XBP1-FoxO1 interaction regulates ER stress-induced autophagy in auditory cells

Kishino, Akiyoshi; Hayashi, Ken; Hidai, Chiaki; Masuda, Takeshi; Nomura, Yasuyuki; Oshima, Takeshi

doi:10.1038/s41598-017-02960-1

Cited by 64 publications

(54 citation statements)

References 80 publications

(66 reference statements)

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“…FOXO1 has been reported to act as a tumor suppressor for MM (76). The activation of FOXO1 could subsequently inhibit the tumor growth and induce cell autophagy and cell death (77)(78)(79)(80). FOXO3, another family member of the FOXO family, has been studied in MM (81).…”

Section: Discussionmentioning

confidence: 99%

A predicted risk score based on the expression of 16 autophagy‑related genes for multiple myeloma survival

Zhu¹,

Wang

Zeng³

et al. 2019

Oncol Lett

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Autophagy has an important role in the pathogenesis of plasma cell development and multiple myeloma (MM); however, the prognostic role of autophagy-related genes (ARGs) in MM remains undefined. In the present study, the expression profiles of 234 ARGs were obtained from a Gene Expression Omnibus dataset (accession GSE24080), which contains 559 samples of patients with MM analyzed with 54,675 probes. Univariate Cox regression analysis identified 55 ARGs that were significantly associated with event-free survival of MM. Furthermore, a risk score with 16 survival-associated ARGs was developed using multivariate Cox regression analysis, including ATIC,

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Section: Discussionmentioning

confidence: 99%

A predicted risk score based on the expression of 16 autophagy‑related genes for multiple myeloma survival

Zhu¹,

Wang

Zeng³

et al. 2019

Oncol Lett

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“…XBP‐1 protein then interacts with the promoters of several genes involved in UPR and ER‐assisted degradation in order to restore protein homeostasis and promote cytoprotection . For regulation of ER stress–induced autophagy, IRE1α activates the XBP1–FOXO1 interaction and TNF receptor–associated factor 2–apoptosis signal‐regulating kinase 1/JNK cascade . XBP‐1 mRNA splicing also triggers autophagy through transcriptional activation of Beclin 1 .…”

Section: Molecular Regulation Of Autophagy Machinerymentioning

confidence: 99%

Molecular regulation of autophagy machinery by mTOR‐dependent and ‐independent pathways

Al‐Bari

2020

Annals of the New York Academy of Sciences

206

109

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Macroautophagy is a lysosomal degradative pathway or recycling process that maintains cellular homeostasis. This autophagy involves a series of sequential processing events, such as initiation; elongation and nucleation of the isolation membrane; cargo recruitment and maturation of the autophagosome (AP); transport of the AP; docking and fusion of the AP with a late endosome or lysosome; and regeneration of the lysosome by the autophagic lysosomal reformation cycle. These events are critically coordinated by the action of a set of several key components, including autophagy‐related proteins (Atg), and regulated by intricate networks, such as mechanistic target of rapamycin (mTOR), a master regulator of autophagy, as well as mTOR‐independent signaling pathways. Among mTOR‐independent pathways, the transient receptor potential (TRP) calcium ion channel TRPML (mucolipin) subfamily is emerging as an important signaling channel to modulate lysosomal biogenesis and autophagy. This review discusses the recent advances in elucidating the molecular mechanisms and regulation of the autophagy process. Understanding these mechanisms may ultimately allow scientists and clinicians to control this process in order to improve human health.

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“…It has been reported that ER stress is accompanied with autophagy that may promote cellular survival (29,50). Autophagy is a catabolic process that degrades and recycles damaged macromolecules and organelles (29,51).…”

Section: Discussionmentioning

confidence: 99%

Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy

Zheng

Liu

et al. 2018

FASEB j.

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Osteoarthritis (OA) is a disease characterized by cartilage damage and abnormal remodeling of subchondral bone. Our previous study showed that in the early stage of OA, knee loading exerts protective effects by suppressing osteoclastogenesis through Wnt signaling, but little is known about loading effects at the late OA stage. Endoplasmic reticulum (ER) stress and autophagy are known to be involved in the late OA stage. We determined the effects of mechanical loading on ER stress and autophagy in OA mice. One hundred seventy‐four mice were used for a surgery‐induced OA model. In the first set of experiments, 60 mice were devoted to evaluation of the role of ER stress and autophagy in the development of OA. In the second set, 114 mice were used to assess the effect of knee loading on OA. Histologic, cellular, microcomputed tomography, and electron microscopic analyses were performed to evaluate morphologic changes, ER stress, and autophagy. Mechanical loading increased phosphorylation of eukaryotic translation initiation factor 2α(eIF2α) and regulated expressions of autophagy markers LC3II/I and p62. Osteoarihritic mice also exhibited an elevated ratio of calcified cartilage to total articular cartilage (CC/TAC), and synovial hyperplasia with increased lining cells was found. At the early disease stage, subchondral bone plate thinning and reduced subchondral bone volume fraction (B.Ar/T.Ar) were observed. At the late disease stages, subchondral bone plate thickened concomitant with increased B.Ar/T.Ar. Mice subjected to mechanical loading exhibited resilience to cartilage destruction and a correspondingly reduced Osteoarthritis Research Society International score at 4 and 8 wk, as well as a decrease in synovitis and CC/TAC. While chondrocyte numbers in the OA group was notably decreased, mechanical loading restored chondrogenic differentiation. These results demonstrate that mechanical loading can retard the pathologic progression of OA at its early and late stages. The observed effects of loading are associated with the regulations of ER stress and autophagy.—Zheng, W., Li, X., Liu, D., Li, J., Yang, S., Gao, Z., Wang, Z., Yokota, H., Zhang, P. Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy. FASEB J. 33,4077–4088 (2019). http://www.fasebj.org

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XBP1-FoxO1 interaction regulates ER stress-induced autophagy in auditory cells

Cited by 64 publications

References 80 publications

A predicted risk score based on the expression of 16 autophagy‑related genes for multiple myeloma survival

A predicted risk score based on the expression of 16 autophagy‑related genes for multiple myeloma survival

Molecular regulation of autophagy machinery by mTOR‐dependent and ‐independent pathways

Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy

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