Xanthoma of Bone: A Mini Review

Ahmed, Ghalib; Salameh, Motasem; AbuHejleh, Hasan

doi:10.4172/2471-2671.1000130

Cited by 5 publications

(11 citation statements)

References 17 publications

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“…[18] The usual reported age of bone xanthoma is after the second decade with male predominance. [1] The same demographic distribution has been observed in spinal intraosseous xanthomas reported so far. Regarding systemic associations, hyperlipidemia and cutaneous xanthoma were found in 69% and 53% of patients of bone xanthomas, respectively.…”

Section: Discussionsupporting

confidence: 71%

“…As evident, the term "secondary" means occurring in the setting of endocrine or metabolic diseases with increased cholesterol levels, or a preexisting bony lesion, whereas the term "primary" is reserved for cases with no preexisting lesion as well as normal lipid profile. [1] However, it has been reported that bone xanthoma can precede the onset of hyperlipidemia as long as 15 years and can be the first sign of dyslipidemia. [18] The usual reported age of bone xanthoma is after the second decade with male predominance.…”

Section: Discussionmentioning

confidence: 99%

“…No recurrences have been reported in the literature following appropriate treatment. [1] Our patient was treated with near-total excision of the tumor with C5 corpectomy using standard anterior approach with bone grafting and plate fixation. Postoperatively, the patient had a significant improvement in spasticity and power in all four limbs.…”

Section: Discussionmentioning

confidence: 99%

“…Bone xanthoma is a known entity with predilection for the appendicular skeleton, but involvement of the axial skeleton is also well mentioned in the literature. [ 1 ] The spine is an atypical site for xanthoma and can be divided into osseous, extradural, intradural, and intramedullary types. [ 2 3 4 5 6 7 8 ] Intraosseous involvement is rare, and only six cases have been reported in the adult population.…”

Section: Introductionmentioning

confidence: 99%

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Primary intraosseous xanthogranuloma in adult cervical spine: A case report of benign cause of lytic bone lesion

et al. 2021

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Lytic lesions in adult spine are a common manifestation of aggressive disease such as primary bone tumor, metastasis, myeloma, or infectious pathology. Xanthoma arising in the spine with purely intraosseous component is an extremely rare occurrence with only six cases reported in the adult population, none in the cervical region. We report the first case of primary xanthoma of the cervical spine in a 50-year-old male solely confined to osseous compartment. The imaging mimics of lytic lesion with expansile mass in adult spine are reiterated.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary intraosseous xanthogranuloma in adult cervical spine: A case report of benign cause of lytic bone lesion

et al. 2021

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“…Most xanthomas occur in the setting of multiple endocrine or metabolic disorders, such as hyperlipidemia, diabetes, hypothyroidism, and lipoprotein lipase de ciency [2]. However, they have also been reported in non-hyperlipidemic conditions [1,3].…”

Section: Introductionmentioning

confidence: 99%

Xanthoma of the Bone Mimicking Malignant Bone Tumor with Secondary Aneurysmal-Cystic Change: A Case Report

Yang

Yeh

Wan

et al. 2023

Preprint

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Background Xanthomas are commonly found in the soft tissues of hyperlipidemic patients. Rarely, they may involve the skeletal system, with various radiographic appearances, mimicking bone malignancies. Case presentation: A 55-year-old woman presented with back pain and bilateral lower limb weakness for several months. After serial imaging studies, multifocal osteolytic lesions were identified in the pelvis and spine, with the largest measuring 94 mm in diameter. An abnormal lipid profile and typical cutaneous presentation aided in the final pathological diagnosis of bone xanthoma. Conclusions Xanthoma of the bone may be confused with aggressive bone lesions radiologically. Clinical, laboratory, and physical findings, in addition to pathological features, are required to make an accurate diagnosis.

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