Xanthomonas maltophilia Endophthalmitis After Implantation of Sustained-release Ganciclovir

Stenotrophomonas maltophilia Induced Post-Cataract-Surgery Endophthalmitis: Outbreak Investigation and Clinical Courses of 26 Patients

“…Some of the microorganisms that cause it (such as S. maltophilia), show intrinsic resistance to many currently used antibiotics and therefore constitute a special challenge. There are only few reported cases of iatrogenic S. maltophilia-induced endophthalmitis in the literature [5][6][7][8][9][10]. Here we report the largest outbreak of S. maltophilia-induced PE published so far, describing a cluster of 26 patients who were infected within two days at a single hospital due to contaminated rinsing solution.…”

“…All 26 patients were given topical and systemic antibiotic treatment in addition to intravitreal antibiotics, which were adapted based on the results of antibiotic susceptibility testing after identifying S. maltophilia. A final visual acuity of ‡ 0.2 was achieved by 21 of 26 patients (80%), as compared to 56% of patients with Gram-negative microorganisms cultured from eye samples in the EVS [17] and 56% overall in the S. maltophilia PE cases reported in previous case reports [5][6][7][8][9][10]. A final visual acuity of ‡ 0.5 was achieved by 14 of 26 patients (54%) compared to 50% of patients with Gram-negative PE in the EVS and 37.5% in previous S. maltophilia PE case reports.…”

“…The EVS [15] concluded that intravenous antibiotics were not helpful, but these findings were questioned because the drugs dispensed in the EVS, i.e., ceftazidime and amikacin, were considered poor choices for the suspected causative agents [18,19]. In the cases of iatrogenic S. maltophilia PE reported in the literature so far [5][6][7][8][9][10], some authors have given systemic antibiotics as part of the initial treatment regimen [6,9], while other authors have initiated systemic antibiotics only with clinical deterioration of the infection, usually after the detection of the causative pathogen [5,8,10]. One author abstained from systemic antibiotics [7].…”

“…S. maltophilia, which expresses intrinsic high-level resistance to many currently used antibiotics, can cause infections of any part of the body [4]. While ocular infections such as keratitis or conjunctivitis are known in conjunction with S. maltophilia, there have been only a few reported cases of iatrogenic S. maltophilia-induced endophthalmitis since its first description in 1960 [5][6][7][8][9][10].…”

Co‐existence of Staphylococcus spp and Stenotrophomonas maltophilia infection in persistent endophthalmitis after cataract surgery

“…13 Our patient was immunocompetent with no significant medical history. She developed inflammation on the first day after surgery.…”