Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis

Cho, Young-Chang; You, Sung-Kyun; Kim, Hyun Jung; Cho, Cheong-Weon; Lee, Ik‐Soo; Kang, Bok Yun

doi:10.1016/j.intimp.2010.02.002

Cited by 43 publications

(40 citation statements)

References 45 publications

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“…Recent data showing decreased cholesterol concentrations in atherosclerotic plaques of XN‐treated mice expressing human CE transfer protein support our findings. XN has been considered an anti‐inflammatory substance according to findings in various in vitro and in vivo studies . We observed decreased MCP‐1 but not significantly reduced IL‐6 serum concentrations.…”

Section: Discussionmentioning

confidence: 45%

“…XN also lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats . Decreased production of the proinflammatory cytokines IL‐1 beta, inducible nitric oxide synthase , and IL‐12 in LPS‐activated macrophages, and reduced monocyte chemoattractant protein 1 (MCP‐1) and tumor necrosis factor alpha concentrations were observed after XN treatment in mouse macrophages and human monocytes . These beneficial effects of XN on inflammation, obesity, and hyperlipidemia as important risk factors for cardiovascular disease prompted us to study the effects of XN on atherosclerosis development in ApoE‐deficient ( ApoE −/− ; where ApoE is apoliprotein E) mice, which develop severe hypercholesterolemia and atherosclerosis in the aorta and coronary arteries .…”

Section: Introductionmentioning

confidence: 99%

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Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE‐deficient mice

Doddapattar

Radović

Patankar

et al. 2013

Molecular Nutrition Food Res

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Scope: Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and glucose metabolism. Based on its favorable biological properties, we investigated whether XN attenuates atherosclerosis in western-type diet-fed apolipoprotein-E-deficient (ApoE −/− ) mice. Methods and results: XN supplementation markedly reduced plasma cholesterol concentrations, decreased atherosclerotic lesion area, and attenuated plasma concentrations of the proinflammatory cytokine monocyte chemoattractant protein 1. Decreased hepatic triglyceride and cholesterol content, activation of AMP-activated protein kinase, phosphorylation and inactivation of acetyl-CoA carboxylase, and reduced expression levels of mature sterol regulatory element-binding protein (SREBP)-2 and SREBP-1c mRNA indicate reduced lipogenesis in the liver of XN-fed ApoE −/− mice. Concomitant induction of hepatic mRNA expression of carnitine palmitoyltransferase-1a in ApoE −/− mice-administered XN suggests increased fatty acid betaoxidation. Fecal cholesterol concentrations were also markedly increased in XN-fed ApoE −/− mice compared with mice fed western-type diet alone. Conclusion: The atheroprotective effects of XN might be attributed to combined beneficial effects on plasma cholesterol and monocyte chemoattractant protein 1 concentrations and hepatic lipid metabolism via activation of AMP-activated protein kinase.

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Section: Discussionmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE‐deficient mice

Doddapattar

Radović

Patankar

et al. 2013

Molecular Nutrition Food Res

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“…In our study, flavanones, chromanones, and chalcones having hydroxyl groups did not show any insect antifeedant activity. The most inactive was a 4-hydroxychalcone (11), which was an attractant. An additional substituent of a hydroxyl group at the para position in ring B of a chalcone decreased the antifeedant activity, compared to the unsubstituted chalcone (10).…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Insect Antifeedant Potential of Xanthohumol, Isoxanthohumol, and Their Derivatives

