Xantoastrocitoma pleomórfico espinal: Caso clínico

Simal-Julián, Juan Antonio; Sanchis-Martín, Rosa; Prat-Acín, Ricardo; Miranda-Lloret, Pablo; Conde-Sardón, Rebeca; Cárdenas-Ruiz-Valdepeñas, Eugenio; Beltrán-Giner, Andrés

doi:10.4321/s1130-14732010000500004

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…[ 11 17 19 ] However, rare lesions have been reported in the cerebellum, cerebellopontine angle (CPA), spinal cord, hypothalamus, sella, and retina, as well as occurring multifocally. [ 1 3 7 13 14 15 21 22 24 25 29 30 31 36 38 39 ] Only three cases of histologically confirmed PXA in the pineal gland have been reported, of which two were benign,[ 33 34 ] and one featured anaplastic elements. [ 18 ] Notably, four cases of PXA-like tumors have been reported in the pineal gland, including PGCAs[ 28 32 ] and an atypical pleomorphic astrocytoma.…”

Section: Discussionmentioning

confidence: 99%

Atypical pleomorphic neoplasms of the pineal gland: Case report and review of the literature

et al. 2015

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Background:Pineal region tumors are rare and diverse. Among them exist reports of pleomorphic xanthroastrocytoma (PXA) and pleomorphic granular cell astrocytoma (PGCA) of the pineal gland. These related tumors are remarkably similar sharing pleomorphic histologic features with only minor immunohistochemical and ultrastructural differences.Case Description:We present a case of a 42-year old right-handed woman presented with a longstanding history of migraine headaches which had worsened over the two months leading up to her hospitalization. MRI revealed a 1.7 × 1.3 × 1.6 cm intensely enhancing lesion originating in the pineal gland. The tumor closely resembled PGCA but did not strictly fit the diagnostic requirements of either PGCA or PXA.Conclusion:The present case highlights the exotic nature of pineal region tumors with pleomorphic cell histology. Given the diverse range of tumors encountered in the pineal region, pathological confirmation is mandatory. Favorable clinical outcomes demonstrate that surgical resection alone can yield excellent long-term results for tumors falling within the spectrum of pleomorphic lesions of the pineal gland.

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Section: Discussionmentioning

confidence: 99%

Atypical pleomorphic neoplasms of the pineal gland: Case report and review of the literature

et al. 2015

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Demography, Pattern of Care, and Survival in Patients with Xanthoastrocytoma: A Systematic Review and Individual Patient Data Analysis of 325 Cases

Mallick

Giridhar

Benson

et al. 2019

Journal of Neurosciences in Rural Practice

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Objectives Xanthoastrocytoma (XA) is a low-grade glial tumor seen in young adults and there is lack of robust data on treatment of this rare tumor. In this systematic review and individual patient's data analysis, we aimed to look into the demography, pattern of care, survival outcomes, and prognostic factors in patients with both Grade II and III XA. Methods A comprehensive search was conducted with the Medical Subject Heading terms: “Xanthoastrocytoma; Pleomorphic Xanthoastrocytoma; Anaplastic Xanthoastrocytoma; Xanthoastrocytoma AND treatment; and Anaplastic Xanthoastrocytoma AND survival” to find all possible publications. Results A total of 325 individual patients from a total of 138 publications pertaining to XA were retrieved. Median age of the entire cohort was 19 years. About 56.1% of the patients underwent a gross total resection (GTR) and 31.4% underwent a subtotal resection. Nearly, 76.6% of the patients had a Grade II tumor and adjuvant radiation was delivered in 27.4% of the patients. Estimated 2- and 5-year progression-free survival (PFS) were 68.5 and 51.2%, respectively. Age, grade, and extent of surgery were significant factors affecting PFS. Estimated 2- and 5-year overall survival (OS) was 88.8 and 78%, respectively. The median OS for Grade II and Grade III tumors were 209 and 49 months, respectively. Age and extent of surgery were significant factors affecting OS. Conclusion XA is a disease of young adults with favorable prognosis. Younger patients (<20 years), patients who undergo a GTR, and patients with a lower grade tumor have a better treatment outcome.

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Intradural extramedullary pleomorphic xanthoastrocytoma: A case report

Klinger

Dillon

Clement

et al. 2020

Surgical Neurology International

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Background: Pleomorphic xanthoastrocytomas (PXAs) are uncommon intradural and typically intramedullary astrocytic central nervous system tumors. Although they commonly occur supratentorially, they are rarely seen in the spine. Case Description: A 43-year-old male presented with cervical neck pain and right-sided radicular symptoms. He was found to have an intradural extramedullary mass at the C5–C6 level. The lesion was fully excised and proved to be a PXA. Of interest, the lesion did not recur on postoperative MR imaging studies obtained 7 months later. Conclusion: While rare, primary intradural extramedullary spinal PXA has been reported. Here, we review such a lesion occurring in a 43-year-old male who did well following gross total excision of the tumor.

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Xantoastrocitoma pleomórfico espinal: Caso clínico

Cited by 3 publications

References 15 publications

Atypical pleomorphic neoplasms of the pineal gland: Case report and review of the literature

Atypical pleomorphic neoplasms of the pineal gland: Case report and review of the literature

Demography, Pattern of Care, and Survival in Patients with Xanthoastrocytoma: A Systematic Review and Individual Patient Data Analysis of 325 Cases

Intradural extramedullary pleomorphic xanthoastrocytoma: A case report

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