Xenon-CT Cerebral Blood Flow Evaluation of Cerebral Ischemia in Children and Young Adults

The cerebral blood flow (CBF) of 25 patients with sickle cell cerebrovascular disease (SCCVD) was examined using a Xenon-CT flow mapping method. Brain CT and MR findings were correlated with those of the Xenon-CT flow studies. CBF defects on Xenon-CT correlated reasonably well with the areas of cortical infarctions on the MR images, but in 27% of the cases, flow defects were slightly larger than the areas of infarctions on the MR images. In deep watershed or basal ganglia infarctions, abnormal CBF was noted about the cerebral cortex near infarctions in 72% of the patients, regardless of infarction sizes on the MR images. However, decreased CBF was recognized in 4 of the 9 children whose MR images were virtually normal. Thus, the extent of flow depletion cannot be predicted accurately by MR imaging alone. Xenon-CT flow mapping proved a safe and reliable procedure for evaluation of the CBF of patients with SCCVD. Although this study is preliminary, it may have a potential in selecting patients for hypertransfusion therapy, as a noninvasive test and for following children with SCCVD during their therapy. Careful correlation of results of CBF with those of MR imaging or of CT is important for objective interpretations of flow mapping images.

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Cerebral blood flow mapping using stable Xenon-enhanced CT in sickle cell cerebrovascular disease

Numaguchi

Haller

Humbert

et al. 1990

Neuroradiology

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Neurointensive care of the nonaccidentally injured child

Stevenson

Adelson

2002

Neurosurgery Clinics of North America

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CBF Measured by Xe-CT: Approach to Analysis and Normal Values

Yonas

Darby

Marks

et al. 1991

J Cereb Blood Flow Metab

123

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Summary:Normal reference values and a practical ap proach to CBP analysis are needed for routine clinical analysis and interpretation of xenon-enhanced computed tomography (CT) CBP studies. We measured CBP in 67 normal individuals with the GE 9800 CT scanner adapted for CBP imaging with stable Xe. CBP values for vascular territories were systematically analyzed using the cluster ing of contiguous 2-cm circular regions of interest (ROls) placed within the cortical mantle and basal ganglia. Mixed cortical flows averaged 51 ± 10 ml . 100 g -1 . min -1. High and low flow compartments, sampled by placing 5-mm circular ROIs in regions containing the highest and lowest

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Xenon-CT Cerebral Blood Flow Evaluation of Cerebral Ischemia in Children and Young Adults

Cited by 5 publications

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Cerebral blood flow mapping using stable Xenon-enhanced CT in sickle cell cerebrovascular disease

Cerebral blood flow mapping using stable Xenon-enhanced CT in sickle cell cerebrovascular disease

Neurointensive care of the nonaccidentally injured child

CBF Measured by Xe-CT: Approach to Analysis and Normal Values

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