Stompor

Dancewicz

Anioł

2015

J. Agric. Food Chem.

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Xanthohumol (14) and isoxanthohumol (6) derived from hop (Humulus lupulus L., Cannabaceae) and selected chalcone and chromene derivatives, obtained by chemical synthesis, were studied for antifeedant activity against the peach-potato aphid (Myzus persicae [Sulz.]). The study used also commercially available 4-chromanone (1), flavanone (4), naringenin (5), chromone (7), flavone (8), 7-aminoflavone (9), trans-chalcone (10), and 4-methoxychalcone (12). For chromone derivatives it was observed that the presence of a phenyl substituent at C-2 in the chromone (7) skeleton increased the insect antifeedant activity, and this activity was observed for a longer time. Also, the introduction of an amino group at C-7 of flavone (8) considerably increased the insect antifeedant activity, which was observed for the whole test time. Among the compounds examined, the strongest deterrents were isoxanthohumol (6), 7-methoxy-2,2-dimethylchroman-4-one (3), 7-aminoflavone (9), and 4-ethyl-4'-methoxychalcone (13).

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“…Toxicity of 8-Prenylnaringenin was also evaluated by Tokalov et al [31] with the resazurin-based assay. 8PN had no significant inhibitory effect for human promyeloid leukemia cell line (HL-60) and breast cancer cell line (MCF-7) up to 50 µM concentration after 24 hour incubation, but MCF-7 cells were clearly more 6 resistant. This is in accordance with results of our experiment.…”

Section: Cytotoxicity Of Naringenin and 8-prenylnaringeninmentioning

confidence: 96%

“…Xanthohumol, the most important chalcone, which amounts up to 1% of the hop-cone dry weight, has many biological properties. Apart from strong antioxidant activity, it was proved to have antiviral [4], antimicrobial [5] and anti-inflammatory action [6]. Moreover, in vitro study proved that xanthohumol inhibits formation of new blood vessels during carcinogenesis and it has antiproliferative properties against human cancer cell lines: breast (MCF-6, MCF-7, T47-D), colon (HT-29), ovarian (A-2780) and prostate ones [7 -12].…”

mentioning

confidence: 99%

In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells—Cellular Accumulation and Cytotoxicity

Stompor¹,

Uram²

2017

Preprint

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Gliomas are one of the most aggressive and treatment-resistant types of human cancer. One of the most promising field in gliomas cancer therapy is identification and evaluation of anticancer properties of compounds found in plants i.a. naringenin (N) and 8-prenylnaringenin (8PN). The prenyl group seem to be crucial to the anticancer activity of flavones, which may lead to enhanced cell membrane targeting and thus increased intracellular activity. Unfortunately, 8PN content in hop cones is from 10 to 100 times lower compared to other flavonoids i.e. xanthohumol. In this study we used a simple method for the synthesis of 8PN from isoxanthohumol, via O-demethylation with high, 97% of the isolated yield. Cellular accumulation and cytotoxicity of naringenin and 8-prenylnaringenin in normal (BJ) and cancer cells (U-118 MG) were also examined. Obtained data indicated that 8-prenylnaringenin exhibited higher toxicity against used cell lines than naringenin and both flavones inhibited stronger glioblastoma U-118 MG cells than normal fibroblasts. The anticancer properties of 8PN correlated with its significantly greater (37%), accumulation in glioblastoma cells than in normal fibroblasts. Additionally, naringenin indicated higher selectivity for glioblastoma as it was over 6 times more toxic for cancer than normal cells. Our results provide evidence that examined prenylated and non-prenylated flavanones have different biological activity against normal and cancer cell lines and this phenomenon may be useful in clinical practice to construct new, anticancer drugs for glioblastoma.

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Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis

Cited by 43 publications

References 45 publications

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE‐deficient mice

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE‐deficient mice

Insect Antifeedant Potential of Xanthohumol, Isoxanthohumol, and Their Derivatives

In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells—Cellular Accumulation and Cytotoxicity

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Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis

Cited by 43 publications

References 45 publications

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE‐deficient mice

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE‐deficient mice

Insect Antifeedant Potential of Xanthohumol, Isoxanthohumol, and Their Derivatives

In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells&mdash;Cellular Accumulation and Cytotoxicity

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In Vitro Effect of 8-Prenylnaringenin and Naringenin on Fibroblasts and Glioblastoma Cells—Cellular Accumulation and Cytotoxicity