Xenon preconditioning: molecular mechanisms and biological effects

Liu, Wenwu; Liu, Ying; Chen, Han; Liu, Kan; Tao, Hengyi; Sun, Xiaobo

doi:10.1186/2045-9912-3-3

Cited by 24 publications

(15 citation statements)

References 35 publications

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“…In recent years, other medical gases such as xenon and methane are speculated to be able to act on some proteins. For example, xenon can potently inhibit the N-methyl-D-aspartate (NMDA) receptors non-competitively 33 and methane might confer an effect on membrane channels 34 . Thus, more studies are needed to elucidate the specific influence of hydrogen gas on these proteins.…”

Section: Discussionmentioning

confidence: 99%

High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway

Chen

Cao

et al. 2017

Sci Rep

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The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH). C57BL/6 mice were randomly divided into the following groups: sham, I/R, I/R + HCH, I/R + HCH + LY294002 (PI3K inhibitor), I/R + HCH + wortmannin (PI3K inhibitor), I/R + LY294002, and I/R + wortmannin. After 45 min of ischemia, HCH (67% H2 and 33% O2) was administered to mice during a 90-min reperfusion. To investigate the role of Akt1 in the protective effects of HCH, mice were divided into the following groups: I/R + A-674563 (Akt1 selective inhibitor), I/R + HCH + A-674563, I/R + CCT128930 (Akt2 selective inhibitor), and I/R + HCH + CCT128930. After a 4-h reperfusion, serum biochemistry, histological, western blotting, and immunohistochemical analyses were performed to evaluate the role of the PI3K-Akt1 pathway in the protection of HCH. In vitro, 75% hydrogen was administered to cardiomyocytes during 4 h of reoxygenation after 3-h hypoxia. Several analyses were performed to evaluate the role of the Akt1 in the protective effects of hydrogen. HCH resulted in the phosphorylation of Akt1 but not Akt2, and Akt1 inhibition markedly abolished HCH-induced cardioprotection. Our findings reveal that HCH may exert cardioprotective effects through a PI3K-Akt1-dependent mechanism.

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Section: Discussionmentioning

confidence: 99%

High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway

Chen

Cao

et al. 2017

Sci Rep

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“…The inhaled anesthetic gases can be used as either a pre-conditioning approach or a post-conditioning one. Preconditioning has demonstrated protective effects against TBI (Harris et al, 2013;Deng et al, 2014;Khan et al, 2015;Shu et al, 2016), ischemic stroke (Dingley et al, 2006;Wang et al, 2011Wang et al, , 2016Yu et al, 2011;Liu et al, 2013;Shi et al, 2013), and hemorrhagic stroke (Gigante et al, 2011;Sheng et al, 2012). Post-conditioning is a relative new concept and it has been reported in ischemic stroke (Li et al, 2014;Yin et al, 2014;Lee et al, 2015;Liu et al, 2016).…”

Section: Protective Effect Of Inhaled Anesthetic Gasesmentioning

confidence: 99%

Anti-oxidative aspect of inhaled anesthetic gases against acute brain injury

2016

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Acute brain injury is a critical and emergent condition in clinical settings, which needs to be addressed urgently. Commonly acute brain injuries include traumatic brain injury, ischemic and hemorrhagic strokes. Oxidative stress is a key contributor to the subsequent injuries and impedes the reparative process after acute brain injury; therefore, facilitating an anti-oxidative approach is important in the care of those diseases. Readiness to deliver and permeability to blood brain barrier are essential for the use of this purpose. Inhaled anesthetic gases are a group of such agents. In this article, we discuss the anti-oxidative roles of anesthetic gases against acute brain injury.

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“…Xe is a noble gas used in general anesthesia. [5] Studies have shown that xenon has protective effects on ischemia-reperfusion injury of brain . [6,7] Moreover, xenon exhibited neuroprotective activity for the treatment of ischemic brain injury in combination with mild hypothermia in animal models.…”

mentioning

confidence: 99%

The neuroprotective effects of xenon on neonatal rats with white matter damage by regulating expression of microRNA-210 and HIF-1α

Yin

Zhao

Jiang

et al. 2019

Preprint

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Background Premature birth is a significant health care burden. White matter damage (WMD) is a leading cause of acute mortality and chronic morbidity in preterm birth. Xenon(Xe) is a general anesthetic with neuroprotective effects.We aimed to reveal the molecular basis and neuroprotective mechanism of Xe intervention in treating white matter damage by detecting the expression level of microRNA 210 (miR-210) and hypoxia inducible factor 1α (HIF-1α) in brain tissues of 3-day-old neonatal rats. Methods Three-day-old SD rats were randomly divided into sham group(Group A, n=24), lipopolysaccharide(LPS)+hypoxia-ischemia(HI) group (Group B, n=24) and LPS+HI+Xe group (n=72). The onset of Xe inhalation started at 0,2 and 5 hours in subgroups C,D,and E respectively.We investigated the neurobehavioral deficits by performing TUNEL and hematoxylin and eosin (HE) staining and examining the expression of miR-210and HIF-1α in brain tissues via RT-PCR and western blot. Results HE staining revealed distorted cytoarchitecture, tangled nerve fibers and pyknosis along with apoptosis in group B.Xe treatment improved the histological alterations and decreased the number of apoptotic cells in group C pups.Compared to group A,Detection of miR-210 level by RT-PCR. the expression level of miR-210 in neonatal rats' periventricular tissue increased significantly at all time points in group B (p<0.05).While the expression level of miR-210 in brain tissues of group B was significantly lower at 48h and 72h than that of group C(p<0.05).Similarly,Detection of HIF-1α protein by Western blot. The level of HIF-1α protein in group B brain tissues was significantly higher than that of group A at each time point (p<0.05), Xe treatment resulted in a marked increase in HIF-1α in C,D, and E subgroups (P < 0.05, compared togroup B). Conclusions These results demonstrate that the expression of HIF-1α and miR-210 increased in periventricular tissues and Xe could relieve the white matter damage by up-regulating the expression of HIF-1α and its target gene miR-210.The Xe therapeutic time window was within 5 hours after intervention, the sooner the better.

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Xenon preconditioning: molecular mechanisms and biological effects

Cited by 24 publications

References 35 publications

High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway

High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway

Anti-oxidative aspect of inhaled anesthetic gases against acute brain injury

The neuroprotective effects of xenon on neonatal rats with white matter damage by regulating expression of microRNA-210 and HIF-1α

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