Xanthogranulomatous pyelonephritis: a review and meta-analysis with a focus on management

Gravestock, Paul; Moore, Lauren; Harding, Chris; Veeratterapillay, Rajan

doi:10.1007/s11255-022-03253-x

Cited by 7 publications

(2 citation statements)

References 46 publications

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“…The differential diagnosis of XGP includes malignancy and tuberculosis. The usual management is nephrectomy, whereas antimicrobial therapy has only a secondary role ( 10 , 11 ). In this case report, because making a definitive diagnosis by CT was difficult, nephrectomy was performed to confirm the presence of macrophage-charged lipids in inflamed areas.…”

Section: Discussionmentioning

confidence: 99%

Systemic Amyloid A Amyloidosis Secondary to Xanthogranulomatous Pyelonephritis

Habuka,

Nishikiori,

Oikawa

et al. 2024

Intern. Med.

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The combination of systemic amyloid A (AA) amyloidosis and xanthogranulomatous pyelonephritis (XGP) resulting from a chronic urinary tract infection is extremely rare. We herein report a case of systemic AA amyloidosis secondary to XGP for which clinical remission developed after nephrectomy. To our knowledge, this is the first case report describing the clinical improvement of systemic AA amyloidosis secondary to XGP after nephrectomy in Japan. Clinicians should be aware of this uncommon combination and search for amyloid depositions in cases of XGP.

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Section: Discussionmentioning

confidence: 99%

Systemic Amyloid A Amyloidosis Secondary to Xanthogranulomatous Pyelonephritis

Habuka,

Nishikiori,

Oikawa

et al. 2024

Intern. Med.

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“…It was first described in 1916 by Schlagenhaufer and this condition occurs in approximately 1% of all kidney infections [4,5].…”

Section: Introductionmentioning

confidence: 99%

Septic shock secondary to xanthogranulomatous pyelonephritis: A case report and literature review

Lopez Jaime,

Alonso Morales,

Perzabal Avilez

et al. 2024

J Case Rep Images Urol

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Introduction: Xanthogranulomatous pyelonephritis is described by histopathology as a destruction of the renal parenchyma and replaced by a chronic infiltrate of lipid-laden macrophages. It is known that patients with xanthogranulomatous pyelonephritis have a high rate of perioperative and postoperative morbimortality; however, there are few case reports on this entity. Case Report: A 35-year-old woman attended the emergency department due to the presence of pain in the left flank, accompanied by an altered state of consciousness and respiratory distress. The study protocol started, identifying a significant increase in the left kidney, the presence of a central staghorn stone, dilated minor calices, and clinically with septic shock. The clinical conditions improved by adding intravenous fluids, vasoactive amines, red blood cells concentrates, and broad-spectrum antibiotics. Subsequently, a left nephrectomy was performed. On the following days, the septic shock gradually resolved, leading to the patient’s discharge. Eventually, histopathology report was reviewed, confirming a xanthogranulomatous pyelonephritis. Conclusion: When a xanthogranulomatous pyelonephritis clinical suspicion is found, it is considered a surgical emergency. Furthermore, if proper management is not given immediately, there is a high risk of complications and death. However, the current statistics in Mexico have not been updated to contrast these data.

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