation of the Female Genital Tract: Report of Three Cases

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