Xanthotoxol alleviates secondary brain injury after intracerebral hemorrhage by inhibiting microglia-mediated neuroinflammation and oxidative stress

Metabolite profiling, antioxidant and anti-glycemic activities of Tartary buckwheat processed by solid-state fermentation(SSF)with Ganoderma lucidum

“…Particularly, 14 ketone compounds such as kaempferol 7-cellobioside 3-sophoroside, luteolin-7-O-glucoside and hesperetin were significantly down-regulated, probably because they were converted to other substances under different microorganisms and fermentation conditions or used as growth energy by fungi during the fermentation ( Xiao, Yang, et al, 2021 ). Many increased compounds mentioned in the present research, such as kaempferol, hesperidin, quercetin 3-O-malonylglucoside and xanthohumol, are well proven to exert potent antioxidant and anti-diabetes effects ( Choi, Lee, & Lee, 2022 ; Katsube et al, 2006 ; Zhang et al, 2023 ; Zhu et al, 2023 ). Therefore, many phenolic and flavonid compounds enhanced during SSF may be one of the reasons for the increased antioxidant activity of buckwheat.…”

E3 ligase Nedd4L promotes macrophage M1 polarization and exacerbates brain damage by TRAF3/TBK1 signaling pathway after ICH in mice

“…Numerous evidence from preclinical and clincal studies demonstrated that neuroin ammatory response contributed to the pathogenesis of secondary brain injury following ICH (21)(22)(23). Neuroin ammation in CNS is a complex process, which initiated by different groups of glial cells.…”