XCoe2, a transcription factor of the Col/Olf-1/EBF family involved in the specification of primary neurons in Xenopus

Dubois, L.; Bally‐Cuif, Laure; Crozatier, Michèle; Moreau, Jacques; Paquereau, Laurent; Víncent, Alaín

doi:10.1016/s0960-9822(98)70084-3

Cited by 124 publications

(130 citation statements)

References 42 publications

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“…In agreement, neurogenin-1 and Olf-1 binding sites are present on the minimal BM88 promoter, whereas neurogenin-1 directly transactivates the BM88 promoter (17). Neurogenins and Olf-1 act upstream of NeuroD to promote neurogenesis (31)(32)(33). Although the exact mechanism of action of BM88 is not known, an interesting speculation is the participation of BM88 in proneural gene networks for controlling neurogenesis.…”

Section: Discussionmentioning

confidence: 73%

BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors

Politis

Makri²,

Thomaidou³

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 73%

BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors

Politis

Makri²,

Thomaidou³

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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“…To confirm these results, we analyzed the temporal expression of general markers of neuronal genesis, the transcription factors Ebf2 and NeuroM, which are involved in early steps of neuronal differentiation (Garel et al, 1997;Roztocil et al, 1997;Dubois et al, 1998). Expression of ebf2 and neuroM in the ventral spinal cord was assessed around the time of OLP induction.…”

Section: Resultsmentioning

confidence: 99%

Ventral Neural Progenitors Switch toward an Oligodendroglial Fate in Response to Increased Sonic Hedgehog (Shh) Activity: Involvement of Sulfatase 1 in Modulating Shh Signaling in the Ventral Spinal Cord

Danesin

Agius²,

Escalas³

et al. 2006

J. Neurosci.

109

148

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In the embryonic chick ventral spinal cord, the initial emergence of oligodendrocytes is a relatively late event that depends on prolonged Sonic hedgehog (Shh) signaling. In this report, we show that specification of oligodendrocyte precursors (OLPs) from ventral Nkx2.2-expressing neural progenitors occurs precisely when these progenitors stop generating neurons, indicating that the mechanism of the neuronal/oligodendroglial switch is a common feature of ventral OLP specification. We further show that an experimental early increase in the concentration of Shh is sufficient to induce premature specification of OLPs at the expense of neuronal genesis indicating that the relative doses of Shh received by ventral progenitors determine whether they become neurons or glia. Accordingly, we observe that the Shh protein accumulates at the apical surface of Nkx2.2-expressing cells just before OLP specification, providing direct evidence that these cells are subjected to a higher concentration of the morphogen when they switch to an oligodendroglial fate. Finally, we show that this abrupt change in Shh distribution is most likely attributable to the timely activity of Sulfatase 1 (Sulf1), a secreted enzym that modulates the sulfation state of heparan sulfate proteoglycans. Sulf1 is expressed in the ventral neuroepithelium just before OLP specification, and we show that its experimental overexpression leads to apical concentration of Shh on neuroepithelial cells, a decisive event for the switch of ventral neural progenitors toward an oligodendroglial fate.

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“…Among these are the winged helix transcription factor XBF1 (28), the distal-less related homeobox gene XDlx5 (30), a gene related to Drosophila empty spiracles, XEmx2 (31), and the helixloop-helix factor Xebf2 (29). At the neurula stage XDlx5 and XBF1 are also detected in the anterior neural ridge (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Both gain-of-function (29,33) and loss-offunction (50-53) obtained in various model organisms have implicated Olf͞Ebf genes in key stages of neural development (43). The loss of Xebf2 expression in Dmrt4-deficient embryos correlates with reduced NCAM expression in the olfactory epithelium, suggesting that Xebf2 controls neurogenesis in the olfactory system downstream of XDmrt4.…”

Section: Discussionmentioning

confidence: 99%

The doublesex-related gene, XDmrt4 , is required for neurogenesis in the olfactory system

Huang

Hong

O’Donnell

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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The Dmrt genes encode a large family of transcription factors whose function in sexual development has been well studied. However, their expression pattern is not restricted to the gonad, suggesting that Dmrt genes might regulate other developmental processes. Here, we report the expression and functional analysis of one member of this family: Xenopus Dmrt4 (XDmrt4). XDmrt4 is initially expressed in the anterior neural ridge and then becomes progressively restricted to part of the telencephalon and the olfactory placode͞epithelium. XDmrt4 is induced at the anterior neural plate by a balance of neural inducers and caudalizing factors. Interference with XDmrt4 function by injection of a morpholino oligonucleotide or an inhibitory mutant resulted in a similar phenotype, the specific disruption of the olfactory placode expression of Xebf2 without affecting the expression of other placodal markers. Xebf2 belongs to a family of helix-loop-helix transcription factors implicated in neuronal differentiation, and later in embryogenesis XDmrt4-deficient embryos show impaired neurogenesis in the olfactory epithelium. Consistent with this finding, XDmrt4 is sufficient to activate neurogenin, Xebf2, and neural cell adhesion molecule expression in animal explants and is required for Noggin-mediated neuralization. Altogether, these results indicate that XDmrt4 is an important regulator of neurogenesis in the olfactory system upstream of neurogenin and Xebf2.placode ͉ Xenopus ͉ Xebf2 ͉ forebrain ͉ neurogenin G enes related to the Drosophila doublesex and Caenorhabditis elegans mab-3 genes encode transcription factors conserved during evolution (1). They constitute the Dmrt (doublesex and mab-3-related transcription factor) gene family, a class of molecules characterized by a signature zinc finger-like DNA-binding motif known as the DM domain (2).Dmrt genes have been shown to regulate sexual development in arthropods, nematodes, and vertebrates and, as such, represent a rare example of genes whose function in sex regulation has been highly conserved during evolution (3). Dmrt1 was the first DM domain gene identified in vertebrates (4). In the mouse, Dmrt1 is expressed in the genital ridge, and upon sexual differentiation its expression decreases in the ovary and is maintained in the testis (4). Mice with a targeted deletion of Dmrt1 show normal development in XX individuals, whereas genetically male individuals have severely hypoplastic testes (5). In humans, DMRT1 maps to the short arm of chromosome 9, and hemizygous deletion of this region is associated with defective testicular development (6, 7). Dmrt1 has also been isolated in fish (8-13), amphibians (14), reptiles (15), and marsupials (16), and Dmrt1 expression pattern in these species is consistent with a role in testis differentiation.There is accumulating evidence from different phyla that more than one Dmrt gene could be involved in sexual development. For example, Dmrt3, Dmrt5, and Dmrt7 also exhibit sexually dimorphic expression in the early embryonic gonad (17). Conv...

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XCoe2, a transcription factor of the Col/Olf-1/EBF family involved in the specification of primary neurons in Xenopus

Cited by 124 publications

References 42 publications

BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors

BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors

Ventral Neural Progenitors Switch toward an Oligodendroglial Fate in Response to Increased Sonic Hedgehog (Shh) Activity: Involvement of Sulfatase 1 in Modulating Shh Signaling in the Ventral Spinal Cord

The doublesex-related gene, XDmrt4 , is required for neurogenesis in the olfactory system

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