Xanthomatized Atypical T Cells in a Patient With Mycosis Fungoides and Hyperlipidemia

Abstract

In mycosis fungoides, malignant T cells may be intimately involved in processing of tissue lipids. We suggest that low-density lipoprotein receptors on activated T cells facilitated the cytoplasmic lipidization in this case.

Treatment of Mycosis Fungoides with Bexarotene Results in Remission of Diffuse Plane Xanthomas

“…Association of plane xanthomas with CTCL has rarely been reported in the medical literature. [4][5][6][7][8] Pathogenesis has been suggested to be associated with lipoprotein leakage in MF plaques and subsequent histiocyte phagocytosis, leading to plane xanthoma formulation close to the tumor plaques. 4 Plane xanthomas in normolipidemic patients with MF might be produced because of alteration in lipoprotein content or structure, local tissue alteration (trauma, inflammation, local tissue synthesis), or lymphoproliferative disease.…”

Blastic Plasmacytoid Dendritic Cell Neoplasm Associated with Dystrophic Xanthomatosis after Chemotherapy

“…Lipids are probably released from neoplastic cells after local tissue hypermetabolism or damage following therapy, and therefore engulfed by macrophages (7). In addition, it has been hypothesized that a release of intracytoplasmic cytokines, such as interleukin-4 (8), could directly activate the histiocytic response and, in rare instances, malignant cells may play a direct role in lipoprotein processing and xanthomatization (9).…”