Xenobiotic Metabolism Genes and the Risk of Recurrent Spontaneous Abortion

Hirvonen, Ari; Taylor, Jack A.; Wilcox, Allen J.; Berkowitz, Gertrud S.; Schachter, Beth S.; Chaparro, Carlos A.; Bell, Douglas A.

doi:10.1097/00001648-199603000-00018

Cited by 20 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…not influence the susceptibility for REPL. The role of the Therefore we investigated polymorphisms in CYP1A1 which GSTM1 null genotype in association of REPL has also been can lead to a more active enzyme, in combination with studied (Hirvonen et al, 1996). However, results were controgene alterations in GST which result in (partly) deleted versial: in their so-called North Carolina study (n ϭ 29) the enzyme activity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss

Zusterzeel

Nelen²,

Roelofs³

et al. 2000

MHR: Basic Science of Reproductive Medicine

View full text Add to dashboard Cite

An imbalance between phase I drug metabolizing enzymes and phase II detoxification enzymes may contribute to the development of pre-eclampsia. Polymorphic variants in the phase I enzyme, cytochrome P450 genes may lead to increased toxification, whereas polymorphisms in the phase II enzyme, glutathione S-transferase genes may result in impaired detoxification. Most abundant in placenta and decidua is glutathione S-transferase P1-1, which may therefore be of particular importance in reproduction. We studied the frequencies of polymorphic variants in those enzymes in 187 women with recurrent early pregnancy loss and in 109 women with an uncomplicated obstetric history. DNA was extracted and subsequently polymerase chain reaction based genotyping assays were used. chi(2)-Analysis and Fisher's exact test were used for statistical evaluation. The glutathione S-transferase P1b-1b genotype was found significantly more often in women with recurrent early pregnancy loss than in controls (12% versus 5%, P = 0.03), in particular in those who consumed coffee (P = 0.02) or smoked cigarettes (P = 0.04). Polymorphisms in other glutathione S-transferase and cytochrome P450 genes occurred equally frequently in cases and controls. In conclusion, the occurrence of the glutathione S-transferase P1b-1b genotype, leading to lower glutathione S-transferase Pi enzyme activity and consequently to impaired placental detoxification, may represent a risk factor for recurrent early pregnancy loss.

show abstract

Section: Discussionmentioning

confidence: 99%

“…study. Furthermore, important lifestyle habits such as smoking In human placenta (Awasthi et al, 1994) and decidua cigarettes and consumption of alcohol or caffeine were not GSTP1-1 is by far the most abundant investigated (Hirvonen et al, 1996). GST isoenzyme.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss

Zusterzeel

Nelen²,

Roelofs³

et al. 2000

MHR: Basic Science of Reproductive Medicine

View full text Add to dashboard Cite

show abstract

“…104 In addition, a relatively higher RM risk of GSTM1 null among women with three or more pregnancy losses (OR, 2.90) was found. 104 Hirvonen et al 105 reported an association between RM and the GSTM1-null genotype in North Carolina, whereas there was an inverse association between risk of RM and the null genotype in New York. This study was composed of only 29 cases in North Carolina and 89 cases in New York.…”

Section: Hla-g Genementioning

confidence: 99%

Genetic Factors in Fetal Growth Restriction and Miscarriage

Yamada

Sata²,

Saijo³

et al. 2005

Semin Thromb Hemost

View full text Add to dashboard Cite

Recently, several investigations concerning disadvantageous genetic factors in human reproduction have progressed. Inherited thrombophilia, such as factor V Leiden, prothrombin, and methylenetetrahydrofolate reductase mutations; gene polymorphisms of detoxification enzyme (CYP1A1); growth factors (insulin-like growth factor-I); and hormones such as angiotensinogen and CYP17 are involved in the pathogenesis of fetal growth restriction. The inherited thrombophilia, gene polymorphisms of coagulation and anticoagulation factor such as thrombomodulin, endothelial protein C receptor, plasminogen activator inhibitor 1, and factor XIII; human lymphocyte antigen (HLA-G); detoxification enzymes (glutathione- S-transferase M1); cytokines such as interleukin (IL) -1 and IL-6; hormones (CYP17); vasodilators (nitric oxide synthase 3); and vitamins (transcobalamin) are involved in the pathogenesis of sporadic and recurrent miscarriage. It is likely that a gene polymorphism or mutation susceptible to reproductive failure has a beneficial effect on the process of human reproduction with or without the environmental interaction. The factor V Leiden mutation has genetic advantages that are believed to be an improved implantation rate in in vitro fertilization and a reduction of maternal intrapartum blood loss. It has also been demonstrated that the CYP17 A2 allele has bidirectional effects on human reproduction, including increases in susceptibility to recurrent miscarriage and fetal growth enhancement.

show abstract

“…Су пе реч ливі дані сто сов но асоціації генів GSTM1 і GSTT1 з не ви но шу ван ням вагітності от ри ма но у дослідженні ав торів [21], де вста нов ле но асоціацію для де леції ге на GSTM1 і в той же час відсутність асоціації для де леції ге на GSTT1. В іншій ро боті не ви яв ле но асоціації для делеції ге на GSTM1 [22]. Подібні розбіжності на водять на дум ку про не обхідність роз ши рен ня досліджу ва них і кон троль них груп, за лу че них до аналізу асоціації.…”

unclassified

Study of the possible role of polymorphisms of the detoxication and coagulation system genes in pathogenesis of pregnancy loss

Tatarskyy

Kucherenko

Khazhilenko³

et al. 2011

Biopolym. Cell

View full text Add to dashboard Cite

Aim. To study association of polymorphisms of the genes of the first CYP1A1 (T6235C) and second GSTM1 («0»), GSTT1 («0»), GSTP1 (A313G) phases of detoxication system as well as polymorphic variants of the genes of proteins of coagulation system F2 (G20210A), F5 (G1691A), and folate metabolism system MTHFR (C677T) with pathogenesis of pregnancy loss. Methods. Polymorphic variants were analyzed using PCR followed by RFLP analysis in 86 healthy individuals and in 109 patients with different types of pregnancy loss. Results. Unfavorable polymorphic variants GSTP1 (313G) and CYP1A1 (6235C) were observed more frequently in the patients with pregnancy loss comparing to the control group. Conclusions. We assume that the 313G polymorphic variant of GSTP1 gene may be considered as a factor of hereditary susceptibility to pregnancy loss

show abstract

Xenobiotic Metabolism Genes and the Risk of Recurrent Spontaneous Abortion

Cited by 20 publications

References 0 publications

Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss

Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss

Genetic Factors in Fetal Growth Restriction and Miscarriage

Study of the possible role of polymorphisms of the detoxication and coagulation system genes in pathogenesis of pregnancy loss

Contact Info

Product

Resources

About