Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3β pathway

Zhu, Laiyu; Fan, Xinli; Cao, Chunyuan; Li, Kailiang; Hou, Wei; Ci, Xinxin

doi:10.1016/j.biopha.2023.115097

Cited by 12 publications

(2 citation statements)

References 35 publications

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“…These effects agree with previous evidence, highlighting that the HOP extract was able to increase the GSH levels, thus likely counteracting the intracellular oxidative stress [26]. Previous evidence also highlighted that some key compounds detected in the ECP and HOP extracts, such as chicoric acid, xanthohumol, hydroxytyrosol, thymol and isoquercetin, act as Nrf2 modulators [79,[114][115][116][117][118].…”

Section: Discussionsupporting

confidence: 90%

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

Percaccio,

De Angelis,

Acquaviva

et al. 2023

Nutrients

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Respiratory viral infections continue to pose significant challenges, particularly for more susceptible and immunocompromised individuals. Nutraceutical strategies have been proposed as promising strategies to mitigate their impact and improve public health. In the present study, we developed a mixture of two hydroalcoholic extracts from the aerial parts of Echinacea purpurea (L.) Moench (ECP) and the cones of Humulus lupulus L. (HOP) that can be harnessed in the prevention and treatment of viral respiratory diseases. The ECP/HOP mixture (named ECHOPvir) was characterized for the antioxidant and cytoprotective properties in airway cells. Moreover, the immunomodulating properties of the mixture in murine macrophages against antioxidant and inflammatory stimuli and its antiviral efficacy against the PR8/H1N1 influenza virus were assayed. The modulation of the Nrf2 was also investigated as a mechanistic hypothesis. The ECP/HOP mixture showed a promising multitarget bioactivity profile, with combined cytoprotective, antioxidant, immunomodulating and antiviral activities, likely due to the peculiar phytocomplexes of both ECP and HOP, and often potentiated the effect of the single extracts. The Nrf2 activation seemed to trigger these cytoprotective properties and suggest a possible usefulness in counteracting the damage caused by different stressors, including viral infection. Further studies may strengthen the interest in this product and underpin its future nutraceutical applications.

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Section: Discussionsupporting

confidence: 90%

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

Percaccio,

De Angelis,

Acquaviva

et al. 2023

Nutrients

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“…The overexpression of PRKAA1 decreased P62 and SIRT2 protein levels and enhanced P-PRKAA1, Beclin1, and LC3B-II levels in TAA-induced mice and AML12 cells. Previous studies have reported that enhancement of AMPK/glycogen synthase kinase-3β (GSK3β)/Nuclear factor-erythroid 2-related factor 2 (Nrf2) signalling pathway protects against APAP-induced ALF 33 , 34 .…”

Section: Discussionmentioning

confidence: 99%

The SIRT2-AMPK axis regulates autophagy induced by acute liver failure

Zhang,

Guo,

Shi

et al. 2024

Sci Rep

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This study explores the role of SIRT2 in regulating autophagy and its interaction with AMPK in the context of acute liver failure (ALF). This study investigated the effects of SIRT2 and AMPK on autophagy in ALF mice and TAA-induced AML12 cells. The results revealed that the liver tissue in ALF model group had a lot of inflammatory cell infiltration and hepatocytes necrosis, which were reduced by SIRT2 inhibitor AGK2. In comparison to normal group, the level of SIRT2, P62, MDA, TOS in TAA group were significantly increased, which were decreased in AGK2 treatment. Compared with normal group, the expression of P-PRKAA1, Becilin1 and LC3B-II was decreased in TAA group. However, AGK2 enhanced the expression of P-PRKAA1, Becilin1 and LC3B-II in model group. Overexpression of SIRT2 in AML12 cell resulted in decreased P-PRKAA1, Becilin1 and LC3B-II level, enhanced the level of SIRT2, P62, MDA, TOS. Overexpression of PRKAA1 in AML12 cell resulted in decreased SIRT2, TOS and MDA level and triggered more autophagy. In conclusion, the data suggested the link between AMPK and SIRT2, and reveals the important role of AMPK and SIRT2 in autophagy on acute liver failure.

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Plant-Derived Nrf2 Activators to Enhance Liver Antioxidative and Regenerative Potentials

Tee,

Kee,

Chai

et al. 2024

Rev. Bras. Farmacogn.

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Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3β pathway

Cited by 12 publications

References 35 publications

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

ECHOPvir: A Mixture of Echinacea and Hop Extracts Endowed with Cytoprotective, Immunomodulatory and Antiviral Properties

The SIRT2-AMPK axis regulates autophagy induced by acute liver failure

Plant-Derived Nrf2 Activators to Enhance Liver Antioxidative and Regenerative Potentials

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