2003
DOI: 10.1258/jrsm.96.3.111
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Xenotransplantation: where are we today?

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Cited by 31 publications
(15 citation statements)
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“…The impact of feeding and breeding has been investigated and attention paid to the appearance of diseases related to intense selection, for example the halothane gene and malignant hyperthermia (MH) or porcine stress syndrome (PSS; Nelson, 2002;Depreux et al, 2002). Recently, the pig has become important in medicine, not only as a model for studying human disease, but also for the development of xenotransplantation (see, for example, Halperin, 2001;Dooldeniya and Warrens, 2003) and for the use of a small size variant (mini-pig) as a valuable pharmacological model (Bollen and Ellegaard, 1997). The amount of information on genes and…”
mentioning
confidence: 99%
“…The impact of feeding and breeding has been investigated and attention paid to the appearance of diseases related to intense selection, for example the halothane gene and malignant hyperthermia (MH) or porcine stress syndrome (PSS; Nelson, 2002;Depreux et al, 2002). Recently, the pig has become important in medicine, not only as a model for studying human disease, but also for the development of xenotransplantation (see, for example, Halperin, 2001;Dooldeniya and Warrens, 2003) and for the use of a small size variant (mini-pig) as a valuable pharmacological model (Bollen and Ellegaard, 1997). The amount of information on genes and…”
mentioning
confidence: 99%
“…In recent years considerable progress has been achieved in overcoming hyperacute rejection associated with xenotransplantation due to the generation of human complement regulatory protein transgenic pigs as well as pigs deficient in ␣1,3-galactosyltransferase (GalT) 4 (2). Unfortunately, acute vascular rejection (AVR), an Ab-mediated disease, remains the primary barrier to successful xenotransplantation (3,4). Furthermore conventional immunosuppressive drugs such as cyclosporin A (CsA), which is very effective in blocking cell-mediated rejection (CMR) in allotransplantation, have very limited effects on AVR in xenotransplantation.…”
mentioning
confidence: 99%
“…Additionally, there is also a risk of xenograft organs wearing out or failing prematurely, because pigs typically have a shorter lifespan than humans, that is, 10 -15 years. [19,20] This means that their tissues ARTICLE age at a quicker rate than human tissues. [19] Knowledge on the longevity of xenograft organs in humans is deficient.…”
Section: Wear and Tearmentioning
confidence: 99%
“…[19] Knowledge on the longevity of xenograft organs in humans is deficient. [20] However, it is important to recognise that the use of porcine organs would become more common and probably reduce the cost of organ donation, meaning that, assuming they were required, later additional surgeries would be available and affordable.…”
Section: Wear and Tearmentioning
confidence: 99%