XBB.1.5: A new threatening SARS-CoV-2 Omicron subvariant

Functionalized Fullerene Potentially Inhibits SARS-CoV-2 Infection by Modulating Spike Protein Conformational Changes

“…The NTD and RBD of wild-type variant (WT) consisted of residues 14-526 in chain A of the SARS-CoV-2 spike protein (PDB code: 6VXX) [23]; since several fragments were not resolved in these Cryo-EM structures, SWISS-MODEL [24][25][26] was employed to replenish the missing atoms. Next, we constructed the 3D structure of NTD and RBD (residues 14-525) of XBB.1.5 [27] using Alphafold2 Colab [28,29]. The sequences of WT 1-526 and XBB 1-525 are shown in Figure 10b.…”

A review of SARS-CoV-2 variants and vaccines: Viral properties, mutations, vaccine efficacy, and safety

“…Positive SARS-CoV-2 patients displayed a notable feature of medical manifestations that appeared 2–14 days after infection [4] , [5] , [6] , [7] , [8] . The common COVID-19 symptoms are fever, cough, chill, difficulties in breathing, fatigue, body aches, and headache are most common [5] , [6] , [9] .…”

“…Positive SARS-CoV-2 patients displayed a notable feature of medical manifestations that appeared 2–14 days after infection [4] , [5] , [6] , [7] , [8] . The common COVID-19 symptoms are fever, cough, chill, difficulties in breathing, fatigue, body aches, and headache are most common [5] , [6] , [9] . Several techniques are available to detect SARS-CoV-2, where the gold standard and mostly used technique is reverse transcription polymerase chain reaction (RT-PCR) to identify genetic markers [10] , [11] .…”

“…The Delta and Omicron variants and their sub-lineages pose an even more than other variants [8] . WHO declared variant B.1.1.529 as a VOC, which was named Omicron on November 26 2021 [6] , [7] . These variants have caused widespread concern and alarm, resulting in the imposition of stricter lockdown measures and travel restrictions globally [10] , [16] .…”

XBB.1.16: A new ultimatum for global public health

“…The RT-PCR test is the most popular kind of NAAT utilized globally 7 . SARS-CoV-2 antigen can be detected more rapidly on nasal swabs than most NAATs 8 . Nasopharyngeal, nasal, nasal mid-turbinate swabs, and nasal or nasopharyngeal wash/aspirate can be used as specimens for both NAATs and Antigen tests.…”