2019
DOI: 10.1111/xen.12538
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Xenotransplantation literature update, March/April 2019

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(1 citation statement)
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“…Transgenic piglets expressing hCD47 have revealed a significant protective effect on xenogeneic hematopoietic engraftment in an in vivo mouse model and likely contributed to the induction of chimeric xenograft tolerance in a pig‐to‐baboon xenotransplantation model 19,20 . Taken together, the regulation of the recipient macrophage response through CD47‐SIRPα signaling by the generation of hCD47‐transgenic pigs is a promising approach for improving xenograft survival 18,21,22 . Gene editing via CRISPR/Cas9 provides a very effective option to control antigen and transgenic gene expression 23 .…”
Section: Introductionmentioning
confidence: 99%
“…Transgenic piglets expressing hCD47 have revealed a significant protective effect on xenogeneic hematopoietic engraftment in an in vivo mouse model and likely contributed to the induction of chimeric xenograft tolerance in a pig‐to‐baboon xenotransplantation model 19,20 . Taken together, the regulation of the recipient macrophage response through CD47‐SIRPα signaling by the generation of hCD47‐transgenic pigs is a promising approach for improving xenograft survival 18,21,22 . Gene editing via CRISPR/Cas9 provides a very effective option to control antigen and transgenic gene expression 23 .…”
Section: Introductionmentioning
confidence: 99%