Xanthogranulomatous gastritis with pseudosarcomatous changes

Abstract. A case of xanthogranulomatous inflammation of the small bowel in a 12-year-old male American Staffordshire Terrier is described. Disseminated yellow-white nodules 2 to 3 mm in diameter bulging on the serosal surface of the small bowel, as well as on mesenteric tissue, were detected. Histopathologic examination revealed a nodular collection of foamy cells, mainly involving serosal and muscular layers, associated with necrotic areas, hemorrhages, neovascularization, variable numbers of reactive spindle cells, neutrophils, lymphocytes, plasma cells, and rare multinucleated giant cells. Transmural lymphangectasia and mucosal lymphoplasmacytic inflammation were also observed. Both Oil Red O stain and ultrastructural study revealed lipid droplets in the cytoplasm of foamy cells. Lysozyme immunoreactivity was detected in single as well as in clustered foamy cells, while smooth muscle actin was positive in spindle cells and scattered foamy elements. Lymphangectasia associated with lymphoplasmacytic enteritis suggests a component of lymphatic fluid stasis in the pathogenesis of such lesions.

show abstract

“…colon, 13,16 stomach, 11 and parotid gland. 3 To the best of our knowledge, such process has not yet been described in veterinary literature.…”

mentioning

confidence: 99%

Xanthogranulomatous Inflammation of the Small Bowel in a Dog

et al. 2008

View full text Add to dashboard Cite

show abstract

“…However, rare cases of xanthogranulomatous inflammation have additionally been reported in other organs, including the stomach, colon, pancreas and uterus (3-6). The occurrence of xanthogranuloma of the stomach is rare, and only a few cases have been reported to date (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). To the best of our knowledge, this is the first reported case of xanthogranulomatous gastritis in the remnant stomach.…”

Section: Discussionmentioning

confidence: 99%

“…Preoperative diagnosis of xanthogranulomatous inflammation is difficult and its' features are unknown (1)(2)(3)(4)(5)(6). A xanthogranuloma occurring in the stomach is rare, and to the best of our knowledge, only a few cases have been reported to date (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). In such cases, the disease was preoperatively misdiagnosed as a submucosal tumor or advanced gastric cancer, and gastrectomy was performed (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Xanthogranulomatous gastritis of the remnant stomach mimicking a malignant tumor: A case report

et al. 2015

View full text Add to dashboard Cite

Abstract. Xanthogranulomas are known to develop in the gallbladder and kidney. Xanthogranuloma of the stomach is a rare disease, and to the best of our knowledge, only a few cases have been reported to date. The present patient was a 64-year-old man who underwent a wide resection of the stomach following a Billroth-I reconstruction for a gastric ulcer ~40 years prior to the current presentation. Due to tarry stools, a gastrointestinal endoscopy was performed, leading to identification of an ulcerated gastric lesion located at the previous suture line at the lesser curvature of the remnant stomach. This lesion was elevated, appearing to indicate a submucosal tumor. Positron emission tomography revealed uptake of fluorodeoxyglucose radiotracer by the tumor. Although not indicated by the biopsy specimens, a malignant tumor of the remnant stomach was suspected, in the form of a malignant gastrointestinal tumor or remnant gastric cancer. Curative resection of the tumor was successfully performed. Histological examination of the resected specimens revealed xanthogranulomatous inflammation consisting of foamy histiocytes and plasma cells, however, no cancer cells were observed. The tumor was diagnosed as xanthogranulomatous gastritis that mimicked a malignant tumor of the remnant stomach. The present study therefore indicates that inflammatory tumors should be considered in the differential diagnosis of malignant tumors.

show abstract

“…Microscopic examination of XGI usually reveals a nodular or diffuse collection of foamy histiocytes, intermixed with varying amounts of other inflammatory cells, such as multinucleated giant cells, lymphocytes, plasma cells, and eosinophils, as well as fibrosis. Occasionally, cholesterol clefts, granulation tissue, and necrotic debris are observed with reactive lymphoid hyperplasia 4 . The pathogenesis of GIXGI is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Xanthogranulomatous inflammatory reaction associated with endoscopic mucosal resections of gastric and colonic cancer

Hwang¹,

Lee²,

Park³

et al. 2011

Basic and Applied Pathology

View full text Add to dashboard Cite

Background and aim: Xanthogranulomatous inflammatory reaction (XGI) is a rare diagnosis in the gastrointestinal tract. It could be misinterpreted as an invasive cancerous lesion. The pathogenesis of XGI in the gastrointestinal tract (GIXGI) is not well understood. We clinicopathologically studied six cases of GIXGI associated with endoscopic biopsy, mucosal resection, and submucosal dissection of gastric and colonic adenocarcinoma. Methods: Immunohistochemical, special histochemical stains, and tuberculosis‐polymerase chain reaction (PCR) were performed. All radiological images and medical records of the patients were reviewed. Results: All cases showed XGI with foamy histiocytes, lymphocytes, and foreign body‐type giant cells, which were positive for CD68 and negative for CD117, S‐100, and cytokeratin. Acid‐fast, Gomori's methenamine silver, periodic acid Schiff stains, and nontuberculous Mycobacterium and Mycobacterium tuberculosis‐PCR were also negative. Two of four gastric adenocarcinomas were suspected to be advanced gastric cancer by computed tomography staging. However, the microscopic examination revealed only XGI with a mucosal carcinoma or without any residual tumor cells in the gastric wall. Conclusions: GIXGI may simulate advanced carcinoma clinicoradiologically. GIXGI should be included in the differential diagnosis in the case suggestive of a rapid transition to advanced gastrointestinal carcinoma within 12 weeks from the preoperative endoscopic procedure.

show abstract

Xanthogranulomatous gastritis with pseudosarcomatous changes

Cited by 21 publications

References 12 publications

Xanthogranulomatous Inflammation of the Small Bowel in a Dog

Xanthogranulomatous Inflammation of the Small Bowel in a Dog

Xanthogranulomatous gastritis of the remnant stomach mimicking a malignant tumor: A case report

Xanthogranulomatous inflammatory reaction associated with endoscopic mucosal resections of gastric and colonic cancer

Contact Info

Product

Resources

About